■对于坏死性软组织感染(NSTI)患者的结果报告存在不一致。这项研究的目的是评估NSTI文献中报告的结局指标,这些指标可以告知核心结局集(COS),例如可用于该适应症的高压氧研究。
■对Cochrane确定的所有NSTI文献进行系统回顾,OvidMEDLINE和Scopus数据库以及符合纳入标准并在2010年至2020年之间发布的灰色文献来源OpenGrey和纽约医学院数据库。如果研究报告了>5例病例并提供了临床终点,患者相关结果,或NSTI患者的资源利用。研究不需要包括干预。然后,两名独立研究人员提取了报告的结果指标。将类似的结果分组并分类到域中,以生成结构化清单。尝试通过研究设计来确定结果测量随时间的趋势。
■确定了三百七十五项研究,共包括311项结局指标。通过两项或更多的研究报告了48%(150/311)的结果指标。四个最常报告的结果指标是没有指定时间的死亡率,住院时间,进行截肢,清创术的数量,在298年报告(79.5%),260(69.3%),研究分别为156项(41.6%)和151项(40.3%)。死亡率结果以23种不同的方式报告。随机对照试验(RCTs)更有可能报告28天死亡率或90天死亡率。第二个最常见的截肢相关结果是截肢水平,在7.5%(28/375)的研究中报告。最常报告的以患者为中心的结果是SF-36,其在所有研究的1.6%(6/375)和2/10RCT中报告。
■在NSTI研究中,结局指标存在很大差异,进一步强调了COS的必要性。
UNASSIGNED: There are inconsistencies in outcome reporting for patients with necrotising soft tissue infections (NSTI). The aim of this study was to evaluate reported outcome measures in NSTI literature that could inform a core outcome set (COS) such as could be used in a study of hyperbaric oxygen in this indication.
UNASSIGNED: A systematic review of all NSTI literature identified from Cochrane, Ovid MEDLINE and Scopus databases as well as grey literature sources OpenGrey and the New York Academy of Medicine databases which met inclusion criteria and were published between 2010 and 2020 was performed. Studies were included if they reported on > 5 cases and presented clinical endpoints, patient related outcomes, or resource utilisation in NSTI patients. Studies did not have to include intervention. Two independent researchers then extracted reported outcome measures. Similar outcomes were grouped and classified into domains to produce a structured inventory. An attempt was made to identify trends in outcome measures over time and by study design.
UNASSIGNED: Three hundred and seventy-five studies were identified and included a total of 311 outcome measures. Forty eight percent (150/311) of outcome measures were reported by two or more studies. The four most frequently reported outcome measures were mortality without time specified, length of hospital stay, amputation performed, and number of debridements, reported in 298 (79.5%), 260 (69.3%), 156 (41.6%) and 151 (40.3%) studies respectively. Mortality outcomes were reported in 23 different ways. Randomised controlled trials (RCTs) were more likely to report 28-day mortality or 90-day mortality. The second most frequent amputation related outcome was level of amputation, reported in 7.5% (28/375) of studies. The most commonly reported patient-centred outcome was the SF-36 which was reported in 1.6% (6/375) of all studies and in 2/10 RCTs.
UNASSIGNED: There was wide variance in outcome measures in NSTI studies, further highlighting the need for a COS.