背景:慢性脱髓鞘疾病多发性硬化症(MS)的患病率和功能负担已得到充分证明;然而,对机敏的初始临床过程知之甚少,睡眠,认知,和心理症状。
目的:这项探索性研究,prospective,纵向研究多维地调查了警觉性的发展和进展,睡眠,健身驾驶,以及从头诊断MS后第一年的心理症状。
方法:对25名MS(pwMS)患者进行认知评估,心理上,诊断后不久和一年后使用多导睡眠图,与匹配的健康对照相比。
结果:在疾病的早期阶段,pwMS的心理症状与对照组相当,患者病情在第一个疾病年内没有恶化。一小部分pwMS在诊断后经历了焦虑和抑郁水平的增加。警觉性,持续关注,两组之间的驾驶适应性相当,在这一年中,疲劳水平仍然很低。
结论:本研究强调了一小部分患者在MS初始临床病程中的患者经历。需要进一步的研究来了解MS在更长时期和疾病不同阶段的症状和损伤的进展。
BACKGROUND: The prevalence and functional burden of the chronic demyelinating disease multiple sclerosis (MS) are well documented; however, little is known about the initial clinical course of alertness, sleep, cognitive, and psychological symptoms.
OBJECTIVE: This exploratory, prospective, longitudinal study multidimensionally investigated the development and progression of alertness, sleep, fitness to drive, and psychological symptoms in the first year after de novo MS diagnosis.
METHODS: Twenty-five people with MS (pwMS) were assessed cognitively, psychologically, and using polysomnography soon after diagnosis and one year later, with outcomes compared to matched healthy controls.
RESULTS: In the early stage of the disease, psychological symptoms of pwMS were comparable with those of controls, and patient conditions did not deteriorate within the first disease year. A small percentage of pwMS experienced increased levels of anxiety and depression after diagnosis. Alertness, sustained attention, and fitness to drive were comparable between both groups, and fatigue levels remained low over the course of the year.
CONCLUSIONS: This study highlights patient experiences within the initial clinical course of MS in a small group of patients. Further research is needed to understand the progression of symptoms and impairments in MS over a longer period and in different stages of the disease.