目标:在法国,胚胎解冻涉及辅助生殖技术的45.8%的尝试,不包括人工授精。由于各种原因,这一比例不断增加。这项研究的主要目的是根据冷冻的初始指征比较冷冻胚泡移植(FBT)后的活产率。
方法:这是一项回顾性研究,包括2020年1月1日至2022年6月30日在图尔地区大学医院中心接受FBT的患者。结果进行了比较(单变量和多变量分析)的三个主要指标之间的冷冻:冷冻完整的囊胚队列的卵巢过度刺激的风险(=OHS),新鲜囊胚移植(BT)妊娠(=第二次请求)或未妊娠(=BT失败)后冷冻多余囊胚。还描述了其他适应症的结果。
结果:在选定的963个FBT周期中,28%的活产通过解冻获得,所有冻结的迹象相结合。与OHS组相比,FBT失败组的发生率明显较低。然而,调整后,对于处于冷冻周期的患者的年龄,结果仍然具有显著性,但对于冷冻适应症没有显著性.
结论:考虑到混杂因素,FBT的结果似乎不会受到冻结指征的显著影响。有必要对多中心研究的更多数据进行前瞻性分析,以证实这些结果。
OBJECTIVE: In France, embryo thawing concern 45.8% of attempts at assisted reproductive technologies excluding artificial inseminations. This proportion is constantly increasing for various reasons. The main objective of this study is to compare the live birth rate following frozen blastocyst transfer (FBT) according to the initial indication for freezing.
METHODS: This is a retrospective study including patients who underwent FBT between 01/01/2020 and 06/30/2022 at the Regional University Hospital Center of Tours. The results were compared (univariate and multivariate analyses) between the three main indications for freezing: freezing of the complete cohort of blastocysts for risk of ovarian hyperstimulation (=OHS), freezing of supernumerary blastocysts after fresh blastocyst transfer (BT) with pregnancy (=second request) or without pregnancy (=BT failure). Results have also been described for other indications.
RESULTS: Among the 963 FBT cycles selected, 28% of live births by thawing were obtained, all indications of freezing combined. A significantly lower rate was identified in the FBT failure group compared to the OHS group. However, after adjustment, the results remained significant for the age of the patient on the freezing cycle but not for the indication for freezing.
CONCLUSIONS: The outcome of a FBT does not seem significantly impacted by the indication of freezing considering the confounding factors. The prospective analysis of more data from a multicenter study would be necessary to confirm these results.