■这项研究的目的是调查视觉功能与严重程度分级之间的关联,角膜散射,Fuchs内皮角膜营养不良(FECD)患者的高阶像差(HOAs)。
■这项观察性病例系列研究包括27名FECD患者的49只眼和10名健康人的10只眼。我们使用Landolt-C和早期治疗糖尿病视网膜病变研究图评估了校正的远距视力(CDVA),并使用CSV-1000E图和CSV-1000RN字母图评估了对比敏感度。我们分析了视觉功能与解释变量之间的关联,包括年龄,修改后的克拉赫默等级,中央角膜厚度(CCT),基于眼前节光学相干断层扫描(AS-OCT)的分级,HOAs,眼内散光,和角膜密度测定。我们还进行了接收器工作特性(ROC)分析,以确定视觉功能降低的角膜密度测定阈值。
■视觉功能与改良的克拉赫默等级之间存在显着关联,CCT,基于AS-OCT的等级,HOAs,眼内散光,和角膜密度测定。改良的Krachmer等级≥3被确定为视觉功能降低的阈值。多因素分析显示角膜光密度测定与所有视功能参数显著相关,和HOAs与CDVA显着相关,但与对比敏感度无关。ROC分析显示,0至2mm≥10灰度单位(GSU)的后层角膜密度测定,被确定为视觉功能下降的阈值。
■HOAs,向前和向后的光散射影响视觉功能,向后的光散射是最有影响力的。在FECD患者中,改良Krachmer分级≥3级和角膜光密度测定≥10GSU是视觉障碍的阈值.
UNASSIGNED: The purpose of this study was to investigate the associations between visual function and severity grading, corneal scatter, or higher-order aberrations (HOAs) in patients with Fuchs endothelial corneal dystrophy (FECD).
UNASSIGNED: This observational case series study included 49 eyes of 27 patients with FECD and 10 eyes of 10 healthy individuals. We evaluated corrected distance visual acuity (CDVA) using Landolt-C and Early Treatment Diabetic Retinopathy Study charts and contrast sensitivity using the CSV-1000E chart and CSV-1000RN letter chart. We analyzed the associations between visual function and explanatory variables, including age, modified Krachmer grade, central corneal thickness (CCT), anterior segment optical coherence tomography (AS-OCT)-based grade, HOAs, intraocular straylight, and corneal densitometry. We additionally conducted receiver operating characteristic (ROC) analysis to identify the corneal densitometry thresholds for decreased visual function.
UNASSIGNED: There were significant associations between visual function and the modified Krachmer grade, CCT, AS-OCT-based grade, HOAs, intraocular straylight, and corneal densitometry. A modified Krachmer grade ≥ 3 was identified as a threshold for decreased visual function. Multivariate analysis showed that corneal densitometry was significantly associated with all visual function parameters, and HOAs were significantly associated with CDVA but not with contrast sensitivity. ROC analysis revealed that corneal densitometry of the posterior layer at 0 to 2 mm ≥ 10 grayscale units (GSU), was identified as a threshold for decreased visual function.
UNASSIGNED: HOAs, forward and backward light scatter affected visual function, with backward light scatter being the most influential. In patients with FECD, modified Krachmer grade ≥ 3 and corneal densitometry ≥ 10 GSU were thresholds for visual disturbance.