Genus Morus

  • 桑属植物(桑科)自古以来就被用作传统的药用和可食用资源。桑属已被认为是探索具有各种生物活性的新型化合物的有希望的资源。从2011年到2023年,对该属的植物化学研究导致发现了大约453种天然产物,主要包括类黄酮,Diels-Alder加合物,2-芳基苯并呋喃,生物碱和二苯乙烯。该属的生物活性成分和提取物显示出广泛的令人印象深刻的生物学特性,包括抗糖尿病,抗炎,抗氧化剂,抗癌,保肝,保护肾脏,和其他一些活动。在这里,系统介绍了该属植物2011-2023年在植物化学和药理方面的研究进展,并进行了讨论。鉴于增强对该属研究的连续性,当前的评论为读者和研究人员提供了有关桑属属的信息的最简单访问。
    Species of genus Morus (family Moraceae) have been used as traditional medicinal and edible resources since ancient times. Genus Morus has been acknowledged as a promising resource for the exploration of novel compounds with various bioactivities. Phytochemical investigations of the genus have led to the discovery of more than approximately 453 natural products from 2011 to 2023, mainly including flavonoids, Diels-Alder adducts, 2-arylbenzfuran, alkaloids and stilbenes. Bioactive constituents and extracts of this genus displayed a wide range of impressive biological properties including antidiabetic, anti-inflammatory, antioxidant, anti-cancer, hepatoprotective, renoprotective, and some other activities. Herein, the research progress of this genus Morus from 2011 to 2023 on phytochemistry and pharmacology are systematically presented and discussed for the first time. This current review provides the easiest access to the information on genus Morus for readers and researchers in view of enhancing the continuity on research done on this genus.
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  • 文章类型: Journal Article
    酪氨酸酶是一种多功能的,含铜和限速氧化酶,催化黑色素生成途径中的关键步骤,并负责哺乳动物的皮肤色素沉着异常。衍生自天然和合成来源的许多酪氨酸酶抑制剂已被确定为开发抗黑素生成剂的目标。然而,由于副作用和缺乏预期的效率,其中只有一小部分用于医疗和美容目的。这篇重要的综述集中在寻找新的活性物质和最近发现的来自桑属(桑科)的植物来源的抗酪氨酸酶抑制剂。讨论了它们的结构-活性关系的详细分析。本文中包含的信息对化妆品和医疗行业至关重要,为有效寻找天然抗黑色素生成产品(具有令人满意的效率和安全性)治疗和治愈色素沉着的新方向。
    Tyrosinase is a multifunctional, copper-containing and rate-limiting oxidase that catalyses crucial steps in the melanogenesis pathway and is responsible for skin-pigmentation abnormalities in mammals. Numerous tyrosinase inhibitors derived from natural and synthetic sources have been identified as an objective for the development of anti-melanogenesis agents. However, due to side effects and lack of expected efficiency, only a small percentage of them are used for medical and cosmetic purposes. This critical review focuses on searching for novel active substances and recently discovered plant-derived anti-tyrosinase inhibitors from the Morus genus (Moraceae family). A detailed analysis of their structure-activity relationships is discussed. The information contained in this article is crucial for the cosmetics and medical industries, in order to show new directions for the effective search for natural anti-melanogenesis products (with satisfactory efficiency and safety) to treat and cure hyperpigmentation.
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