背景:抗抑郁药可用于不同抑郁症和焦虑症的药物治疗,以及在其他适应症中可能有用。该研究的目的是确定在哥伦比亚卫生系统注册的18岁以上患者中使用抗抑郁药的适应症。
方法:回顾性研究数据来自18岁以上的患者,无论性别,在哥伦比亚卫生系统注册,谁是处方抗抑郁药。检查了医疗记录,寻找经监管机构批准和未经批准的适应症。患者被随机识别,以及社会人口统计学,可能与未经批准的适应症处方相关的临床和药理学变量。
结果:对351例患者进行了评估,平均年龄为60.4±15.3岁,其中72.6%是女性。他们参加了34个城市,处方主要由全科医生开(n=276;78.6%),和精神科医生(n=42;12.0%)。选择性5-羟色胺再摄取抑制剂是最广泛使用的抗抑郁药(n=204;58.1%),其次是非典型(n=76;21.7%)。最常见的适应症是抑郁症(n=169;48.1%),焦虑(n=48;13.7%),疼痛(n=22;6.3%)和睡眠障碍(n=17;4.8%)。共开出188份(53.6%)用于批准适应症的处方,其余163人(46.4%)被列为未获批准。
结论:抗抑郁药用于治疗抑郁症,焦虑,疼痛和睡眠障碍,尤其是老年女性,但几乎一半的制剂用于未经批准的适应症。
BACKGROUND: Antidepressants are useful in the pharmacological treatment of different depressive and anxiety disorders, as well as being potentially useful in other indications. The aim of the study was to determine the indications for which antidepressants are being prescribed in patients over 18 years of age registered with the Colombian Health System.
METHODS: Retrospective study with data from patients over 18 years old, of either sex, registered with the Colombian Health System, who are prescribed antidepressants. Medical records were reviewed, looking for indications approved and not approved by regulatory agencies. Patients were identified randomly, as well as the sociodemographic, clinical and pharmacological variables that could be associated with prescriptions for unapproved indications.
RESULTS: 351 patients were evaluated, with a mean age of 60.4 ± 15.3 years, of whom 72.6% were women. They were attended in 34 cities, with prescriptions mainly by general practitioners (n = 276; 78.6%), and psychiatrists (n = 42; 12.0%). Selective serotonin reuptake inhibitors were the most widely prescribed antidepressants (n = 204; 58.1%), followed by atypicals (n = 76; 21.7%). The most frequent indications were for depression (n = 169; 48.1%), anxiety (n = 48; 13.7%), pain (n = 22; 6.3%) and sleep disorders (n = 17; 4.8%). A total of 188 prescriptions (53.6%) were made for approved indications, and the remaining 163 (46.4%) were classified as unapproved.
CONCLUSIONS: Antidepressants are being prescribed for the treatment of depression, anxiety, pain and sleep disorders, especially in older adult women, but almost half of the formulations were for unapproved indications.