目的:支架诱导的导管改变(SIDC)是慢性胰腺炎(CP)患者内镜下胰腺支架置入术(EPS)的并发症。然而,与S型胰腺塑料支架(PS)和大口径PS相关的SIDC的评价,例如10Fr,是有限的。本研究旨在分析CP患者与10-FrS型PS相关的主胰管(MPD)SIDC。
方法:在2008年1月至2021年12月之间,对132例CP患者进行了回顾性分析,其中通过EPS安装了10-FrS型PS。检查了SIDC的发生率,并研究了有和没有SIDC的患者的临床特征,包括检测到的SIDC的结果。
结果:在132例患者中,有41例患者(31.1%)在与MPD中PS尖端或远端皮瓣一致的部位证实了EPS期间支架引起的导管改变。所有患者在SIDC发展过程中无症状。MPD的形态变化被检测为升高(75.6%)或带有狭窄变化(24.4%)。在第一次10-FrPS安装后,总共开发了90.2%的SIDC。在有和没有SIDC的患者之间没有发现显着差异。SIDC连续PS分期付款的结果显示了持久性和次要变化。
结论:支架诱导的导管改变相关的10-FrPS安装在不到三分之一的患者中进行,表明从早期阶段开始SIDC的发病率和可能的发展。作为并发症,应更加重视SIDC。
OBJECTIVE: Stent-induced ductal change (SIDC) is a complication of endoscopic pancreatic stenting (EPS) in patients with chronic pancreatitis (CP). However, the evaluation of SIDC associated with S-type pancreatic plastic stent (PS) and large-caliber PS, such as 10 Fr, is limited. This study aimed to analyze the SIDC of the main pancreatic duct (MPD) associated with 10-Fr S-type PS in patients with CP.
METHODS: Between January 2008 and December 2021, 132 patients with CP in whom a 10-Fr S-type PS had been installed by EPS were retrospectively reviewed. The SIDC incidence rate was examined, and the clinical features of patients with and without SIDC were investigated, including the outcomes for detected SIDC.
RESULTS: Stent-induced ductal change during EPS was confirmed in 41 patients (31.1%) of 132 patients at a site coincident with the PS tip or distal flap in the MPD. All patients were asymptomatic during the development of SIDC. Morphological changes in the MPD were detected as elevated (75.6%) or bearing stricture changes (24.4%). A total of 90.2% of SIDC developed after the first 10-Fr PS installation. No significant differences were noted between the patients with and without SIDC. The outcomes of continued PS installment for SIDC showed persistence and secondary change.
CONCLUSIONS: Stent-induced ductal change-associated 10-Fr PS installation was performed in just under one-third of the patients, indicating a substantial incidence rate and a possible development of SIDC from early stages onwards. More emphasis should be placed on SIDC as the complication.