背景:阑尾炎是急性腹部手术的最常见原因之一。在伊朗西南部的大规模阑尾切除术标本中,寄生虫病因在阑尾炎发病机理中的重要性尚不为人所知。本研究旨在回顾性评估法尔斯省28年来阑尾炎的人口统计数据和组织病理学记录,伊朗西南部。
方法:在AliShariati医生医院接受阑尾炎手术的13,013例患者的组织病理学记录,从1993年12月至2021年1月,本研究对Fasa医科大学的附属机构进行了审查,并从每个记录中检索了有关患者的人口统计学数据和组织病理学记录.还审查了超过6800个存档的显微镜载玻片。
结果:从28年期间回顾的13,013例阑尾炎手术切除的组织病理学记录中,男性为8,189(62.9%),女性为4,842(37.1%)。患者年龄从2岁到98岁,平均年龄为24.68±19.87岁。最常见的炎症变化是5,687(43.7%),1,228(9.4%),670(5.1%),522(4%),和363例(2.8%)急性阑尾炎,化脓性阑尾炎,早期急性阑尾炎,坏疽性阑尾炎,和穿孔性阑尾炎。微观上,没有病毒包涵体,真菌元素,和细菌原因的组织病理学发现。在74例(0.6%)6至63岁的病例中检测到寄生虫感染,例如蠕虫病。肠病(Syn。催尿症,pin虫感染)占74种蠕虫病的73种(98.6%),而蛔虫病占1(1.4%)。在74个案例中,29(39.2%)显示阑尾炎的证据。
结论:结果表明,尽管寄生虫是阑尾炎的次要原因,鉴别诊断时应牢记这些药物.然而,是否每一个寄生虫感染导致阑尾炎是有争议的。
BACKGROUND: Appendicitis is one of the most common causes of acute abdominal surgeries. The importance of parasitic etiologies in the pathogenesis of appendicitis is not well known in appendectomy specimens on a large scale in southwestern Iran. The current study aimed to retrospectively assess the demographic data and histopathological records of appendicitis in a 28-year period in Fars province, southwestern Iran.
METHODS: Histopathological records of 13,013 patients who had undergone surgeries for appendicitis at Dr. Ali Shariati Hospital, affiliated with the Fasa University of Medical Sciences from December 1993 to January 2021 were reviewed and data concerning the patients\' demographic data and histopathological records were retrieved from each record. More than 6800 archived microscopic glass slides were also reviewed.
RESULTS: From a total of 13,013 histopathological records of surgical excisions of appendicitis that were reviewed over a 28-year period, 8,189 (62.9%) were male and 4,842 (37.1%) were female. Patients\' age ranged from 2 to 98 years, with a mean age of 24.68±19.87 years. The most common inflammatory changes were 5,687 (43.7%), 1,228 (9.4%), 670 (5.1%), 522 (4%), and 363 (2.8%) cases of acute appendicitis, suppurative appendicitis, early acute appendicitis, gangrenous appendicitis, and perforated appendicitis respectively. Microscopically, no viral inclusions, fungal elements, and histopathologic findings of bacterial causes were found. Parasitic infections such as helminthiasis were detected in 74 (0.6%) cases aged from 6 to 63. Enterobiasis (Syn. oxyuriasis, pinworm infection) accounted for 73 (98.6%) of the 74 helminthiases, while ascariasis accounted for 1 (1.4%). Out of 74 cases, 29 (39.2%) showed evidence of appendicitis.
CONCLUSIONS: The results suggest that although parasitic agents are minor causes of appendicitis, these agents should be kept in mind during differential diagnosis. However, whether every parasitic infection leads to appendicitis is controversial.