■通过增强谱域光学相干断层扫描(EDI-OCT)表征Vogt-Koyanagi-Harada(VKH)疾病眼底的动态变化,并探讨视觉预后的预测因素。
■在这项回顾性队列研究中,我们对2013年1月至2022年4月转诊到我们葡萄膜炎中心的2152例VKH患者进行了筛查;纳入151例新发VKH患者(299只眼)和82例健康对照(164只眼).基线时眼底的表现,1个月,3个月,和治疗后12个月进行分析,并评估其与视觉预后的相关性。
■基线时出现视网膜脱离(RD)(97.3%)和视盘肿胀(100%)后,在第1个月观察到视网膜再附着(81.6%)和视网膜色素上皮(RPE)的颗粒高反射沉积(61.5%)。最后注意到伴随交错区衰减的RPE和椭球区重排(57.9%)。在基线和第1个月,患者的脉络膜厚度均高于对照组(均P<0.001)。最佳矫正视力(BCVA)(最小分辨率角度的对数[logMAR])(P<0.001;OR,4.01),视网膜下纤维蛋白样渗出物(P<0.001;OR,3.9)和RPE折叠(p=0.001;OR,2.39)在基线时,和第1个月的RD(P<0.001;OR,3.42)与视力预后相关。
■治疗后的新发VKH患者在12个月期间表现出眼底特别是外视网膜的动态变化。BCVA,视网膜下纤维蛋白样渗出物,和RPE折叠在基线,和5月1日的RD作为视觉预后的预测因子。
UNASSIGNED: To characterize the dynamic changes of
fundus in Vogt-Koyanagi-Harada (VKH) disease through enhanced spectral-domain optical coherence tomography (EDI-OCT) and explore the predictors of visual prognosis.
UNASSIGNED: In this retrospective cohort study, a total of 2152 VKH patients referred to our uveitis center from January 2013 to April 2022 were screened; 151 new-onset VKH patients (299 eyes) and 82 healthy controls (164 eyes) were included. The manifestations of
fundus at baseline, 1 month, 3 months, and 12 months after treatment were analysed and their relevance to visual prognosis were evaluated.
UNASSIGNED: After retinal detachment (RD) (97.3%) and optic disc swelling (100%) presented at baseline, retinal reattachment (81.6%) and the granular hyperreflective depositions at the retinal pigment epithelium (RPE) (61.5%) were observed at month 1. The RPE and ellipsoid zone rearrangement accompanying interdigitation zone attenuation (57.9%) was noted finally. Choroidal thickness of patients was higher than that in the controls at baseline and month 1 (both P < 0.001). Best-corrected visual acuity (BCVA) (logarithm of the minimum angle of resolution [logMAR]) (P < 0.001; OR, 4.01), subretinal fibrinoid exudate (P < 0.001; OR, 3.9) and RPE folds (p = 0.001; OR, 2.39) at baseline, and the RD at month 1 (P < 0.001; OR, 3.42) were associated with visual prognosis.
UNASSIGNED: New-onset VKH patients after treatment exhibited dynamic changes in the
fundus especially the outer retina during a 12-month period. The BCVA, subretinal fibrinoid exudate, and RPE folds at baseline, and RD at month May 1, serve as predictors of visual prognosis.