■偏心肌肉收缩引起不同的生理反应,包括细胞因子谱的调节。虽然与康复有关,在多发性硬化症(MS)中,从未研究过偏心肌肉训练对免疫系统的影响。
■检查白细胞介素-4(IL-4)的即时细胞因子反应,IL-6,IL-10,IL-17a,干扰素-γ,在患有MS的个体中进行中度偏心训练后,和肿瘤坏死因子-α。此外,进一步研究静息时全身细胞因子水平与活动度和下肢功能强度的临床指标之间的关系.
■观察性研究。
■第一疗程包括用于基线细胞因子测量的血液取样。随后,参与者完成了一系列与活动能力和下肢力量相关的临床评估,也就是说,定时上行测试,五次重复坐立测试(5STS),四方阶跃测试,和两分钟步行测试。第二节包括偏心运动训练课,随后进行第二次血液采样,以评估对偏心训练回合的急性细胞因子反应。本次会议包括10项练习,重点是躯干和下肢的力量。
■27名MS(pwMS)患者,平均年龄为40.1岁,参与研究。基线与偏心训练后即刻之间的细胞因子浓度值没有差异。5STS解释了与干扰素-γ相关的30.3%的变异,14.8%与IL-4,13.8%与IL-10。
■偏心训练不会影响血液中的细胞因子浓度,因此,不会促进促炎反应,因此,它可以在pwMS上进行康复设置。
延长强度的锻炼不会影响多发性硬化症患者的炎症标志物。叫做偏心肌肉训练,影响多发性硬化症(MS)患者。偏心肌肉训练涉及肌肉在张力下延长的练习,就像你慢慢放下重物一样。这种类型的运动以引起独特的身体反应而闻名,包括血液中某些有助于控制免疫系统和炎症的蛋白质的变化。这项研究的主要目的是观察一次偏心肌肉训练是否会改变这些蛋白质的水平,称为细胞因子,运动后立即在MS患者的血液中。研究的细胞因子包括IL-4,IL-6,IL-10,IL-17a,INF-γ,和TNF-α。这些蛋白质很重要,因为它们有助于调节炎症和免疫反应。研究人员还想知道这些蛋白质在休息时的水平与移动性和腿部力量的测量之间是否有任何联系。27名MS患者参加了这项研究。他们的平均年龄为40.1岁。在第一次会议中,采取血液样本来测量这些蛋白质的基线水平,并进行了各种测试以评估活动能力和腿部力量。在第二届会议上,参与者完成了一次古怪的培训课程,然后立即采集另一个血液样本,看看蛋白质水平是否有任何立即的变化。结果表明,运动前后蛋白质水平没有显着差异。这表明,一次偏心肌肉训练不会引起血液中的立即炎症反应。因此,这种类型的运动可以安全地纳入MS患者的康复计划,而不会引起有害炎症。总的来说,该研究支持对MS患者进行偏心肌肉训练的安全性,并为其对免疫系统的直接影响提供了有价值的见解。
UNASSIGNED: Eccentric muscle contractions elicit distinct physiological responses, including modulation of the cytokine profile. Although relevant for rehabilitation, the effect of eccentric muscle training on the immune system has never been investigated in multiple sclerosis (MS).
UNASSIGNED: Examine the immediate cytokine response of interleukin-4 (IL-4), IL-6, IL-10, IL-17a, interferon-gamma, and tumor necrosis factor-alpha after a moderate eccentric training session in individuals with MS. Additionally, further investigate the association between systemic cytokine levels at rest and clinical measures of mobility and lower limb functional strength.
UNASSIGNED: Observational study.
UNASSIGNED: The first session included blood sampling for baseline cytokine measures. Subsequently, the participant completed a battery of clinical assessments related to mobility and lower limb strength, that is, the Timed-Up-and-Go Test, Five-Repetition-Sit-to-Stand-Test (5STS), Four-Square-Step-Test, and Two-Minute-Walk-Test. The second session included the eccentric exercise training session, followed by a second blood sampling to assess the acute cytokine response to the eccentric training bout. This session comprised 10 exercises concentrating on the strength of the trunk and lower extremities.
UNASSIGNED: Twenty-seven people with MS (pwMS), with a mean age of 40.1 years, participated in the study. No difference was demonstrated in the cytokine concentration values between baseline and immediately after the eccentric training session. The 5STS explained 30.3% of the variance associated with interferon-gamma, 14.8% with IL-4, and 13.8% with IL-10.
UNASSIGNED: An eccentric training bout does not impact cytokine concentration in the blood and, consequently, does not boost a pro-inflammatory response, thus, it can be performed on pwMS in a rehabilitation setting.
A strength-lengthening exercise session doesn’t affect inflammation markers in people with multiple sclerosis The article explores how a specific type of exercise, called eccentric muscle training, affects people with multiple sclerosis (MS). Eccentric muscle training involves exercises where the muscle lengthens under tension, like when you slowly lower a heavy object. This type of exercise is known for causing unique physical responses, including changes in certain proteins in the blood that help control the immune system and inflammation. The main goal of the study was to see if a session of eccentric muscle training would change the levels of these proteins, called cytokines, in the blood of people with MS immediately after exercise. The cytokines studied included IL-4, IL-6, IL-10, IL-17a, INF-γ, and TNF-α. These proteins are important because they help regulate inflammation and immune responses. The researchers also wanted to know if there was any connection between the levels of these proteins at rest and measures of mobility and leg strength. Twenty-seven people with MS took part in the study. Their average age was 40.1 years. In the first session, blood samples were taken to measure the baseline levels of these proteins, and various tests were conducted to assess mobility and leg strength. In the second session, participants completed an eccentric training session, and another blood sample was taken immediately after to see if there were any immediate changes in the protein levels. The results showed no significant differences in the protein levels before and after the exercise session. This suggests that a single session of eccentric muscle training does not cause an immediate inflammatory response in the blood. Therefore, this type of exercise can be safely included in rehabilitation programs for people with MS without the risk of causing harmful inflammation. Overall, the study supports the safety of eccentric muscle training for people with MS and provides valuable insights into its immediate effects on the immune system.