背景:心房颤动(AF)的导管消融包括肺静脉隔离和可能的进一步基质消融是最常见的电生理程序。严重的并发症并不常见,但缺乏他们在全球大型队列中的详细评估。
目的:本研究的目的是确定房颤消融术患者围手术期严重并发症的发生率,并对这些并发症的诊断评估和处理提供详细的描述。
方法:从全球23个中心收集个体患者数据。对所有接受导管消融的患者收集的数据有限,我们为在围手术期随访期间出现严重并发症的患者收集了一系列扩展的数据点.发病率,预测因子,患者特征,管理细节,并对消融相关并发症患者的总体结局进行了调查.
结果:数据来自23个参与中心,其中进行了33,879次手术(中位年龄63岁,30%的女性,71%的射频消融)。严重并发症的发生率(n=271)低(填塞6.8‰,中风0.97‰,心脏骤停0.41‰,食管瘘0.21‰,死亡0.21‰)。年龄,女性性别,扩张的左心房,程序持续时间,射频能量的使用与所有严重并发症的复合终点独立相关。在经历填塞的患者中,13%需要心脏手术。93%的并发症患者在中位住院时间为5天(Q1-Q3:3-7天)后直接出院。
结论:这项大型全球合作研究强调,填塞,中风,心脏骤停,食管瘘,房颤消融术后死亡罕见。年纪大了,女性性别,程序持续时间,扩张的左心房,在这个跨国队列中,射频能量的使用与严重并发症相关.八分之一的填塞患者需要心脏手术。
BACKGROUND: Catheter ablation for atrial fibrillation (AF) including pulmonary vein isolation and possibly further substrate ablation is the most common electrophysiological procedure. Severe complications are uncommon, but their detailed assessment in a large worldwide cohort is lacking.
OBJECTIVE: The aim of this study was to determine the incidence of periprocedural severe complications and to provide a detailed characterization of the diagnostic evaluation and management of these complications in patients undergoing AF ablation.
METHODS: Individual patient data were collected from 23 centers worldwide. Limited data were collected for all patients who underwent catheter ablation, and an expanded series of data points were collected for patients who experienced severe complications during periprocedural follow-up. Incidence, predictors, patient characteristics, management details, and overall outcomes of patients who experienced ablation-related complications were investigated.
RESULTS: Data were collected from 23 participating centers at which 33,879 procedures were performed (median age 63 years, 30% women, 71% radiofrequency ablations). The incidence of severe complications (n = 271) was low (tamponade 6.8‰, stroke 0.97‰, cardiac arrest 0.41‰, esophageal fistula 0.21‰, and death 0.21‰). Age, female sex, a dilated left atrium, procedure duration, and the use of radiofrequency energy were independently associated with the composite endpoint of all severe complications. Among patients experiencing tamponade, 13% required cardiac surgery. Ninety-three percent of patients with complications were discharged directly home after a median length of stay of 5 days (Q1-Q3: 3-7 days).
CONCLUSIONS: This large worldwide collaborative study highlighted that tamponade, stroke, cardiac arrest, esophageal fistula, and death are rare after AF ablation. Older age, female sex, procedure duration, a dilated left atrium, and the use of radiofrequency energy were associated with severe complications in this multinational cohort. One in 8 patients with tamponade required cardiac surgery.