■足底筋膜炎是一种痛性肌腱病(肌腱病),在运动员中患病率很高。虽然健康的肌腱血流有限,超声显示肌腱病的血流量升高,但目前尚不清楚这是否与肌腱脉管系统事实上的增加有关。同样,在肌腱病中观察到糖胺聚糖(GAG)的积累,但它与临床疼痛的关系尚不清楚。
■为了探索血管化的程度,炎症,足底筋膜炎患者存在脂肪浸润,是否与临床症状有关。
■描述性实验室研究。
■在22例患者中,从肌腱疼痛和组织肿胀的原发部位(“近端”)以及在1至2厘米处宏观健康的区域(“远端”)获得了来自肌腱病理性足底筋膜组织的活检标本。活检标本用免疫荧光检查血管标记物,组织细胞密度,脂肪浸润,和巨噬细胞水平。此外,早晨第一步的疼痛(在早期研究中记录)与组织中胶原蛋白和GAG的含量相关.
■在近端(0.89%)和远端(0.96%)足底筋膜样本中均存在高血管化(和细胞性),而不一致但没有显著差异的脂肪浸润和巨噬细胞水平观察。2个足底筋膜区的胶原含量相似,而近端区域的GAG含量较高(近端为3.2%,远端为2.8%;P=.027).肌腱病患者(n=17),近端区域的GAG含量与主观晨痛评分呈正相关。
■在足底筋膜炎患者中,在疼痛的病灶区域和邻近的无症状区域均存在明显的组织血管形成.相比之下,有症状区域亲水性GAG的积累更多,并且与日常生活中临床疼痛水平的增加呈正相关.
GAG在组织中的积累而不是血管形成的程度似乎与疾病的疼痛症状的临床程度有关。
UNASSIGNED: Plantar fasciitis is a painful tendinous condition (tendinopathy) with a high prevalence in athletes. While a healthy tendon has limited blood flow, ultrasound has indicated elevated blood flow in tendinopathy, but it is unknown if this is related to a de facto increase in the tendon vasculature. Likewise, an accumulation of glycosaminoglycans (GAGs) is observed in tendinopathy, but its relationship to clinical pain is unknown.
UNASSIGNED: To explore to what extent vascularization, inflammation, and fat infiltration were present in patients with plantar fasciitis and if they were related to clinical symptoms.
UNASSIGNED: Descriptive laboratory study.
UNASSIGNED: Biopsy specimens from tendinopathic plantar fascia tissue were obtained per-operatively from both the primary site of tendon pain and tissue swelling (\"proximal\") and a region that appeared macroscopically healthy at 1 to 2 cm away from the primary site (\"distal\") in 22 patients. Biopsy specimens were examined with immunofluorescence for markers of blood vessels, tissue cell density, fat infiltration, and macrophage level. In addition, pain during the first step in the morning (registered during an earlier study) was correlated with the content of collagen and GAGs in tissue.
UNASSIGNED: High vascularization (and cellularity) was present in both the proximal (0.89%) and the distal (0.96%) plantar fascia samples, whereas inconsistent but not significantly different fat infiltration and macrophage levels were observed. The collagen content was similar in the 2 plantar fascia regions, whereas the GAG content was higher in the proximal region (3.2% in proximal and 2.8% in distal; P = .027). The GAG content in the proximal region was positively correlated with the subjective morning pain score in the patients with tendinopathy (n = 17).
UNASSIGNED: In patients with plantar fasciitis, marked tissue vascularization was present in both the painful focal region and a neighboring nonsymptomatic area. In contrast, the accumulation of hydrophilic GAGs was greater in the symptomatic region and was positively correlated with increased clinical pain levels in daily life.
UNASSIGNED: The accumulation of GAGs in tissue rather than the extent of vascularization appears to be linked with the clinical degree of pain symptoms of the disease.