Eph受体构成受体酪氨酸激酶的最大家族,由14个不同的成员组成,分为两个亚组:EphAs和EphB。.尽管它们在正常生理过程中起着重要作用,越来越多的证据表明,Eph家族参与癌症的特征是双重的,并且通常是矛盾的。研究表明Eph/ephrin双向信号传导影响细胞间的通讯,随后调节细胞迁移,附着力,分化和增殖。相互矛盾的功能可能来自Eph信号通路的多样性和不同癌症微环境的异质性。在这次审查中,我们的目的是讨论Eph受体在肿瘤发展中的双重作用,试图通过探索Eph受体信号通路来阐明矛盾的功能,血管生成,免疫反应,还有更多.我们的目标是全面了解肿瘤发展的分子机制。此外,我们将探索利用Eph受体作为肿瘤治疗和诊断工具的潜在靶标的演变前景。
Eph receptors constitute the largest family of receptor tyrosine kinases, comprising 14 distinct members classified into two subgroups: EphAs and EphBs.. Despite their essential functions in normal physiological processes, accumulating evidence suggests that the involvement of the Eph family in cancer is characterized by a dual and often contradictory nature. Research indicates that Eph/ephrin bidirectional signaling influences cell-cell communication, subsequently regulating cell migration, adhesion, differentiation and proliferation. The contradictory functionalities may arise from the diversity of Eph signaling pathways and the heterogeneity of different cancer microenvironment. In this review, we aim to discuss the dual role of the Eph receptors in tumor development, attempting to elucidate the paradoxical functionality through an exploration of Eph receptor signaling pathways, angiogenesis, immune responses, and more. Our objective is to provide a comprehensive understanding of the molecular mechanisms underlying tumor development. Additionally, we will explore the evolving landscape of utilizing Eph receptors as potential targets for tumor therapy and diagnostic tools.