General Medicine

普通医学
  • 文章类型: Journal Article
    在美国,药学博士(PharmD)计划需要在医院/卫生系统药房和住院普通医学患者护理的核心住院轮换领域提供先进的药学实践经验(APPE)。全国范围内的学院和制药学院(C/SOP)越来越多地利用混合或纵向APPE模型来提供体验机会;但是,当将两个或多个轮换整合在一起时,文献中在支持计划与描述轮换特定能力方面存在差距。利用测量仪器,两个C/SOP的PharmD学生报告了他们在医院/健康药房系统的四个能力领域内实现的现场住院轮换子能力活动,用药安全与质量,临床应用,专业实践,在2016年药学教育标准认证委员会指导文件附录C中列出。进行了不成对的两样本t检验,以比较两个轮换设置中的亚能力活动发生的比例。总的来说,168名学生报告了与四个能力领域相关的住院活动,95-100%的人报告他们参与了每个领域的一个或多个子能力机会。在比较的26个子能力中,对于一种APPE住院患者轮换类型,与另一种患者相比,73%显着促进了能力的发展(p<0.05)。当混合住院经验机会时,C/SOP可以利用这些发现来支持轮换特定能力的描述。
    In the United States, Doctor of Pharmacy (PharmD) programs are required to provide advanced pharmacy practice experiences (APPEs) in the core inpatient rotation areas of hospital/health system pharmacy and inpatient general medicine patient care. Colleges and Schools of Pharmacy (C/SOPs) nationwide are increasingly utilizing blended or longitudinal APPE models to offer experiential opportunities; however, there is a gap in the literature to support programs with delineating rotation-specific competencies when integrating two or more rotations together. Utilizing a survey instrument, PharmD students at two C/SOPs reported their onsite inpatient rotation sub-competency activities achieved within the four competency areas of Hospital/Health Pharmacy Systems, Medication Safety and Quality, Clinical Applications, and Professional Practice, which are listed in Appendix C of the 2016 Accreditation Council for Pharmacy Education Standards Guidance Document. Unpaired two-sample t-tests were performed to compare proportions of sub-competency activity occurrence in the two rotation settings. In total, 168 students reported inpatient activities related to the four competency areas, with 95-100% reporting their involvement in one or more sub-competency opportunities within each area. Of the 26 sub-competencies compared, 73% significantly facilitated the development of competency to a greater extent for one APPE inpatient rotation type over the other (p < 0.05). The findings can be utilized by C/SOPs to support the delineation of rotation-specific competencies when blending inpatient experiential opportunities.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    介绍高白蛋白血症,定义为血清白蛋白水平升高,可能会影响医疗保健利用率,特别是计划外的医疗访问。交感神经系统(SNS)调节血清白蛋白,这对于维持致癌压力和物质运输至关重要。SNS不稳定,与慢性病有关,会影响白蛋白水平。这项研究调查了高白蛋白血症与社区医院门诊部计划外就诊之间的关系,旨在确立其作为医疗保健利用预测指标的潜力。方法本回顾性队列研究利用Unnan市医院的电子病历,Japan,从2021年9月到2023年8月。参与者年龄超过15岁,有白蛋白数据,不包括患有急性白蛋白疾病的患者。病例组包括321例高白蛋白血症患者(血清白蛋白≥5g/dL),每月与16个对照相匹配。人口统计数据,慢性疾病,并收集了计划外的医疗访问。多因素logistic回归分析了高白蛋白血症与计划外就诊的相关性。结果在716名参与者中,高白蛋白血症组(平均年龄59.13岁)比非高白蛋白血症组(平均年龄74.36岁)年轻.高白蛋白血症患者的BMI较高,脉搏率,和糖尿病的患病率,血脂异常,和脑中风。发现高白蛋白血症和计划外就诊之间存在显著关联(OR2.35,95%CI1.56-3.53,p<0.001),年龄,BMI,脉搏率,和脑中风。结论高白蛋白血症与农村门诊病人计划外就诊次数增加显著相关。常规血清白蛋白评估有助于风险分层和个性化护理,有可能减少急性医疗需求。未来的研究应该探索潜在的机制和更广泛的人群,以加强临床应用。
    Introduction Hyperalbuminemia, defined as elevated serum albumin levels, may influence healthcare utilization, particularly unscheduled medical visits. The sympathetic nervous system (SNS) regulates serum albumin, which is crucial for maintaining oncotic pressure and substance transport. SNS instability, linked to chronic diseases, can impact albumin levels. This study investigates the association between hyperalbuminemia and unscheduled medical visits in community hospital outpatient departments, aiming to establish its potential as a predictor of healthcare utilization. Methods This retrospective cohort study utilized electronic medical records from Unnan City Hospital, Japan, from September 2021 to August 2023. Participants were over 15 years old and had albumin data available, excluding those with acute albumin conditions. The case group consisted of 321 hyperalbuminemia patients (serum albumin ≥ 5 g/dL), matched monthly with 16 controls. Data on demographics, chronic diseases, and unscheduled medical visits were collected. Multivariate logistic regression analyzed the association between hyperalbuminemia and unscheduled medical visits. Results Among 716 participants, the hyperalbuminemia group (mean age 59.13 years) was younger than the non-hyperalbuminemia group (mean age 74.36 years). Hyperalbuminemia patients had a higher BMI, pulse rate, and prevalence of diabetes, dyslipidemia, and brain stroke. Significant associations were found between hyperalbuminemia and unscheduled medical visits (OR 2.35, 95% CI 1.56-3.53, p < 0.001), age, BMI, pulse rate, and brain stroke. Conclusion Hyperalbuminemia is significantly associated with increased unscheduled medical visits in rural outpatient settings. Routine serum albumin assessments can aid in risk stratification and personalized care, potentially reducing acute healthcare needs. Future research should explore underlying mechanisms and broader populations to enhance clinical applications.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    目的:1.为了探索医生的看法,注册护士(RN)和专职医疗专业人员(AHP)对基于病房的高级实践护士(APN)的作用。2.检查医疗保健专业人员对APN在住院护理中角色扩展的看法。
    方法:横断面研究。
    方法:从2022年11月至2023年2月,在三级医院的五个医疗病房中,对医疗保健专业人员对基于病房的APN的看法进行了包括五个领域的43项调查。参与者是通过电子邮件和跨平台消息传递服务使用便利抽样招募的。
    结果:共有181名完成的受访者,包括26名医生,102名护士和45名AHP。用IBMSPSS版本28.0进行统计分析。人们认为APN在所有五个领域都花费了大量的时间,即,“直接全面护理”,\'系统支持\',\'研究\',\'教育\'和\'出版和专业领导\'。根据APN的先前经验以及不同的医疗保健专业之间的看法存在显着差异。大多数人认识到APN对患者安全的积极影响,效率和以患者为中心。
    结论:这项研究为基于病房的APN实践模式提供了有价值的见解,角色和影响,揭示了他们在住院普通病房中接受和扩大角色的积极转变。它还强调了基于病房的APN在直接患者护理中的重要作用和影响,系统支持,研究,教育和领导,尽管角色清晰度方面存在挑战,特别是在治疗计划和查房方面。
    APNs在病房中被认为是称职且始终如一的人员。然而,关于APNs开展的临床活动存在分歧。
    研究解决了什么问题?○基于病房的APN的角色歧义。○医疗保健专业人员对APN的准备和接受。主要发现是什么?○APN被认为对直接患者护理有很大的参与,系统的支持,研究,教育和领导。○APN因其对患者安全的重大影响而得到认可,效率和以病人为中心,但是对他们在不同实践领域花费的时间有不同的看法。○强调了APN参与每日病房和启动出院计划的关键作用,强调它们在护理的及时性和连续性方面的重要性。研究将在何处以及对谁产生影响?○它将影响包括医生在内的医疗保健专业人员,护士,通过提供对病房APN的作用和贡献的见解,专职医疗专业人员和医疗保健管理员。○调查结果将指导政策制定者和护士领导者做出关于APN角色的实施和发展的知情决定,最终改善患者护理和结果。
    没有患者或公共捐款。
    OBJECTIVE: 1. To explore the perceptions of physicians, registered nurses (RN) and allied health professionals (AHP) towards the role of ward-based advanced practice nurse (APN). 2. To examine healthcare professionals\' perception of APN role expansion in inpatient care.
    METHODS: Cross-sectional study.
    METHODS: A 43-item survey comprising of five domains was conducted on healthcare professionals\' perceptions towards ward-based APNs in five medical wards of a tertiary hospital from November 2022 to February 2023. The participants were recruited using convenience sampling via email and cross-platform messaging service.
    RESULTS: A total of 181 completed respondents including 26 physicians, 102 nurses and 45 AHPs. Statistical analysis was performed with IBM SPSS Version 28.0. APNs were perceived to be spending a great extent of time across all five domains, namely, \'direct comprehensive care\', \'support of systems\', \'research\', \'education\' and \'publication and professional leadership\'. Significant differences were noted in perceptions based on prior experience with APNs and between different healthcare professions. The majority recognized APNs\' positive impact on patient safety, efficiency and patient-centeredness.
    CONCLUSIONS: This study offers valuable insights into ward-based APNs\' practice patterns, roles and impact, revealing a positive shift in their acceptance and expanding roles within inpatient general wards. It also highlights the valuable roles and impact of ward-based APNs in direct patient care, system support, research, education and leadership, despite ongoing challenges in role clarity, particularly in treatment planning and ward rounds.
    UNASSIGNED: APNs are highly regarded as competent and a consistent personnel in the wards. However, there are divided views on clinical activities that APNs undertake.
    UNASSIGNED: What problem did the study address? ○ Role ambiguity for ward-based APNs. ○ Healthcare professionals\' readiness and acceptance of APNs. What were the main findings? ○ APNs are perceived to have a strong involvement in direct patient care, support of system, research, education and leadership. ○ APNs are recognized for their significant impact on patient safety, efficiency and patient-centredness, but there were varied perceptions on the extent of time they spend in different practice domains. ○ The critical roles of APNs participating in daily ward rounds and initiating discharge plans were highlighted, emphasizing their importance in timeliness and continuity of care. Where and on whom will the research have an impact? ○ It will affect healthcare professionals including physicians, nurses, allied health professionals and healthcare administrators by providing insights into the roles and contributions of ward-based APNs. ○ The findings will guide policymakers and nurse leaders in making informed decisions about the implementation and development of APN roles, ultimately improving patient care and outcomes.
    UNASSIGNED: No Patient or Public Contribution.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    简介在农村医疗环境中,小组会议对于有效的病人护理至关重要,特别是考虑到资源和人员有限的挑战。这些会议促进了有关患者管理的协作讨论,并作为重要的教育会议。本研究探讨了农村医院家庭医学部团队会议的动态和功效,以优化患者护理和教育成果。方法本定性研究采用Unnan市医院的人种学,Unnan,日本。数据收集包括半结构化访谈,直接观察,反射场注释,和医学生的非正式对话,初级居民,和普通医学学员。重点是会议互动,教育内容,和运营挑战。数据分析涉及编码和主题化,研究人员和参与者之间正在进行的讨论,以完善研究结果。结果出现了三个关键主题。首先,患者的预后缺乏专业意识。第二,相互理解和个人自主性提高了团队素质。第三,团队医疗质量通过多样化和包容性的学习经验提高。有效促进,结构化时间管理,将实践床边学习与理论讨论相结合对于优化团队会议至关重要。心理安全,尊重个体差异,保持动机对于富有成效的团队互动至关重要。结论该研究强调了有效促进的重要性,时间管理,结合实践和理论学习,加强农村医疗机构团队会议。心理安全和相互尊重对于培养协作和积极的团队环境至关重要。解决这些因素可以改善患者护理和教育体验。未来的研究应包括不同的设置和定量措施,以验证和完善这些见解,加强农村医疗环境中的团队会议。
    Introduction In rural medical settings, team conferences are essential for effective patient care, especially given the challenges of limited resources and personnel. These conferences promote collaborative discussions on patient management and serve as vital educational sessions. This study explores the dynamics and efficacy of team conferences in the family medicine department of a rural hospital to optimize patient care and educational outcomes. Methods This qualitative study used autoethnography at Unnan City Hospital, Unnan, Japan. Data collection included semi-structured interviews, direct observation, reflective field notes, and informal conversations with medical students, junior residents, and general medicine trainees. The focus was on conference interactions, educational content, and operational challenges. Data analysis involved coding and theming, with ongoing discussions among researchers and participants to refine findings. Results Three key themes emerged. First, patient outcomes suffered from a lack of professional awareness. Second, mutual understanding and individual autonomy enhanced team quality. Third, team healthcare quality improved through diverse and inclusive learning experiences. Effective facilitation, structured time management, and integrating practical bedside learning with theoretical discussions were crucial for optimizing team conferences. Psychological safety, respect for individual differences, and maintaining motivation were essential for productive team interactions. Conclusion The study highlights the importance of effective facilitation, time management, and integrating practical and theoretical learning in enhancing team conferences in rural medical settings. Psychological safety and mutual respect are vital for fostering a collaborative and motivated team environment. Addressing these factors can improve patient care and educational experiences. Future research should include diverse settings and quantitative measures to validate and refine these insights, enhancing team conferences in rural healthcare environments.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Case Reports
    高阴离子间隙代谢性酸中毒(HAGMA)的一种少见且经常被忽视的原因是:这个案例突出了系统地接近HAGMA的重要性,当存在破坏γ-谷氨酰循环的药物如氟氯西林和对乙酰氨基酚时,将PGA作为鉴别诊断。
    Pyroglutamic acidosis (PGA) or 5-Oxoprolinuria is an uncommon and often overlooked cause of high anion gap metabolic acidosis (HAGMA). This case highlights the importance of systematically approaching HAGMA, and to consider PGA as a differential diagnosis when medications that disrupt the γ-glutamyl cycle such as flucloxacillin and paracetamol are present.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Case Reports
    纤维肌痛(FM)由于其复杂的症状和缺乏明确的测试而提出了诊断挑战。这项研究讨论了一名54岁的女性,最初被诊断为FM,以广泛的疼痛为特征,疲劳,和招标点。尽管治疗,两年后,她出现了C反应蛋白(CRP)升高和贫血,导致进一步的调查。这些测试揭示了非分泌性多发性骨髓瘤,强调对FM患者进行警惕监测的重要性。这种情况突出了需要定期进行CRP测量和彻底的随访以检测潜在的状况。早期发现和适当的干预对于管理FM和改善患者预后至关重要。
    Fibromyalgia (FM) presents a diagnostic challenge due to its complex symptoms and lack of definitive tests. This study discusses a 54-year-old female initially diagnosed with FM, characterized by widespread pain, fatigue, and tender points. Despite treatment, she developed elevated C-reactive protein (CRP) and anemia after two years, leading to further investigations. These tests revealed non-secretory multiple myeloma, underscoring the importance of vigilant monitoring in FM patients. This case highlights the need for regular CRP measurements and thorough follow-up to detect underlying conditions. Early detection and appropriate intervention are crucial in managing FM and improving patient outcomes.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    近年来,日本对通才的兴趣与日俱增。然而,由于“通才”一词的多样化使用,这些医生的具体角色仍然模棱两可。因此,研究通才的目标人群不清楚,这使得在通才实践框架内进行研究具有挑战性。因此,进行了文献检索,以研究如何在全球范围内对通才进行定义和分类。
    我们进行了一次文献检索,专门关注用英语写的文章,并使用了与通才相关的关键词,普通医学(GM),初级保健,家庭医学。根据结果,在通用汽车工作的6名医生回顾了研究结果,并讨论了发现的问题及其潜在的解决方案.
    针对GM的研究中通才的定义,家庭医学,以及在世界各地进行的初级保健,包括日本,各不相同。即使在日本的大学医院中,通才也扮演着不同的角色。没有研究根据特定的医疗实践或角色对通才进行精确的分类或定义。除了住院医生,他们主要参与美国的住院管理。
    根据文献检索结果,GM的定义不明确,背景缺乏统一性使得目标人群不清楚。因此,在医疗系统因国家或地区而异的医疗保健环境中,来自针对通才的研究的证据不能轻易应用于实际实践。通过基于临床实践的明确定义来澄清通才,将为通才研究提供更精确的目标人群,并能够积累与明确定义的通才群体相关的证据,为通用汽车的发展做出贡献。因此,未来的研究需要开发新的指标来精确分类和定义通才。
    UNASSIGNED: There has been growing interest in generalists in Japan in recent years. However, due to the diverse use of the term \"generalist\", the specific roles of these physicians remain ambiguous. Consequently, the target population for research on generalists is unclear, making it challenging to conduct studies within the generalist practice framework. Therefore, a literature search was conducted to examine how generalists are defined and classified in research worldwide.
    UNASSIGNED: We conducted a literature search that focused exclusively on articles written in English and used keywords related to generalists, general medicine (GM), primary care, and family medicine. Based on the results, six physicians working in GM reviewed the findings and discussed the identified issues and their potential solutions.
    UNASSIGNED: The definition of generalists in studies targeting GM, family medicine, and primary care conducted worldwide, including Japan, varies. Generalists exhibit diverse roles even within university hospitals in Japan. No studies provide a precise categorization or definition of generalists based on specific medical practices or roles, except for hospitalists, who are primarily involved in inpatient management in the United States.
    UNASSIGNED: The definition of GM was unclear based on the results of the literature search, and the lack of uniformity in backgrounds has rendered the target population unclear. Consequently, in healthcare settings where medical systems vary by country or region, evidence from studies targeting generalists cannot readily apply to actual practice. Clarifying generalists through an explicit definition based on clinical practice will allow for a more precise target population for research on generalists and enable the accumulation of evidence related to well-defined groups of generalists, contributing to the advancement of GM. Therefore, future research is required to develop new indicators to precisely classify and define generalists.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    女医生人数的增加与她们在学术职位和专业协会中的代表性不足形成鲜明对比。本研究旨在根据社会成员资格评估日本医院综合医学学会(JHGM)中女医生的地位,董事会成员,和年度会议作者身份。
    进行横截面分析。关于女医生的信息,社会和董事会成员,收集了年会作者身份。来自日本初级保健协会(JPCA)的数据作为对照。在JHGM和JPCA年会中接受摘要的作者的性别由姓名或互联网搜索确定。
    在JHGM中,14.2%的成员是女医生,与JPCA中的19.1%(p<0.001)相比。21名JHGM董事会成员中没有一名是女性,与JPCA中的20.5%相比(p<0.001)。JHGM董事会成员的平均经验年数明显高于JPCA董事会成员(37.0vs.28.1年,p<0.001)。2022-2023年JHGM会议的女性第一作者占17.9%,显著低于2023年JPCA会议的28.4%(p=0.002)。女性最后一位作者也看到了类似的模式(JHGM中的6.0%与JPCA中的18.8%,p<0.001)和女性主席(JHGM中的17.9%与JPCA中的40.3%,p=0.036)。
    JHGM在社会和董事会成员中的女性代表性较低,和年度会议作者身份。需要采取战略,通过增加妇女在JHGM中的参与和领导来增强多样性和包容性。
    UNASSIGNED: The increasing number of women physicians is in contrast to their underrepresentation in academic positions and professional associations. This study aimed to evaluate the status of women physicians in the Japanese Society of Hospital General Medicine (JHGM) based on society membership, board membership, and annual meeting authorship.
    UNASSIGNED: A cross-sectional analysis was conducted. Information on women physicians, society and board membership, and annual meeting authorship was collected. Data from the Japanese Primary Care Association (JPCA) served as the control. The gender of authors with accepted abstracts in the JHGM and JPCA annual meetings was determined by name or Internet search.
    UNASSIGNED: In the JHGM, 14.2% of members were women physicians, compared to 19.1% in the JPCA (p < 0.001). None of the 21 JHGM board members were women, compared to 20.5% in the JPCA (p < 0.001). The average number of years of experience was significantly higher for the JHGM board members than for the JPCA board members (37.0 vs. 28.1 years, p < 0.001). Women first authors in the 2022-2023 JHGM meeting comprised 17.9%, significantly lower than the 28.4% in the 2023 JPCA meeting (p = 0.002). Similar patterns were seen for women last authors (6.0% in the JHGM vs. 18.8% in the JPCA, p < 0.001) and women chairpersons (17.9% in the JHGM vs. 40.3% in the JPCA, p = 0.036).
    UNASSIGNED: The JHGM has low women representation in society and board membership, and annual meeting authorship. Strategies are needed to enhance diversity and inclusion by increasing women\'s participation and leadership in the JHGM.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Case Reports
    一名50岁的男子出现发烧和全身皮疹,患有慢性疲劳和淋巴结病一年半。初步测试排除了淋巴增生性疾病,显示反应性增生和巨细胞病毒。氨苄青霉素治疗后症状恶化,导致疑似药物诱发的超敏反应综合征(DIHS)。一被录取,停用了阿莫西林,启动泼尼松龙和抗病毒治疗。这种疗法使病人的病情得到改善。药物诱导的淋巴细胞刺激试验证实了对氨苄青霉素和别嘌呤醇的超敏反应。由于罕见的表现,该病例说明了慢性和急性DIHS的诊断挑战。它强调了对慢性淋巴结病和疲劳患者高度怀疑DIHS的必要性,特别是最近的药物暴露。有效的管理包括识别症状,撤回令人反感的药物,使用皮质类固醇。巨细胞病毒等病毒感染会使DIHS诊断和治疗复杂化,需要采取全面的方法。这个案例强调了在鉴别诊断中考虑DIHS的重要性,以及在农村医疗机构中与共感染一起管理DIHS的复杂性。
    A 50-year-old man presented with fever and a generalized rash, with chronic fatigue and lymphadenopathy for a year and a half. Initial tests ruled out lymphoproliferative disorders, showing reactive hyperplasia and cytomegalovirus. Symptoms worsened after ampicillin treatment, leading to suspected drug-induced hypersensitivity syndrome (DIHS). Upon admission, amoxicillin was discontinued, and prednisolone and antiviral treatment were initiated. The patient\'s condition improved with this therapy. A drug-induced lymphocyte stimulation test confirmed hypersensitivity to both ampicillin and allopurinol. This case illustrates the diagnostic challenge of chronic and acute DIHS because of the rare presentation. It underscores the need for high suspicion of DIHS in patients with chronic lymphadenopathy and fatigue, particularly with recent drug exposure. Effective management involves recognizing symptoms, withdrawing the offending drug, and using corticosteroids. Viral infections like cytomegalovirus can complicate DIHS diagnosis and treatment, necessitating a comprehensive approach. This case highlights the importance of considering DIHS in differential diagnoses and the complexities of managing it alongside co-infections in rural healthcare settings.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Case Reports
    本病例报告讨论了一名具有复杂病史的68岁男性患者抗中性粒细胞胞浆抗体(ANCA)阴性快速进展性肾小球肾炎(RPGN)的治疗。呈现疲劳,水肿,和急性肾衰竭.尽管没有特定RPGN类型的阳性生物标志物,临床进展提示显微镜下多血管炎,导致环磷酰胺和利妥昔单抗的强化免疫抑制治疗。患者的病情因肾病综合征和肾病综合征的共存而进一步复杂化,需要细致入微的管理策略,包括长时间的血液透析.最初治疗失败后,最终实现了缓解,允许停止透析和肾功能的显着恢复。此案例凸显了诊断和管理ANCA阴性RPGN的挑战,特别是量身定做的重要性,资源有限环境下的动态治疗方法。观察到的恢复强调了肾功能改善的潜力,即使经过长时间的强化治疗,加强管理复杂RPGN病例对持久性和适应性的需求。
    This case report discusses the management of anti-neutrophil cytoplasmic antibodies (ANCA)-negative rapid progressive glomerulonephritis (RPGN) in a 68-year-old man with a complex medical history, presenting with fatigue, edema, and acute renal failure. Despite the absence of positive biomarkers for specific RPGN types, the clinical progression suggested microscopic polyangiitis, leading to intensive immunosuppressive therapy with cyclophosphamide and rituximab. The patient\'s condition was further complicated by the coexistence of nephritic and nephrotic syndromes, requiring nuanced management strategies, including prolonged hemodialysis. After initial treatment failure, remission was eventually achieved, allowing cessation of dialysis and significant recovery of renal function. This case highlights the challenges of diagnosing and managing ANCA-negative RPGN, particularly the importance of a tailored, dynamic approach to treatment in resource-limited settings. The recovery observed underscores the potential for renal function improvement even after prolonged periods of intensive therapy, reinforcing the need for persistence and adaptability in managing complex RPGN cases.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

公众号