Fístula arteriovenosa

动脉粥样硬化
  • 文章类型: Journal Article
    目的:充分的血液透析需要功能性和持久的血管通路。动静脉瘘优于人工移植物或中心静脉导管。但它与原发性失败和成熟失败的高比率有关。术前用彩色多普勒超声(CDU)绘制手臂血管有助于实现更好的短期和长期结果。不幸的是,比体格检查更耗时,并且需要经验丰富的检查者和特殊设备;一些作者认为CDU不应该成为常规术前评估的一部分。我们报告了我们使用彩色多普勒超声进行术前血管标测的经验,目的是为手术团队提供血管通路,血管通路的监测,和主要结果的评估(主要失败,成熟失败,和通畅性)。
    方法:这是一项单中心回顾性研究,包括在2019年1月至2021年12月期间参加特定预约血管通路计划咨询的患者。肾脏科医生进行了体格检查和血管标测,并向血管外科医生团队提出了血管通路的特定类型和位置。通过功能性血管通路对患者进行随访,直到第一次血液透析后一个月。
    结果:在这项研究中,评估了167例患者(114例事件患者-慢性肾脏病4或5期-和53例流行患者-通过中心静脉导管进行血液透析)。肾脏科医师建议的血管通路为70例(41.9%)的radial头动静脉瘘,50例患者(29.9%)的头臂动静脉瘘,34例(20.4%)患者的臂-贵重动静脉瘘,动静脉移植8例(4.8%),中心静脉导管2例(1.2%)。141例患者建立了血管通路:57例患者(40.4%)远端动静脉瘘,54例(38.3%)的肱-头动静脉瘘,27例患者(19.1%),动静脉移植3例(2.1%)。创建的访问对应于129名患者(91.5%)的建议访问。记录了22个(15.6%)主要故障。远端动静脉瘘和糖尿病与原发性衰竭的高风险相关(OR=3.929(1.485-10.392),p=0.004;OR=3.867(1.235-12.113),分别为p=0.014)。8周时成熟失败的发生率为4.8%。在6、12和24个月的主要通畅率为76.3%,70.4%和49.2%。初级辅助通畅率在6个月和12个月为84.8%,在24个月为81.3%。
    结论:这项研究表明,用彩色多普勒超声对整个血管区域进行研究,在一个由肾病学家和血管外科医生组成的多学科团队中,与高的自体进入率和极低的原发性失败和成熟失败率相关(在文献中几乎是前所未有的)。
    Functional and durable vascular access is needed for adequate hemodialysis. Arteriovenous fistula is preferred over prosthetic grafts or central venous catheters, but it is associated with high rates of primary failure and maturation failure. Preoperative mapping of arm vessels with color Doppler ultrasound (CDU) has been shown to be helpful in achieving better short and long-term outcomes. Unfortunately, is more time-consuming than a physical examination and requires an experienced examiner and special equipment; some authors defend that CDU should not be part of the routine preoperative assessment. We reported our experience in preoperative vessel mapping using color Doppler ultrasound to purpose a vascular access to the surgical team, surveillance of vascular access, and evaluation of main outcomes (primary failure, maturation failure, and patency).
    This is a single-center retrospective study that includes patients who attended a specific appointment for vascular access planning consultation between January 2019 and December 2021. A nephrologist performed the physical exam and vascular mapping and proposed to the vascular surgeon team a specific type and location of vascular access. Patients were followed until one month after the first hemodialysis through functioning vascular access.
    In this study, 167 patients were evaluated (114 incident patients - chronic kidney disease stage 4 or 5 - and 53 prevalent patients - under hemodialysis through central venous catheter). The vascular accesses proposed by nephrologist were radial-cephalic arteriovenous fistula in 70 patients (41.9%), brachio-cephalic arteriovenous fistula in 50 patients (29.9%), brachio-basilic arteriovenous fistula in 34 patients (20.4%), arteriovenous graft in 8 patients (4.8%) and central venous catheter in 2 patients (1.2%). Vascular access was constructed in 141 patients: distal arteriovenous fistula in 57 patients (40.4%), brachio-cephalic arteriovenous fistula in 54 patients (38.3%), brachio-basilic AVF in 27 patients (19.1%), and arteriovenous graft in 3 patients (2.1%). The created access corresponds to the proposed access in 129 patients (91.5%). Twenty-two (15.6%) primary failures were registered. Distal arteriovenous fistulas and diabetes mellitus were associated with a higher risk of primary failure (OR=3.929 (1.485-10.392), p=0.004; OR=3.867 (1.235-12.113), p=0.014, respectively). The incidence of maturation failure at eight weeks was 4.8%. The primary patency at 6, 12 and 24 months was 76.3%, 70.4% and 49.2%. Primary assisted patency was 84.8% at 6 and 12 months and 81.3% at 24 months.
    This study demonstrates that the study of the entire vascular territory performed with color Doppler ultrasound, within a multidisciplinary team of nephrologists and vascular surgeons, is associated with high rates of autologous access and very low rates of primary failure and maturation failure (almost unprecedented in the literature).
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  • 文章类型: Journal Article
    目的:患者激活是一个概念,指的是管理一个人的健康和医疗护理的意愿。为了评估它,已开发并验证了患者激活措施(PAM)。一些研究报告慢性疾病患者的低激活。然而,关于血液透析患者激活的信息很少.本研究的目的是描述在HD单元中进行慢性治疗的患者的激活水平及其与疾病控制参数的关系。
    方法:在慢性HD治疗的晚期慢性肾脏病患者中进行横断面观察研究。包括96名患者。用PAM-13问卷测量活化。它与描述性变量(年龄,性别,合并症,研究,栖息地)和疾病控制变量(血管通路,血流量,钾血症,磷酸盐血症,透析间增益)进行了研究。为此,斯皮尔曼相关性检验,采用多元线性回归模型和logistic模型作为统计方法。
    结果:平均(SD)PAM-13评分为63.19(15.21)。激活与血管通路显著相关(P=0.003),血流量(P=0.024),和患者的透析间增益(P=0.008)。
    结论:接受慢性血液透析治疗的患者的活化程度较低。较高的激活与动静脉瘘有关,更高的血流量和更低的透析间增益。需要进一步的研究来确认和应用我们的结果。
    Patient activation is a concept that refers to the willingness to manage one\'s health and medical care. To assess it, a patient activation measure (PAM) has been developed and validated. Several studies report low activation in patients with chronic diseases. However, information on activation in hemodialysis patients is scarce. The aim of the present study is to describe the activation level of patients on chronic treatment in an HD unit and its relationship with disease control parameters.
    Cross-sectional observational study in patients with advanced chronic kidney disease on chronic HD treatment. Ninety-six patients were included. Activation was measured with the PAM-13 questionnaire. Its relationship with descriptive variables (age, sex, comorbidity, studies, habitat) and disease control variables (vascular access, blood flow, potassaemia, phosphataemia, interdialytic gain) was studied. For this purpose, Spearman\'s correlation test, multiple linear regression model and logistic model were used as statistical methods.
    The mean (SD) PAM-13 score was 63.19 (15.21). Activation was significantly associated with vascular access (P = 0.003), blood flow (P = 0.024), and interdialytic gain of patients (P = 0.008).
    Activation in patients on chronic hemodialysis treatment is low. Higher activation is related having an arteriovenous fistula, higher blood flow and lower interdialytic gain. Future studies are needed to confirm and apply our results.
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  • 文章类型: Journal Article
    OBJECTIVE: The increased survival rates of end-stage renal disease (ESRD) patients have impacted directly in the proportion of elderly patients requiring a reliable hemodialysis (HD) access; this group clearly demands an individualized approach. We aim to analyze maturation and patency rates of arteriovenous fistulas (AVF) in elderly patients.
    METHODS: This was retrospective review of a database of patients that underwent AVF creation in our institution. The maturation and patency rates were analyzed divided in groups based on age (equal and greater of 65 years, and patients under 65 years). Patency rates were compared using Kaplan-Meier analysis.
    RESULTS: Twenty patients ≥ 65 years old (mean 73, SD ± 5.4) were analyzed. The overall maturation rate in this group was 75% compared to 84.1% (p = 0.33) in the younger group (mean age 48 years, SD ± 17). The primary patency at 6 and 12 months for the ≥ 65 years group was 93% and 86%, respectively, compared with 85% and 81% for the younger group (p = 0.77).
    CONCLUSIONS: Autogenous AVF remains the preferred and durable option for elderly patients. We found no difference in terms of maturation and patency rates compared to younger patients. Standardized protocols are needed to optimally select vascular accesses.
    BACKGROUND: El aumento de las tasas de supervivencia en los pacientes con enfermedad renal terminal ha impactado en los pacientes con acceso para hemodiálisis.
    OBJECTIVE: Analizar las tasas de maduración y permeabilidad de las fístulas arteriovenosas en pacientes adultos mayores.
    UNASSIGNED: Estudio retrospectivo en el que se incluyeron pacientes a los que se realizó fístula arteriovenosa. Las tasas de maduración y permeabilidad se analizaron divididas en grupos según la edad (≥ 65 y < 65 años). Las tasas de permeabilidad se compararon mediante análisis de Kaplan-Meier.
    RESULTS: Se analizaron 20 pacientes ≥ 65 años. La tasa de maduración global en este grupo fue del 75%, frente al 84.1% (p = 0.33) en el grupo más joven. La permeabilidad primaria a los 6 y 12 meses para el grupo ≥ 65 años fue del 93% y el 86%, respectivamente, en comparación con el 85% y el 81% en el grupo más joven (p = 0.77).
    CONCLUSIONS: La fístula arteriovenosa autógena sigue siendo la opción preferida y duradera para los pacientes de edad avanzada. No encontramos diferencias en cuanto a las tasas de maduración y permeabilidad en comparación con los pacientes más jóvenes.
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  • 文章类型: Journal Article
    目的:为了评估在止血过程中通过可调节止血钳对动静脉瘘(AVF)产生的压力,并将其与患者直接施加的两指压力进行比较。评估直接两指压力在止血过程中的变化。
    方法:我们分析了来自15例患者的51例血液透析程序的数据。AVF入路压力用作两种方法产生的压力的间接指标。在取出静脉针(PBasal)之前记录,在夹具应用(P1)时,在护士(P2)调整夹具后,在患者直接双指按压开始时(M0),在两指压力3分钟(M3)和两指压力6分钟(M6)后。
    结果:使用调整后的夹具(P2)的入路压力低于患者直接双指压力(M0)(变化-18.57%,95CI-14.09至-4.77mmHg,P<0.001)。直接两指压法产生的通路内压力沿止血过程呈下降趋势(M3-M0:-8.82mmHg,P<0.001;M6-M0:-12.55mmHg,P<0.001)。
    结论:可调节的瘘管臂钳在AVF中产生的压力低于患者直接施加的两指压力。后者在止血过程中呈下降趋势。这些数据表明,临床指南的一些建议可能基于不准确的前提。
    OBJECTIVE: To evaluate the pressure generated by an adjustable hemostasis clamp on arteriovenous fistulas (AVF) during the hemostasis proccess, and compare it with the direct two-finger pressure applied by the patient. To evaluate the variations of the direct two-finger pressure along the hemostasis process.
    METHODS: We analyzed data obtained in 51 hemodialysis procedures from 15 patients. AVF intraaccess pressure was used as indirect indicator of the pressure generated by both methods. It was recorded before venous needle removal (PBasal), at clamp application (P1), after clamp adjustement by a nurse (P2), at the beginning of the direct two-finger pressure by the patient (M0), after 3 min of two-finger pressure (M3) and after 6 min of two-finger pressure (M6).
    RESULTS: Intra-access pressure was lower with the adjusted clamp (P2) than with the direct two-finger pressure by the patient (M0) (variation of -18.57%, 95%CI -14.09 to -4.77 mmHg, P < 0.001). Intraaccess pressure generated by the direct two-finger pressure method showed a decreasing trend along the hemostasis process (M3-M0: -8.82 mmHg, P < 0.001; M6-M0: -12.55 mmHg, P < 0.001).
    CONCLUSIONS: An adjustable fistula arm clamp generates a lower pressure in AVF than the direct two-finger pressure applied by the patient. The latter showed a decreasing trend along the hemostasis process. These data suggest that some of the recommendations from clinical guidelines could be based on inaccurate premises.
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  • 文章类型: Journal Article
    在用于血液透析的血管通路(VA)手术之前,越来越多地使用双重超声(DUS)。然而,这种方法的成本效益是未知的。我们的目标是评估引入DUS评估的专业咨询是否会改变成本和时间延迟,以实现血液透析的第一个VA有效。
    经DUS(ECO组)专门会诊后接受首次VA(2014年6月至2017年7月)的前瞻性队列患者。将他们与历史队列(2012年1月至2014年5月)进行比较,其中VA仅通过临床评估(CLN组)表示。我们分析了与访问有关的费用,DUS评估,干预措施,至少在1个月内达到血液透析有效的第一个VA。
    CLN组86例,ECO组92例。ECO组的患者年龄较小(68.4vs.64.0年;P=.038),但组间无其他差异。在ECO组中,实现血液透析的第一个AV有效的平均成本显着降低(2707与3347欧元;P=.024)。ECO组的DUS评估费用较高,但CLN组的随访费用较高,连续的手术干预,假肢材料,住院天数和导尿管。在ECO组中,实现血液透析的首次AV有效所需的平均时间也较短(49.9vs.82.9天,P=.002)。
    在进行VA手术之前,通过DUS进行专门的血管通路咨询,降低了获得血液透析有效的第一个VA所需的成本。从患者的角度来看,这意味着更少的干预措施和住院时间以及缩短的时间延迟。
    Duplex ultrasound (DUS) is increasingly used before vascular access (VA) surgery for haemodialysis. However, the cost-effectiveness of this approach is unknown. Our objective was to assess whether the introduction of a specialised consultation with DUS assessment modifies the cost and the time delay to achieve a first VA valid for haemodialysis.
    Prospective cohort of patients undergoing a first VA (June 2014-July 2017) after a specialised consultation with DUS (ECO group). They were compared with a historical cohort (January 2012-May 2014) where VA was indicated exclusively by clinical evaluation (CLN group). We analysed the cost related to visits, DUS assessments, interventions, hospital admissions and graft materials to achieve a first VA valid for haemodialysis at least during 1 month.
    86 patients in the CLN group were compared with 92 in the ECO group. Patients in the ECO group were younger (68.4 vs. 64.0 years; P=.038) but no other differences were seen among groups. The average cost to achieve a first AV valid for haemodialysis was significantly lower in the ECO group (2707 vs. 3347€; P=.024). There was a higher cost associated with DUS assessments in the ECO group yet the CLN group had a higher cost related to follow-up visits, successive surgical interventions, prosthetic material, days of hospital admission and catheters. The mean time needed to achieve a first AV valid for haemodialysis was also shorter in the ECO group (49.9 vs. 82.9 days, P=.002).
    The introduction of a specialised vascular access consultation with DUS prior to VA surgery has reduced the cost necessary to achieve a first VA valid for haemodialysis. From the patient\'s point of view this has meant less interventions and hospital admissions and a shortening of the time delay.
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  • 文章类型: Journal Article
    慢性肾脏病(CKD)是一个新兴的全球负担,越来越多的患者需要肾脏替代治疗(RRT),血液透析是最普遍的透析方式。功能正常的血管通路仍然是适当治疗的主要限制。临床和,在一些患者中,超声评估是更好的访问计划的基础。访问计划不仅取决于患者的临床特征和偏好,而且还取决于血管遗产。因此,超声评估有助于表征患者的动脉和静脉上臂解剖结构,并提供更适合每个患者的信息。治疗CKD患者的医生应熟悉超声和多普勒在入路计划中的作用。
    Chronic kidney disease (CKD) is an emerging global burden with an increasing number of patient\'s requiring renal replacement therapy (RRT), with hemodialysis being the most prevalent dialysis modality. A functioning vascular access remains the main constrain for an adequate treatment. Clinical and, in some patients, ultrasound evaluation are fundamental for better access planning. Access planning is dependent not only on patient clinical characteristics and preference but also in vascular patrimony. As such, ultrasound evaluation aids in characterizing patient arterial and venous upper arm anatomy and provides information for which access would better suit each patient. Doctors dealing with CKD patients should be familiar with the role of ultrasound and Doppler use in access planning.
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  • 文章类型: Journal Article
    背景:在血液透析的血管通路(VA)手术之前,越来越多地使用双重超声(DUS)。然而,这种方法的成本效益是未知的。我们的目标是评估引入DUS评估的专业咨询是否会改变成本和时间延迟,以实现血液透析的第一个VA有效。
    方法:在与DUS(ECO组)进行专门会诊后,进行首次VA(2014年6月至2017年7月)的患者的前瞻性队列。将他们与历史队列(2012年1月至2014年5月)进行比较,其中VA仅通过临床评估(CLN组)表示。我们分析了与访问有关的费用,DUS评估,干预措施,至少在1个月内达到血液透析有效的第一个VA。
    结果:CLN组86例,ECO组92例。ECO组的患者年龄较小(68.4vs.64.0年;P=.038),但组间无其他差异。在ECO组中,实现血液透析的第一个AV有效的平均成本显着降低(2707与3347欧元;P=.024)。ECO组的DUS评估费用较高,但CLN组的随访费用较高,连续的手术干预,假肢材料,住院天数和导尿管。在ECO组中,实现血液透析的首次AV有效所需的平均时间也较短(49.9vs.82.9天,P=.002)。
    结论:在VA手术前对DUS进行专门的血管通路咨询,降低了实现血液透析有效的第一个VA所需的成本。从患者的角度来看,这意味着更少的干预措施和住院时间以及缩短的时间延迟。
    BACKGROUND: Duplex ultrasound (DUS) is increasingly used before vascular access (VA) surgery for haemodialysis. However, the cost-effectiveness of this approach is unknown. Our objective was to assess whether the introduction of a specialised consultation with DUS assessment modifies the cost and the time delay to achieve a first VA valid for haemodialysis.
    METHODS: Prospective cohort of patients undergoing a first VA (June 2014-July 2017) after a specialised consultation with DUS (ECO group). They were compared with a historical cohort (January 2012-May 2014) where VA was indicated exclusively by clinical evaluation (CLN group). We analysed the cost related to visits, DUS assessments, interventions, hospital admissions and graft materials to achieve a first VA valid for haemodialysis at least during 1 month.
    RESULTS: Eighty-six patients in the CLN group were compared with 92 in the ECO group. Patients in the ECO group were younger (68.4 vs. 64.0 years; P=.038) but no other differences were seen among groups. The average cost to achieve a first AV valid for haemodialysis was significantly lower in the ECO group (2707 vs. 3347€; P=.024). There was a higher cost associated with DUS assessments in the ECO group yet the CLN group had a higher cost related to follow-up visits, successive surgical interventions, prosthetic material, days of hospital admission and catheters. The mean time needed to achieve a first AV valid for haemodialysis was also shorter in the ECO group (49.9 vs. 82.9 days, P=.002).
    CONCLUSIONS: The introduction of a specialised vascular access consultation with DUS prior to VA surgery has reduced the cost necessary to achieve a first VA valid for haemodialysis. From the patient\'s point of view this has meant less interventions and hospital admissions and a shortening of the time delay.
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  • 文章类型: Journal Article
    慢性肾脏病(CKD)是一个新兴的全球负担,越来越多的患者需要肾脏替代治疗(RRT),血液透析是最普遍的透析方式。功能正常的血管通路仍然是适当治疗的主要限制。临床和,在一些患者中,超声评估是更好的访问计划的基础。访问计划不仅取决于患者的临床特征和偏好,而且还取决于血管遗产。因此,超声评估有助于表征患者的动脉和静脉上臂解剖结构,并提供更适合每个患者的信息。治疗CKD患者的医生应熟悉超声和多普勒在入路计划中的作用。
    Chronic kidney disease (CKD) is an emerging global burden with an increasing number of patient\'s requiring renal replacement therapy (RRT), with hemodialysis being the most prevalent dialysis modality. A functioning vascular access remains the main constrain for an adequate treatment. Clinical and, in some patients, ultrasound evaluation are fundamental for better access planning. Access planning is dependent not only on patient clinical characteristics and preference but also in vascular patrimony. As such, ultrasound evaluation aids in characterizing patient arterial and venous upper arm anatomy and provides information for which access would better suit each patient. Doctors dealing with CKD patients should be familiar with the role of ultrasound and Doppler use in access planning.
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  • 文章类型: Case Reports
    ARTERIOVENOUS: access creation is mandatory in patients with end stage renal disease for hemodialysis treatment. It frequently involves upper arm or axillary dissection and general anesthesia is predominantly used as axillary compartment innervation is complex. Avoiding general anesthesia may be beneficial in these risk patients. We present two cases where serratus-intercostal plane block (SIPB/BRILMA) was used, along with ultrasound guided supraclavicular block and multimodal analgesia for proximal arm and axillary AV access surgery. Regional anesthesia combination of supraclavicular and serratus-intercostal/BRILMA block in arteriovenous fistula surgery was successful and should be considered by anesthesiologist in order to avoid general anesthesia.
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  • 文章类型: Journal Article
    Traditionally, the indication of the type of vascular access (VA) has been based on the surgeon\'s physical examination, but it is now suggested that imaging methods could provide a clinical benefit. Our aim was to determine whether or not preoperative Doppler ultrasound modifies outcomes of the first VA for haemodialysis.
    Prospective cohort of patients undergoing a first VA from June 2014 to July 2017 who had a preoperative Doppler ultrasound (ECO group). They were compared to a historical cohort (January 2012-May 2014) of first VA indicated exclusively by clinical assessment (CLN group).
    A total of 86 patients from the CLN group were compared to 92 from the ECO group, which was younger (68.4 vs 64.0, P=.038). The primary patency (CLN/ECO) at 1 and 2years was 59.5%/71.9% and 53.1%/57.8% respectively, marginally better in the ECO group (P=.057). The assisted patency at 1 and 2years was 63.2%/80.7% and 58.1%/70.2%, respectively, significantly better for the ECO group (P=.010). Due to lack of patency/utility of the initial VA, 26.7% in the CLN group and 7.6% in the ECO group (P<.001) required a new VA during the first 6months. An average of 1.39 interventions were performed to achieve a useful VA in the CLN group and 1.08 in the ECO group (P<.001), the first VA being useful at the radiocephalic level in 31.0%/45.1% (P=.039).
    The indication of the first VA according to a preoperative Doppler ultrasound examination could decrease the need for new VA, enable them to be made more distal, and significantly improve patency.
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