背景:角质病是一种感染性角膜炎,角膜感染,这是由真菌引起的。这种疾病是全球眼病的主要原因,至少60%的受影响个体变为单眼盲。
目的:本文献计量分析旨在全面评估现有文献,通过确定关键主题和研究差距,提供对角膜真菌病研究演变的见解。
方法:这项工作使用建模方法LatentDirichletAllocation(LDA)来识别和解释与一组文档中现有类别有关的主题的科学信息。还使用了HJ-Biplot方法来确定分析主题之间的关系,考虑到正在研究的年份。
结果:该文献计量分析是对1992年至2022年之间发表的总共2,599篇科学文章进行的。生产和引用更科学的五个主要国家是美利坚合众国,其次是印度,中国,英国和澳大利亚。研究的前五个主题是病例报告和角膜感染,呈下降趋势;其次是穿透性角膜移植术和角膜手术,抗真菌药物的眼部效应,多年来一直在增加的角膜和患者数据中的基因表达和炎症反应。然而,丝状真菌和特定病原体,抗真菌治疗的研究一直呈下降趋势。
结论:对创新抗真菌药物疗法的进一步研究对于在科学写作中积极应对未来对抗真菌药物的潜在耐药性至关重要。
BACKGROUND: Keratomycosis is a form of infectious keratitis, an infection of the cornea, which is caused by fungi. This disease is a leading cause of ocular morbidity globally with at least 60 % of the affected individuals becoming monocularly blind.
OBJECTIVE: This bibliometric analysis aimed to comprehensively assess the existing body of literature, providing insights of the evolution of keratomycosis research by identifying key themes and research gaps.
METHODS: This work used the modeling method Latent Dirichlet Allocation (LDA) to identify and interpret scientific information on topics concerning existing categories in a set of documents. The HJ-Biplot method was also used to determine the relationship between the analyzed topics, taking into consideration the years under study.
RESULTS: This bibliometric analysis was performed on a total of 2,599 scientific articles published between 1992 and 2022. The five leading countries with more scientific production and citations on keratomycosis were The United States of America, followed by India, China, United Kingdom and Australia. The top five topics studied were Case Reports and Corneal Infections, which exhibited a decreasing trend; followed by Penetrating Keratoplasty and Corneal Surgery, Ocular Effects of Antifungal Drugs, Gene Expression and Inflammatory Response in the Cornea and Patient Data which have been increasing throughout the years. However Filamentous Fungi and Specific Pathogens, and Antifungal Therapies research has been decreasing in trend.
CONCLUSIONS: Additional investigation into innovative antifungal drug therapies is crucial for proactively tackling the potential future resistance to antifungal agents in scientific writing.