水生生态系统面临大量暴露于内分泌干扰化学物质(EDCs),可以模仿,块,或改变内源性激素的合成。双酚A(BPA),众所周知的EDC,由于担心其对人类健康的潜在影响,已从消费品中逐步淘汰。在它的地方,双酚S(BPS),一种有机化合物,越来越多地用于聚碳酸酯塑料的生产,环氧树脂,热收据,和货币。卵黄蛋白原(Vtg),一种在肝脏中合成并存在于卵生鱼中的卵黄前体蛋白,尤其是男性,作为研究雌激素EDC对鱼类影响的相关生物标志物。本研究旨在评估BPS对Channa纹状体生殖参数和肝卵黄蛋白原表达的影响。测定BPS的LC50为128.8mg/L。实验组包括对照和BPS暴露的鱼,亚致死浓度的BPS(1mg/L,4mg/L,和12mg/L)以7天和21天的间隔给药并监测效果。性腺指数(GSI)显著下降,ova直径,在暴露于BPS的Channa纹状体中观察到繁殖力。BPS暴露后,女性肝VtgmRNA表达下调,男性肝VtgmRNA表达上调。血清激素分析证实了BPS的雌激素活性。这些发现强调了BPS作为内分泌干扰物干扰激素合成并破坏Channa纹状体精子发生和卵子发生过程的能力。这项研究有助于了解BPS对水生生物的内分泌干扰作用,强调潜在的生态影响以及持续监测和监管考虑的必要性。
Aquatic ecosystems face significant exposure to endocrine-disrupting chemicals (EDCs), which can mimic, block, or alter the synthesis of endogenous hormones. Bisphenol A (BPA), a widely known EDC, has been phased out from consumer products due to concerns about its potential impacts on human health. In its place, bisphenol S (BPS), an organic compound, has been increasingly used in the production of polycarbonate plastics, epoxy resins, thermal receipt papers, and currency. Vitellogenin (Vtg), a yolk precursor protein synthesized in the liver and present in oviparous fish, particularly males, serves as a pertinent biomarker for studying the effects of estrogenic EDCs on fish. This study aimed to assess the impact of BPS on reproductive parameters and hepatic vitellogenin expression in Channa striatus. The LC50 of BPS was determined to be 128.8 mg/L. Experimental groups included control and BPS-exposed fish, with sub-lethal concentrations of BPS (1 mg/L, 4 mg/L, and 12 mg/L) administered and effects monitored at seven- and twenty-one-day intervals. Significant decreases in gonadosomatic index (GSI), ova diameter, and fecundity were observed in BPS-exposed Channa striatus. Hepatic Vtg mRNA expression was downregulated in female and upregulated in male following BPS exposure. Serum hormone analysis confirmed the estrogenic activity of BPS. These findings underscore BPS\'s ability as an endocrine disruptor to interfere with hormone synthesis and disrupt spermatogenesis and oogenesis processes in Channa striatus. This research contributes to understanding the endocrine-disrupting effects of BPS on aquatic organisms, highlighting potential ecological implications and the need for continued monitoring and regulatory considerations.