■梭形细胞病变包括大量的良性和恶性病变,具有相似的临床和影像学特征。它们重叠的组织病理学特征确保了诊断困境。
■当前的多中心研究旨在根据细胞形态学和综合免疫组织化学分析来描绘成纤维细胞和成肌纤维的口腔梭形细胞病变。
■实验研究是在MSRamaiah应用科学大学进行的,班加罗尔,全印度应用科学研究所,德里。
■综合组织学评分标准和免疫组织化学标记组(STAT6,CD31,CD34,S100,SMA,波形蛋白,pan-CK,HHF-35,Ki67,ALK,desmin,HMB-45,SATB2,ERG,EMA和CD99)首次同时用于纤维母细胞和肌纤维母细胞口腔梭形细胞病变。将获得的数据制成表格并进行研究。
■NA。结果:使用细胞学评分标准和免疫组织化学标记组,分析和表征的病例为纤维增生性纤维瘤,纤维肉瘤,平滑肌肉瘤,结节性筋膜炎,神经纤维瘤和上皮样炎性肌纤维母细胞肉瘤(EIMS)。
■需要升级诊断策略,以诊断梭形细胞病变。重点必须放在细胞形态学上,免疫组织化学(IHC)标记物组对于准确诊断成纤维细胞和成肌纤维的口腔梭形细胞病变至关重要。
UNASSIGNED: Spindle cell lesions comprise a vast plethora of benign and malignant lesions with similar clinical and radiographic features. Their overlapping histopathologic features ensure a diagnostic dilemma.
UNASSIGNED: The current multicentric study aims to delineate
fibroblastic and myofibroblastic oral spindle cell lesions based on cytomorphology and comprehensive immunohistochemical analysis.
UNASSIGNED: The experimental study was conducted at MS Ramaiah University of Applied Sciences, Bangalore, and All India Institute of Applied Sciences, Delhi.
UNASSIGNED: A comprehensive histological scoring criteria and panel of immunohistochemical makers (STAT6, CD31, CD34, S100, SMA, vimentin, pan-CK, HHF-35, Ki67, ALK, desmin, HMB-45, SATB2, ERG, EMA and CD99) were employed concurrently for the first time for
fibroblastic and myofibroblastic oral spindle cell lesions. The data obtained was tabulated and studied.
UNASSIGNED: NA. Results: Using cytological scoring criteria and panel of immunohistochemical makers, the cases analysed and characterized were desmoplastic fibroma, fibrosarcoma, leiomyosarcoma, nodular fasciitis, neurofibroma and epithelioid inflammatory myofibroblastic sarcoma (EIMS).
UNASSIGNED: The diagnostic strategies need to be upgraded for the diagnosis of spindle cell lesions. Emphasis must be placed on cytomorphology, an immunohistochemistry (IHC) panel of markers is imperative for the accurate diagnosis of
fibroblastic and myofibroblastic oral spindle cell lesions.