肠道炎症的程度很大程度上取决于肠道屏障的完整性和肠道神经免疫相互作用。然而,调节肠神经系统(ENS)炎症相关变化的因素和分子机制在很大程度上仍未被研究.Eph/ephrin信号对炎症反应至关重要，神经元激活，大脑的突触可塑性，但迄今为止，它在ENS中的存在和功能在很大程度上是未知的。这篇综述讨论了Eph/ephrin在调节肠道稳态中的关键作用，炎症,神经免疫相互作用，和疼痛路径。针对Eph/ephrin系统为肠道炎症疾病提供创新的治疗方法，为改善患者预后提供希望，疼痛管理,和整体生活质量。
The extent of gut inflammation depends largely on the gut barrier\'s integrity and enteric neuroimmune interactions. However, the factors and molecular mechanisms that regulate inflammation-related changes in the enteric nervous system (ENS) remain largely unexplored. Eph/ephrin signaling is critical for inflammatory response, neuronal activation, and synaptic plasticity in the brain, but its presence and function in the ENS have been largely unknown to date. This review discusses the critical role of Eph/ephrin in regulating gut homeostasis, inflammation, neuroimmune interactions, and pain pathways. Targeting the Eph/ephrin system offers innovative treatments for gut inflammation disorders, offering hope for enhanced patient prognosis, pain management, and overall quality of life.
