Feet

  • 文章类型: Journal Article
    为了研究SSc患者的假设,与健康对照组相比,脚部和脚趾背侧之间的温度梯度(远侧-背侧差[DDD])为“更负”(脚趾更冷),在第一(大)脚趾上最大,并且脚和手的热成像异常的严重程度是相关的。
    使用连接到iPhone的热像仪捕获了40名SSc患者和20名健康对照者的每只手脚背部的热成像图像。沿着手指的DDDs(食指,中间,测量环和小)和脚趾(大脚趾和“其他”)。
    SSc患者的大脚趾比对照组冷的趋势不明显。患者的平均大脚趾DDD更阴性(右:-2.89°C,左:-2.91°C,平均:-2.90°C)比对照组(右:-2.36°C,左:-2.42°C,平均值:-2.39°C)(平均值P=0.37)。患者\'大脚趾比\'其他\'(较小)脚趾更冷(右:-2.58°C,左:-2.63°C),虽然不是很重要。在SSc患者中,手指和大脚趾温度梯度相关(r=0.406,ρ=0.01)。
    我们的研究结果表明,大脚趾是SSc患者中最冷的,手指最冷的患者往往脚趾最冷。手部严重的RP症状应提示足病评估和足部护理教育。手机热成像是评估数字脉管系统的便捷工具,但首先需要在具有纵向分量的大型研究中进行验证。
    UNASSIGNED: To investigate the hypotheses that in patients with SSc, the temperature gradient between the dorsum of the foot and toes (distal-dorsal difference [DDD]) is \'more negative\' (toes cooler) than in healthy controls, is greatest along the first (great) toe and that the severities of thermographic abnormalities in the feet and hands are correlated.
    UNASSIGNED: Thermographic images of the dorsum of each hand and foot were captured using a thermal camera attached to an iPhone in 40 patients with SSc and 20 healthy controls. DDDs along the fingers (index, middle, ring and little) and toes (great toe and \'others\') were measured.
    UNASSIGNED: There was a non-significant trend for the great toes to be colder in patients with SSc than in controls. The mean great toe DDD was more negative in patients (right: -2.89°C, left: -2.91°C, mean: -2.90°C) than in controls (right: -2.36°C, left: -2.42°C, mean: -2.39°C) (P = 0.37 for mean values). Patients\' great toes were colder than \'other\' (lesser) toes (right: -2.58°C, left: -2.63°C), although not significantly. In patients with SSc, finger and great toe temperature gradients were correlated (r = 0.406, ρ = 0.01).
    UNASSIGNED: Our findings suggest that the great toe is the coldest in patients with SSc and that patients with the coldest fingers tend to have the coldest toes. Severe RP symptoms in the hands should prompt podiatry assessment and foot care education. Mobile phone thermography is a convenient tool for assessing the digital vasculature but first requires validation in larger studies with a longitudinal component.
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  • 文章类型: Journal Article
    为了了解身体畸形等疾病,我们需要了解健康个体的感性,概念性的,和他们身体的情感表现。人们对这些代表在不同身体区域之间的差异知之甚少,例如,手,脚,和整个身体,尽管它们在感官和功能水平上存在差异。为了理解这一点,我们为这些身体区域制定了更多隐含和明确的身体满意度衡量标准。67名参与者(年龄M=30.66,SD=11.19)完成了一系列在线内隐联想测试(IAT)和每个身体区域(手/脚/全身)的身体图像满意度视觉模拟量表(BISVAS;显式)。结果显示,在手的内隐意识水平没有差异,脚和整个身体,虽然差异在更明确的意识水平上很明显,手的身体形象满意度得分高于全身,脚的得分略低于手。这些发现表明视觉注意力,关注程度归因于一个身体区,和厌恶的司机可能是影响体验的态度身体形象满意度的因素。
    To understand conditions such as body dysmorphic disorder, we need to understand healthy individuals\' perceptual, conceptual, and emotional representations of their bodies. Not much is known about the differences in these representations across body districts, for example, hands, feet, and whole-body, despite their differences at sensory and functional levels. To understand this, we developed more implicit and explicit measures of body satisfaction for these body districts. Sixty-seven participants (age M = 30.66, SD = 11.19) completed a series of online Implicit Association Tests (IAT) and a Body Image Satisfaction Visual Analogue Scale (BISVAS; explicit) for each body district (hands/feet/whole body). The results show no differences in the more implicit level of awareness in hands, feet and whole body, while differences are apparent at a more explicit level of awareness, with higher scores for body image satisfaction for the hands than the whole body and marginally significant lower scores for feet than hands. Those findings suggest that visual attention, level of concern attributed to a body district, and disgust drivers are possible factors affecting the experience of attitudinal body image satisfaction.
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  • 文章类型: Journal Article
    我们必须更好地了解无挡板篮球运动员的脚型分类,以开发性别和尺寸特定的鞋垫。对500名具有代表性的无挡板篮球运动员(n=251名男性;n=251名女性)的脚进行了三维扫描。使用经过验证的MATLAB代码自动从这些扫描中提取六种不同的足部测量值。然后我们使用两步聚类分析和卡方检验对足部类型进行分类,并确定性别对每个聚类的影响,分别。确定了五种脚类型(超长和宽,又长又宽,扁平,锥形和短而窄),性别显著影响足部类型分类。穿着较小鞋码的球员的脚通常是短而窄和锥形的,而穿着较大尺码的球员的脚往往会变得更加超长和超宽。这些结果突出表明,无挡板篮球运动员有各种各样的脚类型;制造商应该使用这些数据来开发未来的评分系统,以提高无挡板篮球特定鞋类的合身性和功能性。
    本研究旨在调查无挡板篮球运动员的脚型。结果表明,应使用五种主要的脚型来为将来的鞋跟设计和尺寸分级系统提供信息。这些发现对改善无挡板篮球鞋的合身性和功能性具有重要意义。尤其是对于男人。
    We must better understand the foot type classifications of netball players to develop sex and size-specific shoe lasts. Five hundred and two representative-level netball players (n = 251 male; n = 251 female) had their feet three-dimensionally scanned. A validated MATLAB code was used to extract six different foot measurements from these scans automatically. We then used a two-step cluster analysis and chi-squared tests to classify foot types and determine the effect of sex on each cluster, respectively. Five foot types were identified (Extra long-and-wide, Long-and-wide, Flat, Tapered and Short-and-narrow), with sex significantly affecting foot type classification. The feet of players wearing smaller shoe sizes were often Short-and-narrow and Tapered, whereas the feet of players wearing larger sizes tended to be more Extra long-and-wide and Long-and-wide. These results highlight that netball players have a wide variety of foot types; manufacturers should use these data to develop future grading systems to improve the fit and functionality of netball-specific footwear.
    This study aimed to investigate the foot types of netball players. The results demonstrated that five main foot types should be used to inform future shoe last designs and size grading systems. These findings have implications for improving the fit and functionality of netball shoes, particularly for men.
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  • 文章类型: Journal Article
    很大比例的无挡板篮球运动员遭受与脚相关的问题和疼痛,并且对当前的无挡板篮球专用鞋类不满意。为了提高无挡板篮球专用鞋的合身性和功能性,我们必须了解这些球员的脚的形状,并确定是否存在任何性别差异。对500名具有代表性的无挡板篮球运动员(n=251名男性;n=251名女性)的脚进行了三维扫描。然后,我们使用经过验证的MATLAB代码自动提取10个测量值,以表征每个参与者的脚型。使用具有Bonferroni调整的α水平的独立样本t检验来鉴定男性和女性之间绝对值的差异以及标准化为脚长和身材的差异。男性无挡板篮球运动员的脚的大小和形状与女性运动员的脚有很大不同。男性的绝对和标准化足部测量值明显大于女性,特别是在脚的球上,脚跟和脚背(p<0.001)。无挡板球鞋制造商应为每种性别和脚的尺寸开发独特的鞋带,并应为无挡板球手提供更广泛的鞋长和宽度范围。这些考虑将有助于优化鞋子的合身性和舒适性,反过来,减少与脚相关的问题和与不合适的鞋类相关的疼痛。
    A large proportion of netball players suffer foot-related problems and pain and are dissatisfied with current netball-specific footwear. To improve the fit and functionality of netball-specific shoes, we must understand the shape of these players\' feet and determine whether any sex differences exist. Five hundred and two representative-level netball players (n = 251 male; n = 251 female) had their feet three-dimensionally scanned. We then used a validated MATLAB code to automatically extract 10 measurements to characterise each participant\'s foot shape. Differences between men and women for the absolute values and those normalised to foot length and stature were identified using independent samples t-tests with a Bonferroni adjusted alpha level. The size and shape of male netball players\' feet differed significantly from their female counterparts. Males had significantly larger absolute and normalised foot measurements than females, notably at the ball of the foot, heel and instep (p < 0.001). Netball shoe manufacturers should develop unique lasts for each sex and foot size and should offer a more extensive range of shoe lengths and widths to netball players. Such considerations will help optimise shoe fit and comfort and, in turn, reduce foot-related problems and pain associated with ill-fitting footwear.
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  • 文章类型: Journal Article
    背景:手脚骨折在儿童中很常见,但目前缺乏相关的流行病学研究。目的研究儿童手足骨折和生长板损伤的流行病学特征,为其预防提供理论依据。诊断,和治疗。
    方法:回顾性分析2015年7月至2020年12月深圳市儿童医院住院的手足骨折患儿的临床资料。关于人口特征的数据,骨折部位,治疗方法,损伤的病因,并收集了伴随的伤害。儿童分为四个年龄组:婴儿,学龄前儿童,学童,和青少年。骨折部位被归类为一级(第一-第五个手指/脚趾,掌骨,meta骨,腕骨,和tar骨)和第二级(第一第五:近端指骨,中间方阵,远端指骨,掌骨,和meta骨)部位。分析各年龄组儿童骨折部位及损伤原因的变化趋势。
    结果:总体而言,包括1301名儿童(1561名骨折;835名男孩和466名女孩)。学龄前儿童骨折发生率最高(n=549,42.20%),第三指的远端指骨是最常见的部位(n=73,15.57%)。青少年骨折的数量最少(n=158,12.14%),最常见的骨折部位是第五指近指骨(n=45,29.61%)。在1561处骨折中,1143发生在手和418在脚。手部骨折中最常见和最不常见的一级骨折部位是第五(n=300,26.25%)和第一(n=138,12.07%)手指,分别。最常见和最不常见的一级足骨折位置是第一(n=83,19.86%)和第四(n=26,6.22%)脚趾,分别。最常见的一级和二级病因是生命相关损伤(n=1128,86.70%)和夹闭损伤(n=428,32.90%),分别。随着年龄的增长,运动损伤的发生率逐渐增高,占青少年比例最高(26.58%)。手和脚骨折有许多伴随的伤害,前三名是甲床伤(570例,36.52%),生长板损伤(296例,18.96%),远端骨折(167例,10.70%)。在296名生长板受伤中,246发生在手上,50发生在脚上。
    结论:与以往关于小儿手足骨折的流行病学研究相比,我们绘制了这些骨折的位置,包括近端,轴,远端,骨phy板损伤。我们分析了骨折部位和损伤病因随年龄的变化趋势。手和足骨折有许多伴随的损伤,需要在诊断和治疗期间注意。医生应针对不同年龄段的儿童制定事故防护措施,加强安全教育,减少意外伤害的发生。
    BACKGROUND: Fractures of hands and feet are common in children, but relevant epidemiological studies are currently lacking. We aim to study the epidemiological characteristics of hand and foot fractures and growth plate injuries in children and provide a theoretical basis for their prevention, diagnosis, and treatment.
    METHODS: We retrospectively analyzed the data of children with hand and foot fractures who were hospitalized at Shenzhen Children\'s Hospital between July 2015 and December 2020. Data on demographic characteristics, fracture site, treatment method, etiology of injury, and accompanying injuries were collected. The children were divided into four age groups: infants, preschool children, school children, and adolescents. The fracture sites were classified as first-level (the first-fifth finger/toe, metacarpal, metatarsal, carpal, and tarsal) and second-level (the first-fifth: proximal phalanx, middle phalanx, distal phalanx, metacarpal, and metatarsal) sites. The changing trends in fracture locations and injury causes among children in each age group were analyzed.
    RESULTS: Overall, 1301 children (1561 fractures; 835 boys and 466 girls) were included. The largest number of fractures occurred in preschool children (n = 549, 42.20%), with the distal phalanx of the third finger being the most common site (n = 73, 15.57%). The number of fractures in adolescents was the lowest (n = 158, 12.14%), and the most common fracture site was the proximal phalanx of the fifth finger (n = 45, 29.61%). Of the 1561 fractures, 1143 occurred in the hands and 418 in the feet. The most and least common first-level fracture sites among hand fractures were the fifth (n = 300, 26.25%) and first (n = 138, 12.07%) fingers, respectively. The most and least common first-level foot fracture locations were the first (n = 83, 19.86%) and fourth (n = 26, 6.22%) toes, respectively. The most common first-level and second level etiologies were life related injuries (n = 1128, 86.70%) and clipping injuries (n = 428, 32.90%), respectively. The incidence of sports injuries gradually increased with age, accounting for the highest proportion in adolescents (26.58%). Hand and foot fractures had many accompanying injuries, with the top three being nail bed injuries (570 cases, 36.52%), growth plate injuries (296 cases, 18.96%), and distal severed fracture (167 cases, 10.70%). Among the 296 growth plate injuries, 246 occurred on the hands and 50 on the feet.
    CONCLUSIONS: In contrast to previous epidemiological studies on pediatric hand and foot fractures, we mapped the locations of these fractures, including proximal, shaft, distal, and epiphyseal plate injuries. We analyzed the changing trends in fracture sites and injury etiologies with age. Hand and foot fractures have many accompanying injuries that require attention during diagnosis and treatment. Doctors should formulate accident protection measures for children of different ages, strengthen safety education, and reduce the occurrence of accidental injuries.
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  • 文章类型: Journal Article
    这里,我们提供一个完整的,已更新,和插图清单,以及全面的研究,从SimadelosHuesos(SH,Atapuerca,西班牙)与其他人类比较样本相比,既有现存的,也有化石。从tarsals估计的最小个体数(MNI)已确定为15,占SH样本中确定的29个牙科个体的51.7%。在SH古人类足样本中,与其他人类个体/种群相比,可以观察到原始或多态以及衍生或自态性状的唯一组合。SH人素和尼安德特人之间共有其他特征,这些特征可能代表该进化系的共有衍生或自形特征,并且大多数可能与鲁棒性有关(例如,距骨的矩形滑车,宽的calcanei,宽阔的冰川,和短的侧向楔形文字)。此外,我们在SHtarsal样本中观察到了一些专有的自形性状(例如,距骨的狭窄头部和短的中间楔形文字)。SH的一些独特特征甚至比尼安德特人更健壮(例如,距骨宽的外侧踝关节面,更多的预测连续塔利,和宽内侧楔形文字)。与其他解剖学颅后骨骼元素支持的SH样本相比,这些特征可能表明尼安德特人的tal骨的优雅程度略高。此外,关于体型(身高和体重)做出了一些古生物学推论,并在SH样本中提出了一些关联。总之,SHtarsi的形态证实了该种群与尼安德特人之间姐妹群体的进化关系,可能代表了类似于尼安德特人祖先的形态。
    Here, we provide a complete, updated, and illustrated inventory, as well as a comprehensive study, of the tarsals (rearfoot) recovered from the Middle Pleistocene site of Sima de los Huesos (SH, Atapuerca, Spain) in comparison to other Homo comparative samples, both extant and fossil. The minimum number of individuals (MNI) estimated from the tarsals has been established as 15, which represents 51.7% of the 29 dental individuals identified within the SH sample. Within the SH hominin foot sample, an exclusive combination of primitive or plesiomorphic and derived or autapomorphic traits can be observed when compared with other Homo individuals/populations. Other characters are shared among SH hominins and Neandertals that might represent shared derived or autapomorphic traits for this evolutionary line, and most are likely related to robusticity (e.g., rectangular-like trochlea of the talus, broad calcanei, broad naviculars, and short lateral cuneiforms). Additionally, we observed some exclusive autapomorphic traits in the SH tarsal sample (e.g., narrow head of the talus and short intermediate cuneiforms). A few exclusive traits in SH tarsal remains are even more robust than in Neandertals (e.g., broad lateral malleolar facet in talus, more projected sustentaculum tali, and broad medial cuneiform). These traits could suggest a slightly higher level of gracilization in the tarsal bones of Neandertals compared to the SH sample that is also supported by other anatomical postcranial skeleton elements. Additionally, some paleobiological inferences are made in relation to body size (stature and body mass) and some associations are proposed within the SH sample. In conclusion, the morphology of the SH tarsi confirms an evolutionary relationship of sister groups between this population and Neandertals, probably representing a morphotype similar to the Neandertal ancestors.
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  • 文章类型: Journal Article
    这项研究提供了一个完整的,更新和插图清单,以及全面的研究,从SimadelosHuesos(SH,Atapuerca,西班牙)与其他人类比较样本相比,既有现存的化石.这个最新的审查已经确定了17个人的最低数量(MNI),占SH样本中确定的29个牙科个体的58.6%。可以在SH人物足样本中识别出性状的专有或自异型组合。与早期的人类和其他现代人类相比,一些特征显得原始或多态。SH古人类和尼安德特人还有其他格律和形态特征,有时代表该进化系中共有的衍生特征,其中大部分可能与鲁棒性有关。此外,在SH样本中观察到一些独特的自异型特征:非常广泛的第一跖骨,与尼安德特人和现代人相比,长而宽的幻觉近端足指骨和可能非常坚固的外侧远端足指骨。在这些最后的特征中,SHmeta骨和踏板指骨比尼安德特人更坚固。它们在这里被称为“超尼安德特人”特征,这可能表明在这个进化线中有一个轻微的优雅过程,至少在他的脚趾上.最后,关于体型(身高和体重)做出了一些古生物学推论,并在SH样本中提出了一些关联。
    This study provides a complete, updated and illustrated inventory, as well as a comprehensive study, of the metatarsals and foot phalanges (forefoot) recovered from the Middle Pleistocene site of Sima de los Huesos (SH, Atapuerca, Spain) in comparison to other Homo comparative samples, both extant and fossils. This current updated review has established a minimum number of individuals (MNI) of 17, which represent 58.6% of the 29 dental individuals identified within the SH sample. An exclusive or autoapomorphic combination of traits can be recognized within the SH hominin foot sample. A few traits appear primitive or plesiomorphic when compared with earlier Homo individuals and other recent modern humans. There are other metrical and morphological traits that SH hominins and Neandertals have in common that sometimes represent shared derived traits in this evolutionary line, most of which are probably related to robusticity. Furthermore, some exclusive autoapomorphic traits are observed in the SH sample: a very broad first metatarsal, long and broad hallucal proximal foot phalanges and possibly extremely robust lateral distal foot phalanges compared to those of Neandertals and modern humans. In these last traits, the SH metatarsals and pedal phalanges are even more robust than in Neandertals. They are herein named as \"hyper-Neandertal\" traits, which could suggest a slight gracilization process in this evolutionary line, at least in the hallux toe. Finally, some paleobiological inferences are made in relation to body size (stature and body mass) and some associations are proposed within the SH sample.
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  • 文章类型: Journal Article
    鞋类时尚是影响躯体人群健康的社会形成态度的一个例子。高跟鞋,特别是尖趾的鞋子会造成结构扭曲和脚过载,导致肌肉骨骼后遗症。在这里,我们编辑了多语言网站图像,展示了顶级制造商生产的女性鞋类,以评估女性穿着高跟鞋的普遍高度的广告效果。该方法基于使用InternetGoogle浏览器的多种语言中的命令“womanshoes”对网站的分析。然后,我们将互联网搜索的结果与波兰华沙市中心的100名成年女性所穿鞋类的街头实时监视结果进行了比较。我们发现,在代表西方文化领域国家的图像中,带有尖头鞋尖的细高跟鞋占主导地位,而较不富裕的世界地区则占主导地位。然而,我们注意到,在过去的十年里,高跟鞋的时尚逐渐偏离,现场街道监控证实,容易反映顶级鞋制造商网站介绍的变化,这与人们对高跟鞋潜在危害的认识不断提高相一致。然而,女性穿着更多生理鞋模的能力似乎超过了营销活动所带来的能力。取消高跟尖头鞋需要加强公共卫生领域的健康预防措施。
    Footwear fashion is an instance of a socially formed attitude affecting somatic population health. High-heeled, particularly pointy-toed shoes are posed to structurally distort and overload feet leading to musculoskeletal sequelae. Here we compiled multilanguage website images presenting female footwear produced by the top manufacturers to assess the advertising effects on the prevailing height of heels worn by women. The method was based on the analysis of websites using the command \"woman shoes\" in scores of languages of the Internet Google browser. We then compared the results of the internet search with those of a live street surveillance of the footwear worn by 100 adult women in the downtown Warsaw metropolis in Poland. We found that stiletto heels with pointed shoe tips significantly predominated in images representing the countries belonging to the Western cultural sphere compared to less affluent world areas where low or flat heels prevailed. However, we noted a gradual departure from the fashion of high heels over the last decade, confirmed by live street surveillance, liable to reflect changes in the website presentations of top shoe manufacturers consistent with increasing awareness of potential harm by high heels. Yet the female aptitude for wearing more physiologic shoe models appears to exceed that resulting from marketing campaigns. Doing away with high-heeled pointy-toed shoes requires intensification of pro-health preventive measures in the field of public health.
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  • 文章类型: Journal Article
    背景:足底足跟疼痛(PHP)患者的脚和踝肌功能降低,强度和尺寸,经常通过肌肉强化练习来治疗。然而,关于使用什么练习的调查很少,也没有可靠的证据基础来指导实践。这项研究旨在为PHP开发一个共识驱动的渐进式肌肉强化计划。
    方法:38位专家应邀参加了三轮研究。第1轮是一个开放式问卷,提供了为三种不同的PHP成人患者类型设计的渐进式强化计划的核心特征(年轻运动,超重的中年人,较老),作为小插图呈现。在第二轮中,专家表示同意拟议的演习和培训变量。在第三轮中,根据第二轮的答复,向专家们提出了对演习的修正,并表示他们同意这些变化。当超过70%的专家同意时,达成了共识。
    结果:两名专家不合格,12名专家拒绝,剩下24名(67%)参加第一轮的人。18(75%)完成了所有三轮比赛。从第一轮开始,为三个小插曲制定了逐步加强计划,其中包括10个不同的练习和三个训练变量(集合/重复,体重,和频率)。在第2轮中,68%(n=17)的练习和96%(n=72)的训练变量达成共识。在第3轮中,仅提出了练习更改,并且100%的练习达成了共识。
    结论:本研究提供了专家同意的三种渐进式强化计划,可用于未来的临床试验,以确定PHP肌肉强化的有效性。此外,临床医生可以将这些计划作为康复策略的一部分,但需要注意的是,随着更多研究的进行,这些计划可能会发生变化。
    BACKGROUND: People with plantar heel pain (PHP) have reduced foot and ankle muscle function, strength and size, which is frequently treated by muscle strengthening exercises. However, there has been little investigation of what exercises are used and there is no sound evidence base to guide practice. This study aimed to develop a consensus-driven progressive muscle strengthening program for PHP.
    METHODS: Thirty-eight experts were invited to participate in the study over three rounds. Round 1 was an open-ended questionnaire that provided the core characteristics of progressive strengthening programs designed for three different adult patient types with PHP (younger athletic, overweight middle-aged, older), which were presented as vignettes. In Round 2, experts indicated their agreement to the proposed exercises and training variables. In Round 3, experts were presented with amendments to the exercises based on responses from Round 2 and indicated their agreement to those changes. Consensus was achieved when > 70% of experts agreed.
    RESULTS: Two experts were ineligible and 12 declined, leaving 24 (67%) who participated in Round 1. Eighteen (75%) completed all three rounds. From Round 1, progressive strengthening programs were developed for the three vignettes, which included 10 different exercises and three training variables (sets / repetitions, weight, and frequency). In Round 2, 68% (n = 17) of exercises and 96% (n = 72) of training variables reached consensus. In Round 3, only exercise changes were presented and 100% of exercises reached consensus.
    CONCLUSIONS: This study provides three progressive strengthening programs agreed to by experts that can be used in future clinical trials to determine the effectiveness of muscle strengthening for PHP. In addition, clinicians could use the programs as part of a rehabilitation strategy with the caveat that they may change as more research is conducted.
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  • 文章类型: Journal Article
    处方强度(8%)辣椒素局部系统是美国FDA批准的用于足部疼痛性糖尿病周围神经病变的治疗方法。辣椒素8%局部系统的30分钟应用可以通过脱敏和减少表达TRPV1的皮肤纤维来提供持续(长达3个月)的局部疼痛缓解。辣椒素不被全身吸收;尽管相关的应用部位不适,辣椒素8%外用系统耐受性良好,没有已知的药物相互作用或禁忌症,并且可以提供优于口服选择的临床优势。辣椒素8%外用系统不适用于患者自我给药,需要纳入办公室程序,具有治疗依从性的额外好处。本文回顾了现有的文献,并提供了全面的,有关将辣椒素8%外用系统集成到办公程序中的实用信息。
    辣椒素8%外用系统用于治疗足部的糖尿病性神经痛。这种在办公室30分钟的应用可以通过靶向糖尿病受损的神经来提供持久的疼痛缓解(长达3个月)。由于辣椒素作用于糖尿病神经痛的部位而不被血液吸收,它不太可能干扰其他治疗,并且几乎没有不良影响。应用部位的不适是最常见的不良事件。辣椒素8%的局部系统必须由医疗保健专业人员使用,每个治疗最多可以使用四个局部系统。将8%辣椒素局部系统的使用纳入办公室程序可以帮助缓解患有糖尿病性足部神经疼痛的患者,并可以提高治疗依从性。
    Prescription-strength (8%) capsaicin topical system is a US FDA-approved treatment for painful diabetic peripheral neuropathy of the feet. A 30 min application of the capsaicin 8% topical system can provide sustained (up to 3 months) local pain relief by desensitizing and reducing TRPV1-expressing cutaneous fibers. Capsaicin is not absorbed systemically; despite associated application-site discomfort, capsaicin 8% topical system is well tolerated, with no known drug interactions or contraindications, and could offer clinical advantages over oral options. Capsaicin 8% topical system are not for patient self-administration and require incorporation into office procedures, with the added benefit of treatment compliance. This article reviews existing literature and provides comprehensive, practical information regarding the integration of capsaicin 8% topical systems into office procedures.
    Capsaicin 8% topical system is used to treat diabetic nerve pain of the feet. This in-office 30 min application can provide lasting relief of pain (for up to 3 months) by targeting the nerves damaged by diabetes. Since capsaicin acts at the site of diabetic nerve pain without being absorbed into the bloodstream, it is unlikely to interfere with other treatments and has few undesirable effects. Discomfort at the application site is the most commonly reported adverse event. Capsaicin 8% topical system must be applied by a healthcare professional and up to four topical systems can be used per treatment. Incorporating the use of capsaicin 8% topical systems into office procedures can help provide relief for patients living with diabetic nerve pain of the feet and may improve treatment compliance.
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