GASTROINTESTINAL SURGERY

胃肠外科
  • 文章类型: Case Reports
    Neuroendocrine tumors (NETs) are rare, slow-growing tumors originating from the diffuse neuroendocrine cell system, predominantly affecting the digestive tract. Small bowel neuroendocrine tumors (SBNETs) may present with nonspecific symptoms, such as abdominal pain, or with intermittent intestinal obstruction. This case outlines the diagnostic journey of a septuagenarian male with prolonged abdominal symptoms and weight loss. Despite extensive investigation, a definitive cause remained elusive. Recurrent partial intestinal obstruction led to surgical exploration and segmental resection. Pathology confirmed a NET. The case underscores the importance of considering intestinal neoplasia in older patients with recurrent partial small bowel obstruction.
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  • 文章类型: Case Reports
    自发性腹膜被描述为由于非创伤性病因而在腹膜腔中收集血液。文献中常见的原因包括脾,肝脏和妇科病理学。自发性腹膜积血患者通常表现为非特异性迟钝腹痛。自发性腹膜只能通过放射学诊断,如果不及时治疗,威胁生命.表现为自发性腹膜的胃肠道间质瘤(GIST)破裂是罕见的事件。胃GIST表现为模糊的腹痛,并发症包括黑便,阻塞和破裂。这是一位60多岁的男性患者的报告,他表现出急性腹痛。腹部对比增强CT显示腹膜,来源不明。诊断性腹腔镜检查显示胃外生性肿块出血,被切除了。因此,早期诊断,正确的影像学检查和及时治疗具有良好的结局。
    Spontaneous haemoperitoneum is described as a collection of blood in the peritoneal cavity due to non-traumatic aetiology. Common causes in the literature include splenic, hepatic and gynaecological pathology. Patients with spontaneous haemoperitoneum usually present with non-specific dull aching abdominal pain. Spontaneous haemoperitoneum can only be radiologically diagnosed and, if not treated in time, is life threatening. Rupture of a gastrointestinal stromal tumour (GIST) presenting as a spontaneous haemoperitoneum is a rare event. Gastric GIST presents as ambiguous abdominal pain, complications of which include melena, obstruction and rupture. This is a report of a male patient in his early 60s who presented with acute abdominal pain. A contrast-enhanced CT of the abdomen showed haemoperitoneum with an unknown source of origin. Diagnostic laparoscopy showed a bleeding exophytic mass arising from the stomach, which was resected. Thus, early diagnosis with proper imaging and prompt treatment has a favourable outcome.
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  • 文章类型: Journal Article
    目的:预后评分需要波动值,如呼吸频率,不适合追溯审计。因此,本研究旨在开发和验证用于回顾性审核的胃肠道手术相关院内死亡率预测模型.
    方法:从2006年7月至2021年12月在静冈总医院进行的胃肠道手术相关菌血症患者的数据来自前瞻性维护的数据库。排除怀疑具有污染细菌的血培养阳性或缺少实验室数据的患者。其余患者以2:1的比例随机分配到偏差和验证队列中。逻辑回归模型估计了比值比(OR),并创建了住院死亡率的预测模型。使用受试者工作特征(ROC)曲线和校准图评估模型。
    结果:在20,637例胃肠手术中,398导致菌血症。菌血症患者的中位年龄为72岁,男性占66.1%。最常见的病原菌为葡萄球菌(13.9%),其次是拟杆菌(12.4%)和埃希氏菌(11.4%)。多因素logistic回归分析显示肌酐异常(P<0.001,OR=3.39),预后营养指数降低(P<0.001,OR=0.90/单位),年龄≥75岁(P=0.026,OR=2.89)是影响住院患者死亡率的独立预后因素。在验证队列中,预测模型的ROC曲线下面积为0.711。校准图显示,该模型略微高估了验证队列中的死亡率。
    结论:使用年龄,肌酐水平,白蛋白水平,淋巴细胞计数,该模型可以准确预测胃肠道手术相关菌血症感染后的院内死亡率,证明其适用于回顾性审计。
    OBJECTIVE: Prognostic scores require fluctuating values, such as respiratory rate, which are unsuitable for retrospective auditing. Therefore, this study aimed to develop and validate a predictive model for in-hospital mortality associated with gastrointestinal surgery for retrospective auditing.
    METHODS: Data from patients with bacteremia related to gastrointestinal surgery performed at Shizuoka General Hospital between July 2006 and December 2021 were extracted from a prospectively maintained database. Patients suspected of having a positive blood culture with contaminating bacteria or missing laboratory data were excluded. The remaining patients were randomly assigned in a 2:1 ratio to the deviation and validation cohorts. A logistic regression model estimated the odds ratios (ORs) and created a predictive model for in-hospital mortality. The model was evaluated using receiver operating characteristic (ROC) curves and calibration plots.
    RESULTS: Of 20,637 gastrointestinal surgeries, 398 resulted in bacteremia. The median age of patients with bacteremia was 72 years, and 66.1% were male. The most common pathogens were Staphylococcus (13.9%), followed by Bacteroides (12.4%) and Escherichia (11.4%). Multivariable logistic regression showed that creatinine abnormality (P < 0.001, OR = 3.39), decreased prognostic nutritional index (P < 0.001, OR = 0.90/unit), and age ≥ 75 years (P = 0.026, OR = 2.89) were independent prognostic factors for in-hospital mortality. The area under the ROC curve of the predictive model was 0.711 in the validation cohort. The calibration plot revealed that the model slightly overestimated mortality in the validation cohort.
    CONCLUSIONS: Using age, creatinine level, albumin level, and lymphocyte count, the model accurately predicted in-hospital mortality after bacteremia infection related to gastrointestinal surgery, demonstrating its suitability for retrospective audits.
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  • 文章类型: Case Reports
    成人先天性膈疝的表现很少见。Further,大多数病例可归因于Bochdalek和Morgagni疝,中央肌腱疝特别罕见。我们报告了一例成人先天性中央膈疝,表现为大肠梗阻和呼吸衰竭。进行了疝气的开放修复,从而解决了病人的症状。该病例报告强调了成年后先天性膈疝的可能性,以及在这些情况下早期诊断和治疗的重要性。
    Presentation of congenital diaphragmatic hernia in adulthood is rare. Further, most cases are attributable to Bochdalek and Morgagni hernias with central tendon hernias being particularly uncommon. We report a case of central congenital diaphragmatic hernia in an adult presenting as large intestinal obstruction and respiratory failure. Open repair of the hernia was performed, which brought about the resolution of the patient\'s symptoms. This case report highlights the possibility for congenital diaphragmatic hernia to present in adulthood and the importance of early diagnosis and treatment in these situations.
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  • 文章类型: Case Reports
    腹膜受累是胰腺腺癌治疗过程中出现的主要困难之一。事实上,目前,术中腹腔热化疗(HIPEC)作为外科胰腺切除术的辅助手段越来越受到关注,具有预防或治疗目的。有了这个视频,我们报告了1例胰体腺癌,采用全腹腔镜远端脾胰腺切除术,术中HIPEC联合吉西他滨,最初以预防意图施用,根据初步腹膜冲洗细胞学结果阴性。在我们的案例中,HIPEC和手术切除的关联并不影响术后恢复,经过15个月的随访,患者仍然活着,没有疾病复发的迹象。
    Peritoneal involvement represents one of the major difficulties that arise during the treatment of pancreatic adenocarcinoma. In fact, currently, there is a growing interest in the administration of intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC) as an adjunct to surgical pancreatic resection, both with prophylactic or therapeutic intent. With this video, we report a case of pancreatic body adenocarcinoma treated with fully laparoscopic distal splenic pancreatectomy with intraoperative HIPEC with gemcitabine, administered initially with a prophylactic intent, based on a preliminary negative peritoneal washing cytology result. In our case, the association of HIPEC and surgical resection did not affect the postoperative recovery, and after 15 months of follow-up, the patient remains alive and has no signs of disease recurrence.
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  • 文章类型: Journal Article
    目的:这项随机对照试验的目的是评估在有尿潴留风险的男性患者在胃肠道手术中硬膜外麻醉期间早期拔除导尿管是否可行。
    方法:本随机对照试验纳入接受胃癌或结肠癌根治术的男性患者。患者以1:1随机分为2组:早期组,其中在术后第二天或第三天拔除硬膜外导管之前拔除导尿管,和后期小组,其中拔除硬膜外导管后拔除导尿管。随机化调整因素为年龄(≥65岁或<65岁)和手术部位(胃或结肠)。主要终点是尿潴留。次要终点是尿路感染的发生率和术后住院时间。
    结果:在2020年3月至2024年2月之间招募了73名患者,分为早期(n=37)和晚期(n=36)组。4名患者在随机分组后撤回了他们的同意书。意向治疗分析显示,早期组4例(11.1%)和晚期组1例(3.0%)发生尿潴留(P=0.20)。晚期尿路感染1例(3.0%)。两组的中位术后住院时间均为9天。
    结论:在接受硬膜外麻醉的胃肠手术的男性患者中,早期拔除导尿管可在预期可接受范围内增加尿潴留。
    背景:UMIN000040468,注册日期:2020年5月21日。
    OBJECTIVE: The purpose of this randomized controlled trial was to evaluate whether early urinary catheter removal is feasible during epidural anesthesia during gastrointestinal surgery in male patients at high risk for urinary retention.
    METHODS: Male patients who underwent radical surgery for gastric or colon cancer were enrolled in this randomized controlled trial. Patients were randomized 1:1 into 2 groups: the early group, in which the urinary catheter was removed before removal of the epidural catheter on the second or third postoperative day, and the late group, in which the urinary catheter was removed after removal of the epidural catheter. The randomization adjustment factors were age (≥ 65 or < 65 years) and operative site (gastric or colon). The primary endpoint was urinary retention. The secondary endpoints were the incidence of urinary tract infection and length of postoperative hospital stay.
    RESULTS: Seventy-three patients were enrolled between March 2020 and February 2024 and assigned to the Early (n = 37) and Late (n = 36) groups. Four patients withdrew their consent after randomization. The intention-to-treat analysis showed that urinary retention occurred in 4 patients (11.1%) in the early group and 1 patient (3.0%) in the late group (P = 0.20). Urinary tract infection occurred in 1 patient (3.0%) in the late group. The median postoperative hospital stay was 9 days in both groups.
    CONCLUSIONS: Early urinary catheter removal in male patients undergoing gastrointestinal surgery with epidural anesthesia could increase urinary retention within the expected acceptable range.
    BACKGROUND: UMIN000040468, Date of registration: May 21, 2020.
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  • 文章类型: Journal Article
    手术部位感染(SSI),尽管不常见,严重影响护理质量。本文致力于研究在资源有限的情况下,在单个机构中涉及胃肠道(GI)的外科手术干预后,SSI的预测因素。
    在2015年6月至2022年6月的7年间,对接受胃肠道手术并发生SSI的患者与未受影响的病例对照队列进行回顾性匹配。伤口培养的标准化技术,细菌分离物的实验室评估,并采用抗生素药敏试验。采用Logistic回归分析探讨与术后30dSSI发生相关的预测因素。
    共纳入525例接受胃肠外科手术的患者,其中,86例(16.4%)发展为SSI,大部分为浅层(74.4%)。大肠杆菌是最常见的细菌(54.4%),观察到高百分比的多药耐药生物(63.8%)。在多元Cox回归分析中,文盲(赔率比[OR]:40.31;95%置信区间[CI]:9.54-170.26),吸烟(OR:21.15;95%CI:4.63-96.67),糖尿病(OR:5.07;95%CI:2.27-11.35),白细胞增多(OR:2.62;95%CI:1.24-5.53),低蛋白血症(OR:3.70;95%CI:1.35-10.16),污染和肮脏的伤口(OR:6.51;95%CI:1.62-26.09),更长的操作持续时间(OR:1.02;95%CI:1.01-1.03),紧急操作(OR:12.58;95%CI:2.91-54.30),延长抗生素预防时间(OR:3.01;95%CI:1.28-7.10)是SSI的独立危险因素(均p<0.05)。
    这项研究强调了SSI的重要预测因素,包括文盲,吸烟,糖尿病,白细胞增多,低蛋白血症,污染和肮脏的伤口,更长的手术时间,紧急行动,并延长抗生素预防持续时间。识别这些危险因素可以帮助外科医生采取适当的措施来减少术后SSI并提高手术护理质量,特别是在资源有限的情况下,没有明显和严格的政策来降低SSI。
    UNASSIGNED: Surgical site infection (SSI), albeit infrequent, drastically impacts the quality of care. This article endeavors to investigate the predictive factors of SSIs following surgical interventions that involve the gastrointestinal (GI) tract within a single institution in a resource-limited setting.
    UNASSIGNED: Over seven years from June 2015 to June 2022, patients who underwent GI surgery and developed SSI were retrospectively matched with an unaffected case-control cohort of patients. Standardized techniques for wound culture, laboratory evaluation of bacterial isolates, and antibiotic susceptibility tests were employed. Logistic regression analysis was utilized to investigate the predictive factors associated with 30-day postoperative SSI occurrence.
    UNASSIGNED: A total of 525 patients who underwent GI surgical procedures were included, among whom, 86 (16.4%) developed SSI and the majority of SSIs were superficial (74.4%). Escherichia coli was the most commonly isolated bacterium (54.4%), and a high percentage of multidrug-resistant organisms were observed (63.8%). In multivariate Cox regression analysis, illiteracy (Odds ratio [OR]:40.31; 95% confidence interval [CI]: 9.54-170.26), smoking (OR: 21.15; 95% CI: 4.63-96.67), diabetes (OR: 5.07; 95% CI: 2.27-11.35), leukocytosis (OR: 2.62; 95% CI: 1.24-5.53), hypoalbuminemia (OR: 3.70; 95% CI: 1.35-10.16), contaminated and dirty wounds (OR: 6.51; 95% CI:1.62-26.09), longer operation duration (OR: 1.02; 95% CI: 1.01-1.03), emergency operations (OR: 12.58; 95% CI: 2.91-54.30), and extending antibiotic prophylaxis duration (OR: 3.01; 95% CI: 1.28-7.10) were the independent risk factors for SSI (all p < 0.05).
    UNASSIGNED: This study highlights significant predictors of SSI, including illiteracy, smoking, diabetes, leukocytosis, hypoalbuminemia, contaminated and dirty wounds, longer operative time, emergency operations, and extending antibiotic prophylaxis duration. Identifying these risk factors can help surgeons adopt appropriate measures to reduce postoperative SSI and improve the quality of surgical care, especially in a resource-limited setting with no obvious and strict policy for reducing SSI.
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  • 文章类型: Case Reports
    我们介绍了一例胆道出血作为潜在胆管癌的主要表现。一名50多岁的男子最初带着Quincke\的三合会被送往紧急情况,RUQ疼痛,黄疸和UGI出血。胆道出血的最初诊断是在内镜逆行胰胆管造影术(ERCP)上进行的,但是血液的存在和胆道血块的复发性阻塞使得潜在的诊断极其困难,导致患者有4个ERCP,1spyglass和多个CT和磁共振胰胆管造影。最终,患者在没有组织诊断的情况下接受了Whipple手术,在组织病理学上确认胆管癌。该病例强调了在胆道出血背景下诊断潜在恶性肿瘤的困难,多学科会议讨论的好处,以支持重要的干预措施,并且在管理非典型演示文稿时需要谨慎和好奇。
    We present a case of haemobilia as a primary presentation for underlying cholangiocarcinoma. A man in his 50s initially presented to emergency with Quincke\'s triad, RUQ pain, jaundice and UGI bleeding. The initial diagnosis of haemobilia was made on endoscopic retrograde cholangiopancreatography (ERCP) on primary presentation, but the presence of blood and the recurrent clot obstruction of the biliary tract made the underlying diagnosis extremely difficult, resulting in the patient having 4 ERCP, 1 spyglass and multiple CTs and magnetic resonance cholangiopancreatography. Eventually, the patient underwent a Whipple\'s procedure without tissue diagnosis, confirming cholangiocarcinoma on histopathology. This case emphasises the difficulty of diagnosis of underlying malignancy in the setting of haemobilia, the benefit of multidisciplinary meeting discussions to support significant interventions and the need to be cautious and curious when managing atypical presentations.
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  • 文章类型: Journal Article
    肠套叠在成人中很少见,使其成为具有挑战性且经常延迟的诊断。患者可能会出现非特异性和亚急性腹部症状。腹部CT是最敏感的成像方式,通常需要诊断肠套叠。与儿科人群相比,成人肠套叠最常与作为导点的病理性病变相关。在成年人中,导联点通常继发于恶性肿瘤,虽然良性病变也有牵连。因此,选择性切除的外科治疗是成人治疗的主要手段.我们描述了一例罕见的继发于大型回肠脂肪瘤的成人回肠盲肠肠套叠,在偏远的西澳大利亚州医院成功进行了剖腹手术和切除术。在农村和偏远的澳大利亚,CT成像和熟练的普通外科医师的日益普及使此类病例的诊断和手术管理无需医院间转移。
    Intussusception is rare in adults, making it a challenging and often delayed diagnosis. Patients may re-present with non-specific and subacute abdominal symptoms. Abdominal CT is the most sensitive imaging modality and is often required to make the diagnosis of intussusception. In contrast to the paediatric population, intussusception in adults is most often associated with a pathological lesion acting as a lead point. In adults, the lead point is often secondary to malignancy, though benign lesions can also be implicated. As such, surgical management with selective resection is the mainstay of treatment in adults. We describe a rare case of ileocaecal intussusception in an adult secondary to a large ileocaecal lipoma, successfully treated with laparotomy and resection in a remote Western Australian hospital. The increasing availability of CT imaging and skilled general surgeons in rural and remote Australia allows for the diagnosis and surgical management of such cases without inter-hospital transfer.
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  • 文章类型: Case Reports
    黄色肉芽肿性胆囊炎是一种罕见的胆囊慢性炎症性疾病,伴有穿孔等并发症,致密的粘连和瘘管。我们介绍了一例20多岁的女性患者,该患者在3个月内出现了3次复发性胆囊炎发作。她的病史包括内镜逆行胰胆管造影术,用于治疗胆总管结石引起的阻塞性黄疸。由于在她初次入院时不可能进行紧急胆囊切除术,她被列入择期手术名单。腹腔镜检查发现囊性包块累及网膜,横结肠,十二指肠和肝脏以及可疑的胆囊阑尾瘘的发现。行腹腔镜胆囊切除术和阑尾切除术。急性胆囊炎患者应尽早入院行腹腔镜胆囊切除术,以防止手术难度和相关并发症的发生。此病例表现为与黄色肉芽肿性胆囊炎相关的胆囊阑尾瘘,强调必须遵守国家指南来管理急性结石性胆囊炎。
    Xanthogranulomatous cholecystitis is a rare chronic inflammatory disease of the gallbladder associated with complications such as perforation, dense adhesions and fistulation. We present a case of a female patient in her 20s who presented with three episodes of recurrent cholecystitis over 3 months. Her medical history included an endoscopic retrograde cholangiopancreatography for obstructive jaundice due to choledocholithiasis. As there was no possibility of performing an urgent cholecystectomy during her initial admission, she was listed for an elective operation. Laparoscopic inspection revealed a pericholecystic mass involving the omentum, transverse colon, duodenum and liver and findings suspicious of a cholecystoappendiceal fistula. Laparoscopic cholecystectomy and appendicectomy were performed. Early index admission laparoscopic cholecystectomy should be performed in patients with acute cholecystitis to prevent higher grades of operative difficulty and associated complications. This case presentation-cholecystoappendiceal fistula associated with xanthogranulomatous cholecystitis-emphasises the necessity of complying with national guidelines in managing acute calculous cholecystitis.
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