胰岛素样生长因子2（IGF-2）最近已被证明可以减轻大鼠和小鼠模型中的抑郁样行为。然而,其作为外周生物标志物的潜在作用尚未在抑郁症中得到评估.要做到这一点，我们在抑郁组(n=51)和健康对照组(n=48)中测定了血浆IGF-2和IGF家族的其他成员,如结合蛋白(IGFBP-1,IGFBP-3,IGFBP-5和IGFBP-7).在其中一些患者(n=15)中，我们在使用抗抑郁药治疗一段时间（19±6天）后测量了这些蛋白质。汉密尔顿抑郁量表（HDRS）和自评量表（SAAS）用于测量抑郁严重程度和快感缺乏，分别。通过迷你精神状态检查（MMSE）测试和自由和提示选择性提醒测试（FCSRT）的记忆来评估一般认知状态。在抑郁组中，IGF-2和IGFBP-7的水平均显著升高；然而，只有IGF-2在按年龄和性别校正后仍然显著升高。另一方面,治疗后IGF-2、IGFBP-3和IGFBP-5水平明显下降,而仅IGFBP-7显著升高。因此,IGF家族的外周变化及其对抗抑郁药的反应可能代表抑郁症患者大脑水平的改变.
The Insulin-like growth factor 2 (IGF-2) has been recently proven to alleviate depressive-like behaviors in both rats and mice models. However, its potential role as a peripheral biomarker has not been evaluated in depression. To do this, we measured plasma IGF-2 and other members of the IGF family such as Binding Proteins (IGFBP-1, IGFBP-3, IGFBP-5 and IGFBP-7) in a depressed group of patients (n = 51) and in a healthy control group (n = 48). In some of these patients (n = 15), we measured these proteins after a period (19 ± 6 days) of treatment with antidepressants. The Hamilton Depressive Rating Scale (HDRS) and the Self-Assessment Anhedonia Scale (SAAS) were used to measure depression severity and anhedonia, respectively. The general cognition state was assessed by the Mini-Mental State Examination (MMSE) test and memory with the Free and Cued Selective Reminding Test (FCSRT). The levels of both IGF-2 and IGFBP-7 were found to be significantly increased in the depressed group; however, only IGF-2 remained significantly elevated after correction by age and sex. On the other hand, the levels of IGF-2, IGFBP-3 and IGFBP-5 were significantly decreased after treatment, whereas only IGFBP-7 was significantly increased. Therefore, peripheral changes in the IGF family and their response to antidepressants might represent alterations at the brain level in depression.
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