目的:研究Eales病患者眼底荧光血管造影(FA)的黄斑特征,光学相干断层扫描(OCT)和光学相干断层扫描血管造影(OCTA)。
方法:对Eales病的31只眼(23例)进行了横断面研究。基线参数,如最佳矫正视力(BCVA),裂隙灯生物显微镜(SLB),间接检眼镜,FA,进行谱域OCT{对SD-OCT进行定量(中央黄斑厚度[CMT])和定性分析}和OCTA.排除排除上述研究的任何介质不透明度。
结果:黄斑发现包括视网膜前膜,黄斑渗出,全厚度黄斑裂孔,次内部限制膜出血,黄斑囊样水肿,神经感觉脱离和视网膜增厚。我们的患者中有16例(51.6%)出现黄斑改变,如在所有方式上所见。SLB和间接检眼镜检查在50%的患者中错过了黄斑发现,在18.8%的患者中错过了FA。OCT和OCTA诊断所有黄斑发现。在比较FA黄斑受累患者的平均BCVA时,OCT和OCTA,与没有黄斑病变的患者相比,黄斑病变患者的BCVA较低(分别为p=0.000,0.01和0.001).因此,FA错过了许多黄斑受累明显的患者,因此视力较低。
结论:Eales病虽然在文献中描述为经典的周边视网膜疾病过程,也有黄斑受累。OCT和OCTA是评估这些患者黄斑受累的有用指南。后者在检测这种疾病的黄斑异常方面似乎优于FA。OCTA是非侵入性的,并且显示了深毛细血管丛的变化,任何其他方式都没有显示。
OBJECTIVE: To study the macular features in Eales disease patients observed with fundus fluorescein angiography (FA), optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA).
METHODS: A cross-sectional study was done on treatment naïve 31 eyes (23 patients) with Eales disease. Baseline parameters such as Best-corrected visual acuity (BCVA), slit-lamp bio microscopy (SLB), indirect ophthalmoscopy, FA, spectral-domain OCT {quantitative (central macular thickness [CMT]) and qualitative analysis on SD-OCT} and OCTA were performed. Any media opacity precluding the above investigations was excluded.
RESULTS: Macular findings comprised of- epiretinal membrane, macular exudation, full thickness macular hole, sub internal limiting membrane bleed, cystoid macular oedema, neurosensory detachment and retinal thickening. Sixteen (51.6%) of our patients had macular changes as seen on all modalities together. SLB and indirect ophthalmoscopy missed macular findings in 50% patients and FA in 18.8% patients. OCT and OCTA diagnosed all macular findings. On comparison of mean BCVA in patients with macular involvement on FA, OCT and OCTA, compared to those without macular involvement, patients with macular involvement had lower BCVA (p 0.000, 0.01 and 0.001 respectively). Thus, FA missed many patients who had significant macular involvement and hence less vision.
CONCLUSIONS: Eales disease though described in literature as classically being peripheral retina disease process, also has macular involvement. OCT and OCTA are useful guides to evaluation of macular involvement in these patients. The latter seems to be superior to FA in detecting macular abnormalities in this ailment. OCTA is non-invasive and shows deep capillary plexus changes which are not shown by any other modality.