■我们检验了癫痫的假设,但不是非癫痫,癫痫发作将改善围手术期的共病抑郁和焦虑症状,就像电休克疗法的抗抑郁作用一样.
■我们检查了住院患者的抑郁和焦虑症状,作为常规临床护理的一部分进行连续视频脑电图检查。患者完成了三份问卷,其中包括贝克抑郁量表-II(BDI),蒙哥马利·阿斯伯格抑郁量表(MADRS),和贝克焦虑量表(BAI)入院后,在癫痫发作后的24小时内,然后在最后一次癫痫发作两周后再次发作。
■在癫痫患者中,抑郁和焦虑评分在癫痫发作后24小时内有所改善(BDI变化=24%;MADRS变化=19%;BAI变化=21%),但在2周后恢复至基线.在非癫痫发作的患者中,在精神性非癫痫发作后的24小时内,抑郁和焦虑评分也有所改善(BDI变化=17%,MADRS的变化=27%,BAI的变化=36%)。局灶性发作癫痫患者的抑郁和焦虑评分有更大的改善(BDI=30%,MADRS=22%,BAI=30%)与全身性癫痫发作(BDI=6%,MADRS=12%,BAI=8%)。
■我们得出的结论是,单次癫痫发作可以导致情绪的短暂改善。因为癫痫发作不需要全身性或癫痫性来发挥这种作用,潜在的机制是不确定的。
UNASSIGNED: We tested the hypothesis that epileptic, but not non-epileptic, seizures would produce an improvement in comorbid depression and anxiety symptoms in the peri-ictal period, much like the antidepressant effects of electroconvulsive therapy.
UNASSIGNED: We examined depression and anxiety symptoms in patients admitted to an inpatient unit for continuous video electroencephalography as part of routine clinical care. Patients completed three questionnaires that included the Beck Depression Inventory-II (BDI), Montgomery Asberg Depression Rating Scale (MADRS), and Beck Anxiety Inventory (BAI) after admission, in the 24 h following a seizure, then again 2 weeks after the last seizure.
UNASSIGNED: In patients with epilepsy, depression and anxiety scores improved in the 24 hrs following a seizure (change in BDI = 24%; change in MADRS = 19%; change in BAI = 21%) but returned toward baseline after 2 weeks. In patients with non-epileptic seizures, depression and anxiety scores also improved in the 24 hrs following a psychogenic non-epileptic seizure (change in BDI = 17%, change in MADRS = 27%, change in BAI = 36%). There was a greater improvement in depression and anxiety scores in patients with focal-onset epilepsy (BDI = 30%, MADRS = 22%, BAI = 30%) compared to generalized seizure onset (BDI = 6%, MADRS = 12%, BAI = 8%).
UNASSIGNED: We conclude that single seizures can result in transient improvements in mood. Because seizures need not be generalized or epileptic to exert this effect, the underlying mechanisms are uncertain.