Eag1(ether-à-go-go-1),电压依赖性钾通道家族的成员,主要在大脑中表达,胎盘中的水平很低,睾丸,和肾上腺,只在成肌细胞中短暂。最近,一些研究表明Eag1在各种肿瘤组织中选择性表达。Eag1在肿瘤增殖中起重要作用,恶性转化,入侵,转移,复发,和预后。因此,已成为肿瘤诊断的新分子靶点,预后评估,和肿瘤靶向治疗。这篇综述提供了关于理解Eag1结构的当前进展的信息,电生理特性,和在癌症中的作用。
Eag1 (ether-à-go-go-1), a member of the voltage-dependent potassium channel family, is expressed mainly in the brain, and at low levels in placenta, testis, and adrenal gland, and only transiently in myoblasts. Recently, several studies have suggested that
Eag1 is selectively expressed in various tumor tissues.
Eag1 plays important roles in tumor proliferation, malignant transformation, invasion, metastasis, recurrence, and prognosis. Therefore, it has become a new molecular target for tumor diagnosis, prognosis evaluation, and tumor-targeted therapy. This review provides information about the current progress in understanding
Eag1 structure, electrophysiological characteristics, and role in cancer.