The Arctic region forms a unique environment with specific physical, chemical, and biological processes affecting mercury (Hg) cycles and limited anthropogenic Hg sources. However, historic global emissions and long range atmospheric transport has led to elevated Hg in Arctic wildlife and waterways. Continuous atmospheric Hg measurements, spanning 20 years, and increased monitoring sites has allowed a more comprehensive understanding of how Arctic atmospheric mercury is changing over time. Time-series trend analysis of TGM (Total Gaseous Mercury) in air was performed from 10 circumpolar air monitoring stations, comprising of high-Arctic, and sub-Arctic sites. GOM (gaseous oxidised mercury) and PHg (particulate bound mercury) measurements were also available at 2 high-Arctic sites. Seasonal mean TGM for sub-Arctic sites were lowest during fall ranging from 1.1 ng m-3 Hyytiälä to 1.3 ng m-3, Little Fox Lake. Mean TGM concentrations at high-Arctic sites showed the greatest variability, with highest daily means in spring ranging between 4.2 ng m-3 at Amderma and 2.4 ng m-3 at Zeppelin, largely driven by local chemistry. Annual TGM trend analysis was negative for 8 of the 10 sites. High-Arctic seasonal TGM trends saw smallest decline during summer. Fall trends ranged from -0.8% to -2.6% yr-1. Across the sub-Arctic sites spring showed the largest significant decreases, ranging between -7.7% to -0.36% yr-1, while fall generally had no significant trends. High-Arctic speciation of GOM and PHg at Alert and Zeppelin showed that the timing and composition of atmospheric mercury deposition events are shifting. Alert GOM trends are increasing throughout the year, while PHg trends decreased or not significant. Zeppelin saw the opposite, moving towards increasing PHg and decreasing GOM. Atmospheric mercury trends over the last 20 years indicate that Hg concentrations are decreasing across the Arctic, though not uniformly. This is potentially driven by environmental change, such as plant productivity and sea ice dynamics.

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a hereditary cerebral small vessel disease caused by mutations in NOTCH3, is characterized by recurrent stroke without vascular risk factors, mood disturbances, and dementia. MRI imaging shows cerebral white matter (WM) hyperintensity, particularly in the external capsule and temporal pole. Missense mutations related to a cysteine residue in the 34 EGFr on the NOTCH3 extracellular domain (N3ECD) are a typical mutation of CADASIL. On the other hand, atypical mutations including cysteine sparing mutation, null mutation, homozygous mutation, and other associate genes are also reported. From the viewpoint of gain of function apart from Notch signaling or loss of function of Notch signaling, we review the research article about CADASIL and summarized the pathogenesis of small vessel, stroke, and dementia in this disease.

Total hip arthroplasty (THA) broaching involves impacting a broach handle with a mallet, facilitating force transmission to progress broaches into the femoral medullary canal. Limited surgical access during direct anterior THAs increases off-axis forces, potentially contributing to tissue damage. The aim was to characterise impactions during broaching. In a cadaver lab, movement of handle, femur and instrumented mallet was tracked during direct-anterior approach (DAA) and posterior approach (PA). Mallet velocity, broach displacement and input energy were calculated. Following the cadaver lab, different impaction strategies were investigated using bone simulants for a simulated DAA. The effects of reduced mallet velocity inputs and the influence of different impaction locations on the broach handle strike plate were investigated. To seat the broach in cadaveric bone, lower impaction energy (-59%) and number of strikes (-53%) were observed during PA compared to DAA. Suboptimal broach progression was reached in bone simulant at low mallet velocities (3.1 ± 0.3 m/s). Impacting the strike plate\'s upper part caused larger deflections (p < 0.001) of the Sawbones femur which suggested that higher off axis forces occurred. Awareness of reduced load transmission during DAA broaching using off-axis broach handles, compared to the traditional PA, could help promoting a more efficient and careful impaction strategy in surgeries.