短链和中链氯化石蜡(短链氯化石蜡和中链氯化石蜡)因具有持久性和潜在毒性而受到极大关注,并且可以进行长途运输。在大小分级的颗粒相和气相中吸入的氯化链烷烃(CP)可能对人类健康带来不同的风险,因为它们能够在呼吸道的不同区域中积累并表现出不同的沉积效率。在我们的研究中,大体积的环境空气样品在两个大小分级的颗粒相(Dp<1.0μm,1.0-2.5μm,2.5-10μm,并且Dp≥10μm)和气相在北京使用主动采样器同时采集。短链氯化石蜡和中链氯化石蜡的总体水平相对较高,范围分别为57-881和30-385纳克/立方米。短链氯化石蜡倾向于在气相中分配(平均为ΣSCCP浓度的75%),而MCCP倾向于在颗粒相中分配(平均62%的ΣMCCP浓度)。在对数转换的气体-颗粒分配系数(KP)和预测的过冷蒸气压(PL0)之间(短链氯化石蜡和MCCP的p<0.01)以及对数转换的KP值与辛醇-空气分配系数(KOA)(短链氯化石蜡和MCCP的p<0.01)之间发现了显着的相关性。因此,斜率表明,有机物吸收是气体-颗粒分配的主要过程。我们使用ICRP模型来计算头部气道区域中颗粒相关CPs的沉积浓度(15.6-71.4ng/m3),气管支气管区域(0.8-4.8ng/m²),和肺泡区域(5.1-21.9纳克/立方米),然后将这些浓度与气相中的CP浓度相结合,以计算吸入的估计每日摄入量(EDI)。所有年龄组通过吸入环境空气的短链氯化石蜡和中链氯化石蜡的EDI为67.5-184.2ng/kg/天和19.7-53.7ng/kg/天,分别。结果表明,环境空气中的短链氯化石蜡和中链氯化石蜡目前对研究区域的人类健康没有很大的风险。
Short-chain and medium-chain chlorinated paraffins (SCCPs and MCCPs) have garnered significant attention because they have persistence and potential toxicity, and can undergo long-distance transport. Chlorinated paraffins (CPs) inhaled in the size-fractionated particulate phase and gas phase can carry different risks to human health due to their ability to accumulate in different regions of the respiratory tract and exhibit varying deposition efficiencies. In our study, large-volume ambient air samples in both the size-fractionated particulate phase (Dp < 1.0 μm, 1.0-2.5 μm, 2.5-10 μm, and Dp ≥ 10 μm) and gas phase were collected simultaneously in Beijing using an active sampler. The overall levels of SCCPs and MCCPs were relatively high, the ranges being 57-881 and 30-385 ng/m3, respectively. SCCPs tended to be partitioned in the gas phase (on average 75% of the ΣSCCP concentration), while MCCPs tended to be partitioned in the particulate phase (on average 62% of the ΣMCCP concentration). Significant correlations were discovered between the logarithm-transformed gas-particle partition coefficients (KP) and predicted subcooled vapor pressures (PL0) (p < 0.01 for SCCPs and MCCPs) and between the logarithm-transformed KP values and octanol-air partition coefficients (KOA) (p < 0.01 for SCCPs and MCCPs). Thus, the slopes indicated that organic matter absorption was the dominant process involved in gas-particle partitioning. We used the ICRP model to calculate deposition concentrations for particulate-associated CPs in head airways region (15.6-71.4 ng/m³), tracheobronchial region (0.8-4.8 ng/m³), and alveolar region (5.1-21.9 ng/m³), then combined these concentrations with the CP concentrations in the gas phase to calculate estimated daily intakes (EDIs) for inhalation. The EDIs for SCCPs and MCCPs through inhalation of ambient air for the all-ages group were 67.5-184.2 ng/kg/day and 19.7-53.7 ng/kg/day, respectively. The results indicated that SCCPs and MCCPs in ambient air do not currently pose strong risks to human health in the study area.