UNASSIGNED:比较儿童和青少年甲状腺乳头状癌(PTC)的超声和病理特征。
UNASSIGNED:本研究纳入了2017年至2022年间手术诊断为儿童或青少年PTC的53例患者。术前超声检查,术后组织学,并对其分子及临床特点进行回顾性分析。
未经评估:在组成上没有观察到差异,回声,用超声检查成形。此外,有明显更高的甲状腺外延伸率,点状回声灶,与青少年相比,儿童的淋巴结转移。分子分析表明,BRAFV600E突变是青少年PTC中最普遍的异常(12/20,60.0%)。然而,他们在儿童PTC中较少(7/23,30.4%)。此外,使用下一代测序,3例致癌融合(1例TRIM33-RET,一个CCDC6-RET案例,和1例STRN-ALK病例)在儿童PTC中发现。
未经证实:甲状腺外延伸的频率,点状回声灶,儿童PTC的淋巴结转移较高,而BRAFV600E突变在青少年PTC中更高。
UNASSIGNED: To compare the ultrasonography and pathology features between children and adolescents with papillary thyroid carcinoma (PTC).
UNASSIGNED: A total of 53 patients who were surgically diagnosed with childhood or adolescent PTC between 2017 and 2022 were included in this study. The pre-operative ultrasonography, post-operative histology, and molecular and clinical characteristics were retrospectively analyzed.
UNASSIGNED: No differences were observed in composition, echogenicity, and shape using ultrasonography. Moreover, there was a significantly higher rate of extrathyroidal extension, punctate echogenic foci, and lymph node metastases in children compared to adolescents. The molecular analysis showed that BRAFV600E mutations are the most prevalent abnormality in adolescent PTC (12/20, 60.0%). However, they are less in childhood PTC (7/23, 30.4%). In addition, using next-generation sequencing, three cases with oncogenic fusion (one TRIM33-RET case, one CCDC6-RET case, and one STRN-ALK case) were identified in childhood PTC.
UNASSIGNED: The frequency of extrathyroidal extension, punctate echogenic foci, and lymph node metastases were higher in childhood PTC, while BRAFV600E mutations were higher in adolescent PTC.