尽管急性心包填塞是临床实践中的主要问题之一,仍然缺乏合适的动物模型。我们试图通过回声引导的导管操作在猕猴中产生急性心脏压塞。一只13岁的雄性猕猴被麻醉,在经胸超声心动图引导下,通过左颈动脉将长鞘插入左心室。然后将鞘管插入左冠状动脉的孔口以在左前降支的近端部位穿孔。心脏压塞已成功创建。通过导管将稀释的造影剂注入心包腔,可以在死后计算机断层扫描中清楚地区分心包和周围组织。该程序在导管插入期间不需要X射线成像系统。我们目前的模型将帮助我们检查存在急性心脏压塞的胸内器官。
Although acute cardiac tamponade is one of the major problems in clinical practice, a suitable animal model is still lacking. We tried to create acute cardiac tamponade in macaques by echo-guided catheter manipulation. A 13-year-old male macaque was anesthetized, and a long sheath was inserted into the left ventricle via the left carotid artery under the guidance of transthoracic echocardiography. The sheath was then inserted into the orifice of the left coronary artery to perforate the proximal site of the left anterior descending branch. A cardiac tamponade was successfully created. Injection of diluted contrast agent into the pericardial space via a catheter made it possible to clearly distinguish between the hemopericardium and the surrounding tissues on postmortem computed tomography. This procedure did not need an X-ray imaging system during catheterization. Our present model would help us examine the intrathoracic organs in the presence of acute cardiac tamponade.