高场非对称离子迁移谱(FAIMS)是一种基于高电子场下离子迁移变化的离子分离和检测技术。虽然补偿电压扫描速度是FAIMS中的一个基本参数,其对光谱的影响尚不清楚。在这项工作中,引入了一个称为F-EMG的函数来描述补偿电压扫描速度对FAIMS光谱的影响,并研究了该函数的性质。理论分析强调了扫描速度对峰高的影响,position,和对称性,以及F-EMG函数在较低的扫描速度下逐步接近高斯函数的能力。此外,该函数表明,在正和负扫描模式下获得的光谱具有对称性。实验验证,使用自定义FAIMS设置和分析硫化氢进行,乙苯,甲苯,苯乙烯,苯和氨,确认模型对峰特征的影响,拟合精度,并且在较低的扫描速度下表现出与高斯函数更接近的对准。此外,实验数据表明,光谱在正负扫描模型中显示出对称性。这项工作不仅提高了对FAIMS频谱分析的理解,而且还引入了一种强大的方法,用于在不同的扫描速度下提高数据准确性。
High-Field Asymmetric Ion Mobility Spectrometry (
FAIMS) is a technique for ion separation and detection based on ion mobility variation under high electronic field. While compensation voltage scanning speed is a fundamental parameter in
FAIMS, its impact on spectra remains unclear. In this work, a function referred to as F-EMG is introduced to describe the impact of compensation voltage scanning speed on
FAIMS spectra, and the properties of the function are studied. Theoretical analysis emphasizes the impact of the scanning speed on peak height, position, and symmetry, as well as the capability of the F-EMG function to progressively approach Gaussian function at lower scanning speeds. Furthermore, the function indicates that spectra obtained in positive and negative scanning modes exhibits symmetry. An experimental validation, conducted with a custom
FAIMS setup and analyzing hydrogen sulfide, ethylbenzene, toluene, styrene, benzene and ammonia, confirms the model\'s influence on peak features, fitting accuracy, and exhibits a closer alignment with the Gaussian function at lower scanning speeds. Additionally, the experimental data indicate that the spectra show symmetry in positive and negative scanning models. This work not only improves understanding of
FAIMS spectral analysis but also introduces a robust method for enhancing data accuracy across varying scanning speeds.