Fortified blended food

  • 文章类型: Journal Article
    背景:在卢旺达,在过去的五年中,儿童发育迟缓的患病率略有下降,从2015年的38%到2020年的33%左右。显然,卢旺达减少儿童发育迟缓的多部门方法是否与现有的科学知识相一致。该研究旨在使用机器学习分类器检查卢旺达两年以下国家营养计划对减少发育迟缓的好处。
    方法:使用来自卢旺达国土安全部2015-2020年、MEIS和LODA家庭调查的数据。通过评价预测两岁以下儿童发育迟缓的最佳方法,对五种机器学习算法进行了建模:支持向量机,Logistic回归,K-NearNeighbor,随机森林,决策树该研究估计了Cox比例风险模型的风险比,并绘制了Kaplan-Meier曲线,以比较计划受益人和非受益人之间发育迟缓的幸存者风险。Logistic回归用于确定与发育迟缓减少相关的营养计划。Precision,召回,F1得分,准确度,和曲线下面积(AUC)是用于评估每个分类器的性能以找到最佳分类器的度量。
    结果:根据提供的数据,研究表明,儿童早期发展(ECD)计划(p值=0.041),营养敏感直接支持(NSDS)计划(p值=0.03),ubudehe类别(p值=0.000),厕所设施(p值=0.000),产前护理(ANC)4次就诊(p值=0.002),强化混合食品(FBF)计划(p值=0.038)和疫苗接种(p值=0.04)被发现是卢旺达两名以下儿童发育迟缓减少的重要预测因素。此外,幼儿发展的受益者(p<0.0001),营养敏感性直接支持(p=0.0055),产前护理(p=0.0343),强化混合食品(p=0.0136)和疫苗接种(p=0.0355)的发育迟缓风险低于非受益人。最后,随机森林比其他分类器表现更好,准确率为83.7%,召回分数为90.7%,F1得分87.1%,准确率为83.9%,AUC评分为82.4%。
    结论:儿童早期发展(ECD)计划,接受营养敏感直接支持(NSDS)计划,关注财富最低的五分之一家庭(乌布德赫类别),卫生设施,四次拜访医疗保健提供者,接受强化混合食品(FBF),并接受所有必要的疫苗是什么决定了在卢旺达的17个地区中,两个地区的发育迟缓的减少。最后,与其他型号相比,随机森林被证明是最好的机器学习(ML)分类器。随机森林是预测两岁以下儿童发育迟缓减少状况的最佳分类器。
    BACKGROUND: In Rwanda, the prevalence of childhood stunting has slightly decreased over the past five years, from 38% in 2015 to about 33% in 2020. It is evident whether Rwanda\'s multi-sectorial approach to reducing child stunting is consistent with the available scientific knowledge. The study was to examine the benefits of national nutrition programs on stunting reduction under two years in Rwanda using machine learning classifiers.
    METHODS: Data from the Rwanda DHS 2015-2020, MEIS and LODA household survey were used. By evaluating the best method for predicting the stunting reduction status of children under two years old, the five machine learning algorithms were modelled: Support Vector Machine, Logistic Regression, K-Near Neighbor, Random Forest, and Decision Tree. The study estimated the hazard ratio for the Cox Proportional Hazard Model and drew the Kaplan-Meier curve to compare the survivor risk of being stunted between program beneficiaries and non-beneficiaries. Logistic regression was used to identify the nutrition programs related to stunting reduction. Precision, recall, F1 score, accuracy, and Area under the Curve (AUC) are the metrics that were used to evaluate each classifier\'s performance to find the best one.
    RESULTS: Based on the provided data, the study revealed that the early childhood development (ECD) program (p-value = 0.041), nutrition sensitive direct support (NSDS) program (p-value = 0.03), ubudehe category (p-value = 0.000), toilet facility (p-value = 0.000), antenatal care (ANC) 4 visits (p-value = 0.002), fortified blended food (FBF) program (p-value = 0.038) and vaccination (p-value = 0.04) were found to be significant predictors of stunting reduction among under two children in Rwanda. Additionally, beneficiaries of early childhood development (p  < .0001), nutrition sensitive direct support (p = 0.0055), antenatal care (p = 0.0343), Fortified Blended Food (p = 0.0136) and vaccination (p = 0.0355) had a lower risk of stunting than non-beneficiaries. Finally, Random Forest performed better than other classifiers, with precision scores of 83.7%, recall scores of 90.7%, F1 scores of 87.1%, accuracy scores of 83.9%, and AUC scores of 82.4%.
    CONCLUSIONS: The early childhood development (ECD) program, receiving the nutrition sensitive direct support (NSDS) program, focusing on households with the lowest wealth quintile (ubudehe category), sanitation facilities, visiting health care providers four times, receiving fortified blended food (FBF), and receiving all necessary vaccines are what determine the stunting reduction under two among the 17 districts of Rwanda. Finally, when compared to other models, Random Forest was shown to be the best machine learning (ML) classifier. Random forest is the best classifier for predicting the stunting reduction status of children under two years old.
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  • 文章类型: Journal Article
    强化混合食品(FBF)是磨碎的谷物和豆类的微量营养素强化混合物,代表了最常见的微量营养素强化食品助剂。由于缺乏治疗营养不良的功效,FBFs受到批评,也有人建议替代商品,比如高粱和豆豆,代替玉米和大豆进行调查。微量营养素强化食品援助试点项目(MFFAPP)坦桑尼亚功效研究是经济、processing,感官,和营养FBF的研究和开发。MFFAPP坦桑尼亚是一个20周,2016年2月至7月进行了部分随机分组设计,纳入坦桑尼亚马拉地区身高体重z评分>-3,血红蛋白浓度<10.3mg/dL的6~53mo儿童.干预措施是新配方的补充喂养,膨化FBFs(白高粱-豆豆品种1,白高粱-豆豆品种2,红高粱-豆豆,白色高粱-大豆混合物,和玉米-大豆混合物14)与玉米大豆混合物(CSB+)相比,目前美国国际开发署分发的玉米大豆混合物,和一个无FBF接收控制。筛选的参与者(n=2050)按年龄组(6-23和24-53个月)进行分层,并分配给每两周提供的7个FBF集群中的1个。在第0、10和20周每10周测量生化和人体测量数据。这项研究的主要目标是确定新制定的,挤压玉米-,大豆-,高架,与CSB+相比,以cow豆为基础的FBFs产生等效的维生素A或铁结果。还检查了人体测量结果的变化。MFFAPP坦桑尼亚功效研究的结果将使粮食援助生产者和分销商了解挤压高粱和cow豆的FBF是否是改善营养不良者健康的可行选择。该试验在clinicaltrials.gov注册为NCT02847962。
    Fortified blended foods (FBFs) are micronutrient-fortified blends of milled cereals and pulses that represent the most commonly distributed micronutrient-fortified food aid. FBFs have been criticized due to lack of efficacy in treating undernutrition, and it has also been suggested that alternative commodities, such as sorghum and cowpea, be investigated instead of corn and soybean. The Micronutrient Fortified Food Aid Pilot Project (MFFAPP) Tanzania efficacy study was the culmination of economic, processing, sensory, and nutrition FBF research and development. MFFAPP Tanzania was a 20-wk, partially randomized cluster design conducted between February and July 2016 that enrolled children aged 6-53 mo in the Mara region of Tanzania with weight-for-height z scores >-3 and hemoglobin concentrations <10.3 mg/dL. The intervention was complementary feeding of newly formulated, extruded FBFs (white sorghum cowpea variety 1, white sorghum-cowpea variety 2, red sorghum-cowpea, white sorghum-soy blend, and corn-soy blend 14) compared with Corn Soy Blend Plus (CSB+), a current US Agency for International Development-distributed corn-soy blend, and a no-FBF-receiving control. Screened participants (n = 2050) were stratified by age group (6-23 and 24-53 mo) and allocated to 1 of 7 FBF clusters provided biweekly. Biochemical and anthropometric data were measured every 10 wk at weeks 0, 10, and 20. The primary objectives of this study were to determine whether newly formulated, extruded corn-, soy-, sorghum-, and cowpea-based FBFs result in equivalent vitamin A or iron outcomes compared with CSB+. Changes in anthropometric outcomes were also examined. Results from the MFFAPP Tanzania Efficacy Study will inform food aid producers and distributers about whether extruded sorghum- and cowpea-based FBFs are viable options for improving the health of the undernourished. This trial was registered at clinicaltrials.gov as NCT02847962.
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  • 文章类型: Journal Article
    玉米大豆混合(CSB)粥通常用油制备,用于治疗中度急性营养不良(MAM)。最近的评论建议将30克油与100克CSB一起使用,以增加能量密度和微量营养素吸收。这项研究评估了旨在实现准备好的粥中目标油:CSB比率的计划变更的有效性和成本效益。MAM补充喂养计划中儿童的照顾者被分配到三组:对照组每月接受1L油的口粮,8千克散装CSB,以及社会和行为改变沟通(SBCC);干预组接受2.6L油,8千克CSB散装提供(第1组)或4个2千克包装印刷信息(第2组),和增强的SBCC强调目标油:CSB比。与对照相比,两个干预组每100克CSB的平均添加油量较高(18克,p<0.01,和13g,p=0.04,分别在第1组和第2组中较高),达到或超过目标比率的可能性更大(第1组和第2组分别为28.4,p<0.01和12.7,p=0.02)。在第1组中,每个护理人员达到目标比率的成本最有利(第1组中为391美元,第2组中为527美元,对照组为1,666美元)。增强的SBCC与增加的油配给相结合,导致在补充饲喂计划中CSB粥中油的使用量增加。改良包装并没有提高有效性。然而,两种干预措施均比标准方案方案更具成本效益.
    Corn Soy Blend (CSB) porridge is commonly prepared with oil for treatment of moderate acute malnutrition (MAM). A recent review recommended that 30 g of oil be used with 100 g of CSB to increase energy density and micronutrient absorption. This study assessed the effectiveness and cost-effectiveness of program changes aimed at achieving that target oil:CSB ratio in prepared porridge. Caregivers of children in MAM supplementary feeding programs were assigned to three groups: a control group received monthly rations of 1 L oil, 8 kg CSB in bulk, and social and behavior change communication (SBCC); intervention groups received 2.6 L oil, 8 kg CSB provided either in bulk (Group 1) or four 2-kg packages with printed messages (Group 2), and enhanced SBCC emphasizing the target oil:CSB ratio. Compared to the control, both intervention groups had higher mean added oil per 100 g CSB (18 g, p < 0.01, and 13 g, p= 0.04, higher in groups 1 and 2, respectively), and greater odds of meeting or exceeding the target ratio (28.4, p< 0.01, and 12.7, p= 0.02, in groups 1 and 2, respectively). Cost per caregiver reaching the target ratio was most favorable in Group 1 ($391 in Group 1, $527 in Group 2, and $1,666 in the control). Enhanced SBCC combined with increased oil ration resulted in increased use of oil in CSB porridge in a supplementary feeding program. Modified packaging did not improve effectiveness. However, both interventions were more cost-effective than standard programming.
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