目的:结肠癌的发病率急剧增加。此外,该数据库缺乏对中横结结肠癌手术结局进行分析的综述,近期有几项有争议的研究.我们旨在比较扩大半结肠切除术与横结肠切除术治疗中横结肠癌的结果。
方法:PubMed,范围,从开始到2022年12月1日,搜索了WebofScience和CochraneLibrary的合格研究,并进行了系统评价和荟萃分析以检测。
结果:根据资格标准,我们的研究包括8项研究(2237例患者)。纳入研究的汇总结果显示,5年OS没有差异,两种手术类型之间的3年DFS和5年DFS(5年OS,RR=1.15,95%CI0.94-1.39,P=0.17),(3年操作系统,RR=0.96,95%CI0.88-1.06,P=0.42)和(5年DFS,RR=1.21,95%CI0.91-1.62,P=0.20)。除此之外,两组的复发率和并发症发生率相似(复发率,RR=1.08,95%CI0.62-1.89,P=0.79)和(并发症,RR=1.07,95%CI0.74-1.54,P=0.72)。然而,在扩大半结肠切除术的情况下,LN收获的数量和手术时间更多。
结论:尽管收获的LN较少,横结肠切除术与扩大半结肠切除术治疗中横结肠结肠癌的肿瘤学结果相似.除此之外,两种手术的并发症发生率无显著差异。
OBJECTIVE: The incidence of cancer colon has increased dramatically. In addition, the database lacks a review to analyze the outcomes of surgeries for mid-transverse colon cancer with several recent controversial studies. We aimed to compare the outcomes of extended hemicolectomy versus transverse colectomy for mid-transverse colon cancer.
METHODS: PubMed, Scopes, Web of Science and Cochrane Library were searched for eligible studies from inception to 1 December 2022 and a systematic review and meta-analysis were done to detect.
RESULTS: According to eligibility criteria, 8 studies (2237 patients) were included in our study. The pooled results of the included studies showed no difference in the 5-year OS, 3-year DFS and 5-year DFS between the two types of surgery (5-year OS, RR = 1.15, 95% CI 0.94-1.39, P = 0.17), (3-year OS, RR = 0.96, 95% CI 0.88-1.06, P = 0.42) and (5-year DFS, RR = 1.21, 95% CI 0.91-1.62, P = 0.20). In addition to that, the recurrence rate and the incidence of complications were similar in the two groups (Recurrence rate, RR = 1.08, 95% CI 0.62-1.89, P = 0.79) and (Complications, RR = 1.07, 95% CI 0.74-1.54, P = 0.72). However, the number of LN harvest and the time of the operation were more in case of extended hemicolectomy.
CONCLUSIONS: Despite harvesting less LN, transverse colectomy has similar oncological outcomes to extended hemicolectomy for mid-transverse colon cancer. In addition to that, there was no significant difference in the incidence of complications between the two surgeries.