未经证实:内皮功能障碍与心血管疾病(CVD)风险增加相关。目前可用的测量内皮功能的非侵入性方法具有局限性。我们测试了一种新型设备,该设备可自动测量基线和缺血后之间的差异,充血诱导,肱动脉顺应性,一种已知的内皮依赖性现象。计算出的指数之间的关联,流量介导的依从性反应(FCR),并确定了建立的CVD风险指数。
UNASSIGNED:纳入有CVD危险因素或已知冠状动脉疾病(CAD)的成人。计算Framingham风险评分(FRS)并评估代谢综合征(MetSyn)的存在。超声发现颈动脉斑块。通过6分钟步行测试(6MWT)评估心肺适应性。使用该装置测量FCR。
未经评估:在135名参与者中,平均年龄49.3+/-17.9岁,特征包括:48%为女性,7%的吸烟者,7%CAD,10%2型糖尿病,34%的MetSyn,38%伴有颈动脉斑块。那些有MetSyn的FCR比没有的低24%(p<0.001)。较低的FCR与较高的FRS百分位数相关(r=-0.29,p<0.001),更多的MetSyn因子(r=-0.30,p<0.001),更多的颈动脉斑块(r=-0.22,p=0.01),和较低的6MWT(r=0.34,p<0.0001)。
未经批准:FCR,使用一种新颖的自动获得的动脉反应性指数,独立于操作员的设备,与已建立的CVD风险指数呈负相关,颈动脉斑块数量增加,和降低心肺健康。测量FCR是否可以在筛查CVD风险和评估内皮功能是否改变以降低CVD风险为目标的治疗中起作用。值得进一步研究。
UNASSIGNED: Endothelial dysfunction is associated with increased risk of cardiovascular disease (CVD). Currently available noninvasive methods of measuring endothelial function have limitations. We tested a novel device that provides an automated measurement of the difference between baseline and post-ischemic, hyperemia-induced, brachial arterial compliance, a phenomenon known to be endothelium-dependent. The association between the calculated index, Flow-mediated Compliance Response (FCR), and established CVD risk indices was determined.
UNASSIGNED: Adults with CVD risk factors or known coronary artery disease (CAD) were enrolled. Framingham Risk Score (FRS) was calculated and presence of metabolic syndrome (MetSyn) was assessed. Carotid artery plaques were identified by ultrasound. Cardiorespiratory fitness was assessed by 6-minute walk test (6MWT). FCR was measured using the device.
UNASSIGNED: Among 135 participants, mean age 49.3 +/- 17.9 years, characteristics included: 48% female, 7% smokers, 7% CAD, 10% type 2 diabetes, 34% MetSyn, and 38% with carotid plaque. Those with MetSyn had 24% lower FCR than those without (p < 0.001). Lower FCR was associated with higher FRS percentile (r = -0.29, p < 0.001), more MetSyn factors (r = -0.30, p < 0.001), more carotid plaques (r = -0.22, p = 0.01), and lower 6MWT (r = 0.34, p < 0.0001).
UNASSIGNED: FCR, an index of arterial reactivity obtained automatically using a novel, operator-independent device, was inversely associated with established CVD risk indices, increased number of carotid plaques, and lower cardiorespiratory fitness. Whether measuring FCR could play a role in screening for CVD risk and assessing whether endothelial function changes in response to treatments aimed at CVD risk reduction, warrants further study.