UNASSIGNED:这项研究的主要目的是研究核苷酸类似物GS-441524与3C样蛋白酶抑制剂GC376联合治疗自然获得性猫传染性腹膜炎(FIP)的功效,并测试它们的组合是否缩短了给药期并提高了治愈率。
未经批准:总共,46只FIP感染的猫被纳入本实验,包括36例湿FIP(29例腹部积液,六个胸腔积液,和一个胸腔+腹腔积液),和10与干FIP。猫的年龄为3至96个月。胸腔积液+腹腔积液,从受影响的猫收集淋巴结穿刺液和肾周穿刺液进行qPCR测试,所有46只猫的猫冠状病毒(FCoV)均呈阳性。将猫分成不同的剂量组,全部治疗4周:第1组(GS-441524,5mg/kg。sc.q.24h;GC376,20mg/kg。sc.q.12h),第2组(GS-441524,2.5mg/kg。sc.q.24h;GC376,20mg/kg。sc.q.12h),第3组(GS-441524,2.5mg/kg。sc.q.24h;GC376,10mg/kg。sc.q.12h),和第4组(GS-441524,5mg/kg。sc.q.24h;GC376,10mg/kg。sc.q.12h)。
未经评估:4周联合治疗后,46只猫中有45只(97.8%)存活下来,其中43例临床正常。两只猫需要更长的治疗时间(7至12周)才能完全康复。截至发稿时(审判结束后10个月),所有45只猫都活着,没有观察到复发。
UNASSIGNED:GS-441524与GC376联用可安全有效地用于治疗FIP,并将治疗期缩短至4周,具有优异的治愈率。
UNASSIGNED: The main objectives of this study were to investigate the efficacy of the nucleotide analog GS-441524 in combination with the 3C-like protease inhibitor
GC376 for the treatment of naturally aquired feline infectious peritonitis (FIP) and to test whether their combination shortens the dosing period and improves the cure rate.
UNASSIGNED: In total, 46 FIP-affected cats were enrolled in this experiment, including 36 with wet FIP (29 with abdominal effusion, six with thoracic effusion, and one with thoracic+abdominal effusion), and 10 with dry FIP. The cats were aged from 3 to 96 months. Thoracic+abdominal effusion, lymph-node puncture fluid and perirenal puncture fluid was collected from the affected cats for qPCR testing, and all 46 cats were positive for feline coronavirus (FCoV). The cats divided into different dose groups, all treated for 4 weeks: group 1 (GS-441524, 5 mg/kg.sc.q.24 h; GC376, 20 mg/kg.sc.q.12 h), group 2 (GS-441524, 2.5 mg/kg.sc.q.24 h;
GC376, 20 mg/kg.sc.q.12 h), group 3 (GS-441524, 2.5 mg/kg.sc.q.24 h;
GC376, 10 mg/kg.sc.q.12 h), and group 4 (GS-441524, 5 mg/kg.sc.q.24 h;
GC376, 10 mg/kg.sc.q.12 h).
UNASSIGNED: After the 4-week combination treatment, 45 of the 46 (97.8%) cats survived, and 43 of those became clinically normal. Two cats required longer (7 to 12 weeks) treatment to achieve full recovery. As of writing (10 months after completion of the trial), all 45 cats were alive and no relapse was observed.
UNASSIGNED: GS-441524 combined with
GC376 can be safely and effectively used to treat FIP and reduces the treatment period to 4 weeks, with an excellent cure rate.