■土壤传播的蠕虫是世界上智力和身体残疾的最普遍原因之一。阿苯达唑(ALB)是一种推荐用于大规模治疗学龄儿童土壤传播的蠕虫的高负担的药物,特别是在发展中国家。然而,一些研究人员报告说,阿伯达唑对土壤传播的蠕虫的功效不一致。监测这些计划对于评估400毫克ALB对抗土壤传播的蠕虫的有效性至关重要,以及其治疗效果的任何变化。因此,这项研究的目的是评估ALB在治疗Salgy小学生土壤传播的蠕虫中的有效性。
■在Salgy小学生中进行了一项不受控制的实验研究,埃塞俄比亚西北部,2020年3月至5月。总共招募了439名学童,并通过分层比例系统随机抽样对土壤传播的蠕虫进行了筛查,以获得228名阳性学童。一年级至八年级的学生根据他们的教育程度进行分组。使用加藤-卡茨厚涂片技术,使用Kato-Katz厚涂片技术对从学童收集的粪便样本进行检查,以确定治愈率和减卵率.社会科学软件统计软件包,版本20,用于分析数据。确定按年龄划分的CR(治愈率)和ERR(减蛋率)之间的关系,采用卡方检验(X2),在95%置信区间和p值(p<0.05)下考虑显著性。
■400mg单剂量的ALB显示出99.35%的CR和97.30%的减卵率。此外,400毫克剂量的ALB显示95.75%的CR和82.07%的减卵率,对钩虫感染的有效性有疑问。Trichuristrichiura显示疗效下降,CR为43.53%,减蛋率为23.12%。
■单剂量400毫克ALB有效(令人满意),令人怀疑,对蛔虫不能令人满意,钩虫,和Trichura感染,分别。使用不同品牌的进一步研究,剂量,并且需要通过使用更大的样本量来成功治疗钩虫和Trichuura感染的途径。
UNASSIGNED: Soil-transmitted helminths are one of the most prevalent causes of both intellectual and physical disability in the world. Albendazole (ALB) is a drug recommended for mass treatment of the high burden of soil-transmitted helminths in schoolchildren, particularly in developing countries. However, some researchers have reported that the efficacy of albedazole against soil-transmitted helminths is inconsistent. Monitoring the programs is crucial to evaluating the effectiveness of 400 mg of ALB against soil-transmitted helminths, as well as any changes in its therapeutic efficacy. Thus, the purpose of this study was to evaluate ALB effectiveness in treating soil-transmitted helminthes in Salgy Primary School Children.
UNASSIGNED: An uncontrolled experimental study was conducted at Salgy Primary School Children, Northwest Ethiopia, from March to May 2020. A total of 439 schoolchildren were enrolled and screened for soil-transmitted helminths by stratified proportionate systematic random sampling to get 228 positive schoolchildren. Students in grades one through eight were grouped based on their educational attainment. Using the Kato-Katz thick smear technique, the selected stool sample collected from school children was examined using the Kato-Katz thick smear technique to determine the cure and egg reduction rates. The statistical package for social science software, version 20, was used to analyze the data. To determine the relationship between CR (cure rate) and ERR (egg reduction rate) by age, a chi-square test (X 2) was employed and significance was considered at A 95% confidence interval and p Value (p < 0.05).
UNASSIGNED: A 400 mg single dosage of ALB showed a 99.35% CR and a 97.30% egg reduction rate against Ascaris lumibricoides. Additionally, a 400 mg dose of ALB showed a 95.75% CR and an 82.07% egg reduction rate, suggesting questionable effectiveness against hookworm infections. Trichuris trichiura showed a decreased efficacy, with a 43.53% CR and a 23.12% egg reduction rate.
UNASSIGNED: A single dose of 400 mg ALB is effective (satisfactory), doubtful, and unsatisfactory against Ascaris lumbricoides, hookworm, and T. trichiura infections, respectively. Further studies using different brands, doses, and routes will be needed to treat hookworm and T. trichiura infections successfully by using a larger sample size.