■家猫(Feliscatus)是最常见的宠物之一。全球,大约五分之一的成年人对猫的过敏原敏感。主要的猫过敏原是分泌球蛋白Feld1,其主要在唾液腺和皮脂腺中产生。鸡产生IgY抗体,在结构上与哺乳动物IgG相似。当鸡暴露于Feld1时,会产生抗Feld1特异性IgY(AFD1),并自然浓缩在蛋黄中。这项研究的目的是评估耐受性,对生长和食物消费的影响,以及小猫中含有AFD1的鸡蛋产品成分的潜在不利影响。
■这是一个盲人,对照研究。二十七(27)只八周大的小猫被随机分配到三个含有0ppmAFD1的喂养组(0组),8ppmAFD1(第1组),和16ppmAFD1(第2组)持续84天。在第42天和第84天进行兽医检查和血液检查,并且每周监测体重和身体状况评分(BCS)。
■在整个研究过程中,任何受试者均未出现营养缺乏或不良临床事件.在饮食中服用含有AFD1的鸡蛋产品成分(无论是在涂层中还是在涂层和上衣的组合中)对体重和食物消耗都没有显着影响,并且所有受试者在整个研究中保持健康的身体状况评分(BCS)。此外,平均临床化学和血液学参数无生物学显著差异.
■这项研究表明,饮食配方中含有高达16ppm的AFD1,包括在涂层和干小猫食物的上衣中,耐受性良好,促进了充分的增长,并没有表现出不良影响。
UNASSIGNED: The domestic cat (Felis catus) is one of the most common pets. Worldwide, approximately one in five adults are sensitive to cat allergens. The major cat allergen is the secretoglobulin Fel d 1, which is primarily produced in the salivary and sebaceous glands. Chickens produce IgY antibodies, which are similar in structure to mammalian IgG. When chickens are exposed to Fel d 1, anti-Fel d 1-specific IgY (AFD1) is produced and is naturally concentrated in egg yolk. The aim of this study was to evaluate the tolerability, effects on growth and food consumption, and potential adverse effects of a chicken egg product ingredient containing AFD1 in kittens.
UNASSIGNED: This was a blinded, controlled study. Twenty-seven (27) eight-week old kittens were randomly assigned to three feeding groups containing 0 ppm AFD1 (Group 0), 8 ppm AFD1 (Group 1), and 16 ppm AFD1 (Group 2) for 84 days. Veterinary exams and bloodwork were performed on Day 42 and Day 84, and body weight and body condition score (BCS) were monitored weekly.
UNASSIGNED: Throughout the study, there were no signs of nutritional deficiency or adverse clinical events in any of the subjects. Administration of a chicken egg product ingredient containing AFD1 in the diet (whether in coating or combination of coating and top dress) had no significant effect on body weight nor food consumption, and all subjects maintained a healthy Body Condition Score (BCS) throughout the study. Moreover, there were no biologically significant differences in the mean clinical chemistry and hematology parameters.
UNASSIGNED: This study demonstrated that a diet formulated to contain up to 16 ppm AFD1, included in the coating and the top-dress of dry kitten food, was well tolerated, promoted adequate growth, and exhibited no adverse effects.