个体的自然昼夜节律支配24小时的睡眠-觉醒周期。这种内部循环的中断可能导致重大的健康危害和睡眠障碍。报告显示,全世界至少有50%的人患有与睡眠有关的疾病。屏幕时间的增加,特别是在COVID-19大流行之后,是这种情况的外部原因之一。虽然许多因素控制着生物钟及其异常,许多研究人员已将PER2基因与时间型密切相关.本论文对PER2基因内的关键单核苷酸多态性及其与四种主要类型睡眠障碍的潜在联系进行了广泛的研究。这项研究调查了这些SNP是否在睡眠障碍中起致病作用,或者它们是否仅与这些疾病有关。此外,我们探讨这些遗传变异是否会对这些睡眠模式产生终身影响,或者外部因素是否会导致睡眠障碍的发展。该基因是负责其他时钟基因转录的昼夜节律周期的关键调节因子。它调节多种生理系统,如新陈代谢,睡眠,体温,血压,内分泌,免疫学,心血管,和肾功能。我们的目标是明确这个基因的多面性,这经常被忽视,并寻求建立PER2基因突变在睡眠障碍中的机制作用。这将增进进一步的了解,评估,以及将来对这些疾病的治疗。
The natural circadian rhythm in an individual governs the sleep-wake cycle over 24 h. Disruptions in this internal cycle can lead to major health hazards and sleep disorders. Reports suggest that at least 50 % of people worldwide suffer from sleep-related disorders. An increase in screen time, especially in the wake of the COVID-19 pandemic, is one of the external causative factors for this condition. While many factors govern the circadian clock and its aberrance, the PER2 gene has been strongly linked to chronotypes by many researchers. The current paper provides an extensive examination of key Single Nucleotide Polymorphisms within the PER2 gene and their potential connection to four major types of sleep disorders. This study investigates whether these SNPs play a causative role in sleep disorders or if they are solely associated with these conditions. Additionally, we explore whether these genetic variations exert a lifelong influence on these sleep patterns or if external triggers contribute to the development of sleep disorders. This gene is a crucial regulator of the circadian cycle responsible for the transcription of other clock genes. It regulates a variety of physiological systems such as metabolism, sleep, body temperature, blood pressure, endocrine, immunological, cardiovascular, and renal function. We aim to establish some clarity to the multifaceted nature of this gene, which is often overlooked, and seek to establish the mechanistic role of PER2 gene mutations in sleep disorders. This will improve further understanding, assessment, and treatment of these conditions in future.