背景:本研究的目的是评估因眶周行眼眶切除术患者的总生存期(OS)和无病生存期(DFS),结膜,和原发性眶内癌。此外,我们评估了前逆行颞肌皮瓣修复的结果。
方法:对于所有在过去五年内接受过眼眶切除术的患者,对他们的医疗记录进行非比较回顾性评估,组织学,并进行了射线照相成像。我们使用Cramer的VKaplan-Meier(KM)分析研究了各种定性因素之间的关系。对于患者的每一个相关的分类因素,显示了对生存分布的估计,和对数秩检验用于确定生存分布是否相等。
结果:本研究调查了19名参与者。样本由13名男性(68%)和6名女性(32%)组成。淋巴结转移(N)与远处转移(M)之间的关系程度(CramerV指数)很高,64%,并且具有统计学意义,因为p值为0.0034<0.005。淋巴结转移对总生存期有统计学显著影响(p=0.04<0.05)。测试的19名患者中有13名没有麻痹(68%)。没有人出现CSF泄漏。
结论:我们的研究结果表明,识别眼眶肿瘤可能累及的淋巴结是多么重要。在接受过许多治疗的患者中,前哨淋巴结活检(SLNB)可用于确定癌症的分期和扩散。为了确定是否可以探索其他肿瘤特征,对于接受过多种治疗的眼眶癌患者,SLNB领域的更多专业知识可能会有所帮助.为了防止额外的疤痕,并与以前的面神经损伤技术相当,前逆行入路和经眶内固定颞肌皮瓣都是有效的方法。
BACKGROUND: The purpose of this study was to assess the overall survival (OS) and disease-free survival (DFS) of patients who underwent orbital
exenteration for periorbital, conjunctival, and primary intraorbital carcinomas. Additionally, we assessed the outcomes of anterior retrograde temporalis muscle flap restoration.
METHODS: For all patients who had orbital
exenteration in the previous five years, a non-comparative retrospective assessment of their medical records, histology, and radiographic imaging was carried out. We investigated the relationships between the various qualitative factors using Cramer\'s V Kaplan-Meier (KM) analysis. For each of the patient\'s categorical factors that were of relevance, estimates of the survival distribution were displayed, and log-rank tests were used to determine whether the survival distributions were equal.
RESULTS: This study looks at 19 participants. The sample is made up of 13 men (68%) and 6 women (32%). The degree of relationship (Cramer\'s V index) between lymph node metastases (N) and the existence of distant metastases (M) is high, at 64%, and is statistically significant because the p-value is 0.0034 < 0.005. Lymph node metastases had a statistically significant impact on overall survival (p = 0.04 < 0.05). Thirteen of the nineteen patients tested had no palsy (68%). There was no one presenting a CSF leak.
CONCLUSIONS: Our findings show how crucial it is to identify any lymph node involvement that orbital neoplasms may have. In patients who have received many treatments, sentinel lymph node biopsy (SLNB) may be used to determine the stage and spread of the cancer. To determine whether additional tumor characteristics may be explored, more expertise in the SLNB field for patients with orbital cancer who have received many treatments may be helpful. To prevent additional scarring and to be comparable to previous techniques for facial nerve lesions, the anterior retrograde approach and the transorbital procedure for temporal muscle flap in-setting are both effective methods.