目的研究来自滑面内质网聚集体(SERa)的囊胚阳性周期和卵母细胞的整倍体率是否受到影响。
回顾性队列研究。
该研究最初包括2017年4月至2021年5月在我们中心检索到的至少一个卵母细胞的总共601个植入前遗传测试(PGT)周期。>35岁的女性和PGT周期的染色体结构重排(PGT-SR)被排除。在SERA+卵母细胞中比较了胚胎学和囊胚倍性结果,同胞SERa-卵母细胞和SERa-周期中的卵母细胞。
在SERa+卵母细胞组中没有观察到显著差异,兄弟姐妹SERa-卵母细胞组,和SERa周期组的正常受精率(82.1%vs.77.8%vs.83.1%,分别,P=0.061),囊胚形成率(71.0%vs.72.5%vs.68.4%,分别,P=0.393),优质囊胚形成率(46.4%vs.48.3%vs.42.6%,分别,P=0.198)。整倍体率无显著差异(50.0%vs.62.5%与63.3%,分别,P=0.324),马赛克率(12.5%vs.9.7%与13.4%,分别,P=0.506),和非整倍体率(37.5%vs.27.8%与23.2%,分别,三组间P=0.137)。
我们的结果表明,来自SERA周期和卵母细胞的胚泡的整倍体率可能不会受到影响。
To investigate whether the euploidy rate of blastocysts derived from smooth endoplasmic reticulum aggregates (SERa) positive cycles and oocytes are impacted.
Retrospective cohort study.
A total of 601 preimplantation genetic testing (PGT) cycles with at least one oocyte retrieved in our center between April 2017 and May 2021 were initially included in the study. Women>35 years and PGT cycles with chromosomal structural rearrangements (PGT-SR) were excluded. Embryological and blastocyst ploidy outcomes were compared among SERa+ oocyte, sibling SERa- oocytes and oocytes in SERa- cycles.
No significant difference was observed among the SERa+ oocyte group, sibling SERa- oocyte group, and SERa- cycle group in the normal fertilization rate (82.1% vs. 77.8% vs. 83.1%, respectively, P=0.061), blastocyst formation rate (71.0% vs. 72.5% vs. 68.4%, respectively, P=0.393), good quality blastocyst formation rate (46.4% vs. 48.3% vs. 42.6%, respectively, P=0.198). No significant difference was observed in the euploidy rate (50.0% vs. 62.5% vs. 63.3%, respectively, P=0.324), mosaic rate (12.5% vs. 9.7% vs. 13.4%, respectively, P=0.506), and aneuploidy rate (37.5% vs. 27.8% vs. 23.2%, respectively, P=0.137) among the three groups.
Our results suggest that the euploidy rate of blastocysts derived from SERa+ cycles and oocytes may not be impacted.