间质性膀胱炎/膀胱疼痛综合征(IC/BPS)是一种慢性疼痛障碍,以急迫为特征,排尿频率,和骨盆疼痛。患有IC/BPS的女性经常经历性功能障碍,外阴痛,和阴道健康问题。针对阴道和外阴的铒和钕钇铝石榴石(YAG)组合激光治疗已显示出改善症状的希望。我们的研究旨在调查这些联合激光治疗对IC/BPS和外阴痛女性的有效性。方法对诊断为外阴痛和IC/BPS的妇女进行阴道铒:YAG激光(VEL)和钕:YAG激光(Nd:YAG)联合激光治疗。评估了各种参数,包括外阴痛试验,疼痛数字评定量表(NRS-11),间质性膀胱炎症状指数和问题指数(ICSI和ICPI),盆腔疼痛和尿急/频率症状评分(PUF),和三天排尿日记中的平均排尿量/每日排尿频率。治疗三次,每次会议之间间隔一个月,随访评估在6个月和12个月进行.所有统计分析均由AI聊天机器人GPT-4(chatGPT-4)设计和编程。结果15例诊断为外阴痛和IC/BPS的女性患者接受了3次VELNd:YAG治疗。在外阴痛试验中观察到显著改善,NRS-11评分,PUF,ICSI分数,ICPI分数,平均排尿量,6个月和12个月时的每日排尿频率(p<0.01)。IC/BPS疼痛评分的短期改善与外阴痛测试的改善相关(p=0.007),表明有协同效应。然而,在12个月时没有发现显著的相关性.结论针对阴道和外阴的联合激光治疗对IC/BPS合并外阴痛的女性具有明显的治疗效果。在VEL治疗中添加Nd:YAG可提高预后。IC/BPS疼痛评分的短期改善与外阴痛测试的改善相关,表明协同效应。外阴痛和IC/BPS症状的长期改善可能独立发生。这些发现强调了综合治疗外阴痛和IC/BPS共存的方法的重要性。
Introduction Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic pain disorder characterized by urgency, frequency of urination, and pelvic pain. Women with IC/BPS often experience sexual dysfunction, vulvodynia, and vaginal health issues. Combined erbium and neodymium yttrium aluminum garnet (YAG) laser treatments targeting the vagina and vulva have shown promise in improving symptoms. Our study aims to investigate the effectiveness of these combined laser treatments in women with IC/BPS and vulvodynia. Methods Women diagnosed with vulvodynia and IC/BPS underwent combined laser treatment using vaginal erbium:YAG laser (VEL) and neodymium:YAG laser (Nd:YAG). Various parameters were evaluated, including the vulvodynia test, numeric rating scale (NRS-11) for pain, interstitial cystitis symptom index and problem index (ICSI and ICPI), pelvic pain and urgency/frequency symptom score (PUF), and mean urination volume/daily urination frequency in a three-day urination diary. Treatment was administered three times, with intervals of one month between each session, and follow-up evaluations were conducted at six and 12 months. All statistical analyses were designed and programmed by the AI chatbot GPT-4 (chatGPT-4). Results Fifteen female patients diagnosed with vulvodynia and IC/BPS were treated with three sessions of VEL + Nd:YAG. Significant improvements were observed in the vulvodynia test, NRS-11 scores, PUF, ICSI scores, ICPI scores, mean urination volume, and daily urination frequency at six and 12 months (p<0.01). Short-term improvements in IC/BPS pain scores correlated with improvements in the vulvodynia test (p=0.007), suggesting a synergistic effect. However, no significant correlations were found at 12 months. Conclusion Combined laser treatments targeting the vagina and vulva showed significant therapeutic effects in women with IC/BPS and vulvodynia. The addition of Nd:YAG to the VEL treatment enhanced outcomes. Short-term improvements in IC/BPS pain scores correlated with improvements in the vulvodynia test, indicating a synergistic effect. Long-term improvements in both vulvodynia and IC/BPS symptoms may occur independently. These findings highlight the importance of comprehensive approaches for treating coexisting vulvodynia and IC/BPS.