Fibula allograft

  • 文章类型: Journal Article
    大约20%的肱骨近端骨折(PHFs)不稳定和/或明显移位,因此需要手术。解剖复位后的锁定钢板固定已成为活跃人群中这些骨折的当前选择。然而,研究显示并发症发生率高达36%,如减少和血管坏死的损失。迄今为止,来自文献的数据对PHF中使用髓内腓骨同种异体移植物后的结果尚无定论,可能是由于案件的混合。假设在内侧铰链明显移位且不稳定的情况下,使用同种异体腓骨移植物有利于防止骨折的二次移位。导致更好的临床和患者报告的结果。
    在这项多中心配对队列研究中,不稳定的患者,位移PHF,包括解剖颈部骨折和明显移位的外科颈部骨折,包括在内。接受同种异体腓骨移植增强锁定板治疗的患者与没有同种异体移植的锁定板重建患者相匹配。比赛是根据骨折特征进行的,年龄,和性能状态。功能成果,患者报告的结果指标,并发症,和射线照相结果进行了比较。
    包括12例同种异体腓骨移植增强的骨合成患者,并与12例对照患者相匹配。同种异体腓骨移植组的平均年龄为58岁,而对照组为62岁。最短随访时间为12个月。臂肩和手的残疾评分,恒定肩关节评分,绑架,同种异体腓骨移植组和外旋转明显更好(17.4±8.6vs.26.1±19.2,P=.048;16.5±11.5vs.19.8±16.5P=.040;平均127°±38°vs.平均92°±49°P=-.045;50°±21°vs.平均26°±23°,P=.004)。两组之间的牛津肩评分无统计学差异(P=.105)。视觉模拟量表在组间没有显着差异(3.1±1.8vs.1.6±1.9,P=.439)。腓骨同种异体移植组的11例患者达到了影像学愈合,而对照组为8例(P=.317)。并发症发生率是对照组的两倍(3vs.7).
    在不稳定的PHF中,内侧铰链的额外支撑与同种异体腓骨移植相结合,似乎可以产生更稳定的结构,而不会损害头部关节表面的生存能力。因此,在选定的复杂病例中使用同种异体腓骨移植物可以获得更好的临床结果,并发症发生率较低。
    UNASSIGNED: About 20% of proximal humerus fractures (PHFs) are unstable and/or markedly displaced and therefore require surgery. Locking plate fixation after anatomical reduction has become the current treatment of choice for these fractures in the active population. However, studies have shown complication rates up to 36%, such as loss of reduction and avascular necrosis. To date, data from literature are inconclusive on outcomes following the use of an intramedullary fibula allograft in PHFs, possibly due to the case mix. It is hypothesized that the use of a fibula allograft is beneficial to prevent secondary displacement of the fracture in cases where the medial hinge is markedly displaced and unstable, resulting in better clinical and patient reported outcomes.
    UNASSIGNED: In this multicenter matched cohort study, patients with an unstable, displaced PHF, including anatomic neck fractures and significantly displaced surgical neck fractures, were included. Patients that were treated with a locking plate augmented with a fibula allograft were matched to patients who had undergone locking plate reconstruction without the allograft. The matches were made based on fracture characteristics, age, and performance status. Functional outcomes, Patient Reported Outcome Measures, complications, and radiographic results were compared.
    UNASSIGNED: Twelve patients with fibula allograft augmented osteosyntheses were included and matched to 12 control patients. The mean age was 58 years in the fibula allograft group compared to 62 years in the control group. Minimum follow-up was 12 months. Disability of the Arm Shoulder and Hand score, Constant Shoulder score, abduction, and external rotation were significantly better in the fibula allograft group (17.4 ± 8.6 vs. 26.1 ± 19.2, P = .048; 16.5 ± 11.5 vs. 19.8 ± 16.5 P = .040; mean 127° ± 38° vs. mean 92° ± 49° P = -.045; 50° ± 21° vs. mean 26° ± 23°, P = .004). There was no statistically significant difference in the Oxford Shoulder score between groups (P = .105). The Visual Analog Scale was not significantly different between groups (3.1 ± 1.8 vs. 1.6 ± 1.9, P = .439). Radiographic union was reached in 11 patients of the fibula allograft group compared to 8 in the control group (P = .317). The complication rate was twice as high in the control group (3 vs. 7).
    UNASSIGNED: Additional support of the medial hinge in unstable PHFs with a locking plate in combination with a fibula allograft appears to create a more stable construct without compromising the viability of the articular surface of the head. The use of a fibula allograft in selected complex cases could therefore result in better clinical outcomes with lower complication rates.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Randomized Controlled Trial
    背景:尽管是股骨头坏死(ONFH)的有效治疗方法,腓骨同种异体移植(HPS和FA)的髋关节保留手术仍有许多失败。开发基于临床和放射组学预测因子的预测模型有望解决此问题。
    方法:本研究包括112例接受HPS和FA的ONFH患者,随机分为训练和验证组。收集临床数据,使用单变量和多变量分析确定临床显著预测因子,以建立临床预测模型(CPM).同时,采用最小绝对收缩和选择算子方法从术前髋关节计算机断层扫描图像中选择最佳的影像组学特征,形成影像组学预测模型(RPM)。此外,为了提高预测精度,通过整合所有预测因子构建临床-影像组学预测模型(CRPM).使用受试者工作特征曲线(ROC)评估模型的预测性能,曲线下面积(AUC),DeLong测试,校正曲线,和决策曲线分析。
    结果:年龄,日本调查委员会分类,术后使用糖皮质激素或酒精,和非负重时间被确定为临床预测因子。CPM的ROC曲线的AUC在训练队列中为0.847,在验证队列中为0.762。整合影像组学功能后,CRPM显示训练队列的AUC值改善,为0.875,验证队列为0.918.决策曲线表明,在大多数风险阈值中,CRPM产生了更大的医疗效益。
    结论:CRPM可作为评估HPS和FA疗效的有效预测模型,并具有作为提高HPS和FA成功率的个性化围手术期干预工具的潜力。
    BACKGROUND: Despite being an effective treatment for osteonecrosis of the femoral head (ONFH), hip preservation surgery with fibula allograft (HPS&FA) still experiences numerous failures. Developing a prediction model based on clinical and radiomics predictors holds promise for addressing this issue.
    METHODS: This study included 112 ONFH patients who underwent HPS&FA and were randomly divided into training and validation cohorts. Clinical data were collected, and clinically significant predictors were identified using univariate and multivariate analyses to develop a clinical prediction model (CPM). Simultaneously, the least absolute shrinkage and selection operator method was employed to select optimal radiomics features from preoperative hip computed tomography images, forming a radiomics prediction model (RPM). Furthermore, to enhance prediction accuracy, a clinical-radiomics prediction model (CRPM) was constructed by integrating all predictors. The predictive performance of the models was evaluated using receiver operating characteristic curve (ROC), area under the curve (AUC), DeLong test, calibration curve, and decision curve analysis.
    RESULTS: Age, Japanese Investigation Committee classification, postoperative use of glucocorticoids or alcohol, and non-weightbearing time were identified as clinical predictors. The AUC of the ROC curve for the CPM was 0.847 in the training cohort and 0.762 in the validation cohort. After incorporating radiomics features, the CRPM showed improved AUC values of 0.875 in the training cohort and 0.918 in the validation cohort. Decision curves demonstrated that the CRPM yielded greater medical benefit across most risk thresholds.
    CONCLUSIONS: The CRPM serves as an efficient prediction model for assessing HPS&FA efficacy and holds potential as a personalized perioperative intervention tool to enhance HPS&FA success rates.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    UNASSIGNED: A traumatically shattered lumbosacral junction/pelvis may be difficult to repair. Here the authors offer a pelvic fixation technique utilizing routine pedicle screws, interbody lumbar fusions, bilateral iliac screws/ rods/crosslinks, and bilateral fibular strut allografts from the lumbar spine to the sacrum.
    UNASSIGNED: A middle aged male sustained a multiple storey fall resulting in a left sacral fracture, and right sacroiliac joint (SI) dislocation. The patient had previously undergone attempted decompressions with routine pedicle screw L4-S1 fusions at outside institutions; these failed twice. When the patient was finally seen, he exhibited, on CT reconstructed images, MR, and X-rays, a left sacral fracture nonunion, and a right sacroiliac joint dislocation.
    UNASSIGNED: The patient underwent a bilateral pelvic reconstruction utilizing right L4, L5, S1 and left L4, L5 pedicle screws plus interbody fusions (L4-L5, and L5, S1), performed from the left. Unique to this fusion construct was the placement of bilateral double iliac screws plus the application of bilateral fibula allografts from L4-sacrum filled with bone morphogenetic protein (BMP). After rod/screw/connectors were applied, bone graft was placed over the fusion construct, including the decorticated edges of the left sacral fractures, and right SI joint dislocation. We additionally reviewed other pelvic fusion reconstruction methods.
    UNASSIGNED: Here, we utilized a unique pelvic reconstruction technique utilizing pedicle screws/rods, double iliac screws/rods, and bilateral fibula strut grafts extending from the L4-sacrum filled with BMP.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    BACKGROUND: Osteonecrosis of the femoral head (ONFH) causes severe hip dysfunction. Left untreated, 80% of patients experience femoral head collapse, and 65-70% of patients require total hip arthroplasty (THA). Therefore, effective treatment is very important for ONFH.
    OBJECTIVE: To examine the effectiveness of fibula allografting for the treatment of early-stage ONFH METHODS: A systematic review was conducted by searching PubMed, EMBASE, and Web of Science databases using \"avascular necrosis\" or \"ischemic necrosis\" or \"osteonecrosis\" and \"femoral head\" and \"fibula*,\" and checking the references of primary articles and reviews. Two independent authors completed the study selection separately. We extracted the following details from each article: characteristics of the patients, clinical efficacy evaluation (Harris hip score [HSS], radiographic outcomes, the rate of conversation to total hip arthroplasty [THA], and adverse effects).
    RESULTS: A total of 213 articles were selected from PubMed (n = 45), EMBASE (n = 77), Web of Science (n = 203), and other sources (n = 10). After checking the articles, five articles were included in the final analysis. The average age of patients involved in this review was 34.48 years. The studies investigated fibula allografts to treat ONFH in 394 hips with a mean follow-up of 49.06 months. HHS was improved from 62.73 to 86.94. Radiographic progression was found in 33.66% of hips. The failure rate of head-saving surgery by THA was 14.5%. No patients had serious postoperative complications.
    CONCLUSIONS: The number of articles included in the study was small, and all studies were single-center studies. Most studies were retrospective with a low level of evidence. Surgical procedures were not identical with different follow-up times.
    CONCLUSIONS: Although there are some limitations to our approach, this systematic review supports fibula allografting as a simple, effective treatment for early-stage ONFH, which presents less postoperative complications, and has a satisfactory clinical effect. We consider it to be worthy of promotion as a therapy for ONFH.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Sci-hub)

       PDF(Pubmed)

  • 文章类型: Journal Article
    Although the use of fibular strut allografts in proximal humerus fractures has gained popularity, their use in other types of fractures is less well described. Fibular allografts have recently been used in the repair of complex periarticular fractures of the proximal tibia and distal femur. Fibular allografts can be inserted in a variety of manners to achieve goals specific to each individual fracture pattern. In the proximal tibia, insertion through a fracture line or cortical window facilitates joint surface elevation, prevents subsidence and enhances overall construct stability. In distal femoral fractures, including complex periarticular fractures, insertion through the fracture or cortical window permits indirect reduction of the medial cortex and provides necessary medial column support. An additional option in distal femur fractures includes fibula insertion as an intramedullary nail, allowing enhanced fixation in short distal fracture segments. In all cases, the use of a fibular allograft augments poor bone stock and provides improved screw purchase and construct stability when combined with conventional plating methods. Here we present a series of cases at our institution illustrating an array of novel techniques utilizing endosteal fibular allografts in the fixation of complex periarticular fractures about the knee.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Sci-hub)

       PDF(Pubmed)

公众号