癌症是可能影响一个人的最严重的疾病,也是导致死亡的主要原因。全球,乳腺癌仍然是女性癌症相关死亡的主要原因。近几十年来,使用替代药物和补充药物治疗疾病的普及有所增加;其中许多都来自植物。洋甘菊有治疗许多疾病的有益效果,这项工作的目的是研究洋甘菊如何保护成年雌性小鼠免受Ehrlich实体瘤(EST)引起的心脏损伤和毒性。40只雌性小鼠分为4组(对照组,洋甘菊,EST,EST+洋甘菊)。研究结果表明,EST引起了心脏功能和结构的显着改变。EST引起血清肌酸激酶(CK)显着升高,肌酸激酶MB(CK-MB),乳酸脱氢酶(LDH),碱性磷酸酶(ALP),和肌红蛋白(MB),钾,氯离子,胆固醇,甘油三酯,低密度脂蛋白(LDL),心脏组织损伤,细胞凋亡中P53和Caspase3的表达显著降低,而钠离子和高密度脂蛋白(HDL)的表达水平显著降低。用洋甘菊治疗EST改善了生化,组织病理学,和免疫组织化学改变。这表明洋甘菊可用作治疗和预防心脏毒性的佐剂。
Cancer is the most serious disorder that may affect a person and is also the leading cause of mortality. Worldwide, breast cancer continues to be the leading cause of cancer-related deaths in women. The popularity of treating diseases using alternative and complementary medicines has increased in recent decades; many of these are derived from plants. Chamomile has a beneficial effect in treating many diseases, there for the purpose of this work is to study how chamomile protect against cardiac damage and toxicity brought on by Ehrlich solid tumor (
EST) in adult female mice. 40 female mice were distributed in 4 groups (control, chamomile,
EST,
EST+chamomile). The research results indicated that
EST caused significant alterations in cardiac function and structure.
EST induced a significant elevation in serum creatine kinase (CK), creatine kinase MB (CK-MB), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), and myoglobin (MB), potassium, chloride ions, cholesterol, triglycerides, low-density lipoprotein (LDL), cardiac tissue damage, apoptotic P53 and Caspase 3 expressions while levels of sodium ions and high-density lipoprotein (HDL) were significantly decreased. Treatments of
EST with chamomile improved the biochemical, histopathological, and Immunohistochemical alterations. This suggests that chamomile may be useful as an adjuvant for the treatment and prevention of cardiac toxicity.