背景:癫痫在婴儿出生后第一年的发病率很高,然而,预后可能有很大差异。尽管已经对婴儿痉挛进行了大量研究,检查婴儿发作性癫痫的研究,不包括婴儿痉挛,保持有限,特别是影响结果的因素。因此,我们的研究旨在阐明癫痫发作控制,发展成果,癫痫婴儿出生后第一年的预后因素,在马来西亚的单中心研究中。
方法:我们检索了在12个月之前经历过癫痫发作并随访超过两年的患者的数据,使用吉兰丹的RajaPerempuanZainabII医院的电子病历,马来西亚东海岸的一个州。我们回顾性回顾了这些记录,并根据最后一次随访评估了临床结果。
结果:在75名患者中,61例(81.3%)实现了良好的癫痫发作控制或缓解。在最后一次随访中,24(32%)表现出发育迟缓,而19(25.3%)显示神经影像学异常。背景脑电图(EEG)活动异常的患者,以及异常的放射学发现,更有可能经历不良的癫痫发作控制和不利的发育结果(P<0.05)。
结论:我们的研究强调大多数癫痫患儿可以达到癫痫发作缓解。然而,癫痫发作控制不佳和发育迟缓与脑电图背景和特征异常有关,以及神经影像学异常。婴儿发作性癫痫的管理可能需要大量资源和精确的干预措施来提高总体结果。
BACKGROUND: Epilepsy has a high incidence among infants during their first year of life, yet the prognosis can vary significantly. Although considerable research has been conducted on infantile spasms, studies examining infantile-onset epilepsy, excluding infantile spasms, remain limited, particularly concerning the factors influencing outcomes. Therefore, our study aims to elucidate seizure control, developmental outcomes, and prognostic factors in infants with epilepsy during their first year of life, within a single-center study in Malaysia.
METHODS: We retrieved data from patients who experienced seizures before age 12 months and were followed for over two years, using electronic patient records at Hospital Raja Perempuan Zainab II in Kelantan, a state in Malaysia\'s east coast. We retrospectively reviewed these records and assessed clinical outcomes based on the last follow-up.
RESULTS: Of 75 patients, 61 (81.3%) achieved good seizure control or remission. At the last follow-up, 24 (32%) exhibited developmental delay, whereas 19 (25.3%) displayed abnormal neuroimaging. Patients with abnormal background electroencephalographic (EEG) activity, as well as abnormal radiological findings, were more likely to experience poor seizure control and unfavorable developmental outcomes (P < 0.05).
CONCLUSIONS: Our study underscores that most infants with epilepsy can achieve seizure remission. However, poor seizure control and developmental delay are associated with abnormal EEG background and characteristics, as well as neuroimaging abnormalities. The management of infantile-onset epilepsies may necessitate substantial resources and precise interventions to enhance overall outcomes.