■评估无症状的早期屋尘螨致敏对7岁儿童过敏结局和肺功能的预测价值。
■台湾儿童过敏预测(PATCH)出生队列研究招募了出生时健康的新生儿。1.5-2岁,a翼状螨特异性免疫球蛋白E水平≥0.35kU/L定义为早期致敏。7岁时,变态反应的结果由儿科变态反应学家和肺科医师进行评估,测量呼出气一氧化氮和肺功能。
■1.5-2岁,28.0%的幼儿对D.pteronysinus敏感。其中,68.2%的患者当时无过敏症状。7岁时,早期致敏儿童患哮喘的风险较高(OR=13.4,95%CI,1.2~153.0;P=0.037),变应性鼻炎(OR=10.2,95%CI,2.1至49.6;P=0.004),和特应性皮炎(OR=38.5,95%CI,2.1至696.4;P=0.014)。值得注意的是,即使是无症状的早期D.pteronyssinus敏化的幼儿也有更高的哮喘概率(12.5%vs.1.7%,P=0.040),过敏性鼻炎(83.3%vs.43.1%,P=0.009),和特应性皮炎(20.8%vs.0.0%,7岁时P<0.001)。早期致敏的无症状幼儿在7岁时也有较高的呼出一氧化氮水平和较高的气道高反应性患病率。
■早期屋尘螨致敏的无症状幼儿患哮喘的风险更高,过敏性鼻炎,特应性皮炎,7岁时肺功能异常。
UNASSIGNED: To evaluate the predictive value of asymptomatic early house dust mite sensitization on allergic outcomes and pulmonary functions in 7-year olds.
UNASSIGNED: The Prediction of Allergies in Taiwanese Children (PATCH) birth cohort study recruited healthy newborns at birth. At age 1.5-2 years, a Dermatophagoides pteronyssinus-specific immunoglobulin E level ≥ 0.35 kU/L was defined as early sensitization. At age 7 years, allergic outcomes were evaluated by pediatric allergists and pulmonologists, and fractional exhaled nitric oxide and pulmonary functions were measured.
UNASSIGNED: At age 1.5-2 years, 28.0% of toddlers were sensitized to D. pteronyssinus. Among them, 68.2% had no allergic symptoms at that time. At age 7 years, the children with early sensitization had higher risks of asthma (OR = 13.4, 95% CI, 1.2 to 153.0; P = 0.037), allergic rhinitis (OR = 10.2, 95% CI, 2.1 to 49.6; P = 0.004), and atopic dermatitis (OR = 38.5, 95% CI, 2.1 to 696.4; P = 0.014). Notably, even the asymptomatic toddlers with early D. pteronyssinus sensitization had higher probabilities of asthma (12.5% vs. 1.7%, P = 0.040), allergic rhinitis (83.3% vs. 43.1%, P = 0.009), and atopic dermatitis (20.8% vs. 0.0%, P < 0.001) at age 7 years. The asymptomatic toddlers with early sensitization also had higher exhaled nitric oxide levels and higher prevalence of airway hyperresponsiveness at age 7 years.
UNASSIGNED: Asymptomatic toddlers with early house dust mite sensitization have higher risks of developing asthma, allergic rhinitis, atopic dermatitis, and abnormal lung functions at age 7 years.