这项研究探索了对糖部分的心脏代谢反应,以及随后的混合膳食耐受性测试(MMTT)。21名健康青少年(N=10名女性,14.3±0.4年)完成3个实验条件和1个控制条件,以平衡的顺序。这些由不同的饮料组成,以比较300毫升水(对照)的效果,或300毫升水与60克葡萄糖混合,果糖或蔗糖,关于血管功能(血流介导的扩张(FMD),微血管反应性(总高血反应;TRH),和脑血管反应性(CVR)),血样检测尿酸,葡萄糖,甘油三酯和乳酸浓度。FMD在葡萄糖和蔗糖后1小时增加(P<0.001,ES≥0.92),但在果糖和水之后没有变化(P≥0.19,ES≥0.09)。CVR和TRH在所有条件(P>0.57,效应大小(ES)>0.02)下1小时不变。在MMTT之后,所有情况下FMD均受损(P<0.001,ES>0.40),条件之间无差异(P>0.13,ES<0.39)。在所有情况下,微血管TRH均增加(P=0.001,ES=0.88),在MMTT后的所有条件下,CVR均得到保留(P=0.87,ES=0.02)。服用果糖和MMTT后血尿酸浓度升高(P<0.01,ES>0.40)。食用含糖饮料不会导致健康青少年的血管功能障碍;然而,血管和代谢反应依赖于糖部分.新颖性:葡萄糖消耗会急剧增加健康青少年的外周血管功能。急性含糖饮料消费(蔗糖)不会导致不良的血管结局。随着果糖消耗,观察到尿酸升高,这可能会对重复暴露产生影响。
This study explored the cardiometabolic responses to sugar moieties acutely, and following a subsequent mixed meal tolerance test (MMTT). Twenty-one healthy adolescents (N = 10 female, 14.3 ± 0.4 years) completed 3 experimental and 1 control condition, in a counterbalanced order. These consisted of different drinks to compare the effect of 300 mL of water (control), or 300 mL of water mixed with 60 g of glucose, fructose or sucrose, on vascular function (flow-mediated dilation (FMD), microvascular reactivity (total hyperaemic response; TRH), and cerebrovascular reactivity (CVR)), and blood samples for uric acid, glucose, triglycerides and lactate concentrations. FMD increased 1 h after glucose and sucrose (P < 0.001, ES ≥ 0.92) but was unchanged following fructose and water (P ≥ 0.19, ES ≥ 0.09). CVR and TRH were unchanged 1 h following all conditions (P > 0.57, effect size (ES) > 0.02). Following the MMTT, FMD was impaired in all conditions (P < 0.001, ES > 0.40) with no differences between conditions (P > 0.13, ES < 0.39). Microvascular TRH was increased in all conditions (P = 0.001, ES = 0.88), and CVR was preserved in all conditions after MMTT (P = 0.87, ES = 0.02). Blood uric acid concentration was elevated following fructose consumption and the MMTT (P < 0.01, ES > 0.40). Consumption of a sugar sweetened beverage did not result in vascular dysfunction in healthy adolescents; however, the vascular and metabolic responses were dependent on sugar moiety. Novelty: Glucose consumption acutely increases peripheral vascular function in healthy adolescents. Acute sugar sweetened beverage consumption (sucrose) does not result in adverse vascular outcomes. Elevations in uric acid are observed with fructose consumption, which may have implications over repeated exposure.