■化疗引起的周围神经病变(CIPN)是几种用于对抗癌症的药物的常见副作用。因此,研究人员寻求更好的治疗和预防CIPN,如电针(EA)。一些试验显示EA恶化或延长CIPN疼痛,并建议不要对此进行进一步研究。这篇叙述性综述探讨了EA在预防或治疗CIPN、比较积极和消极的结果。
■PubMed,ScienceDirect,谷歌学者被搜索电针,CIPN,和周围神经病变。采用滚雪球法寻找系统评价和系统评价中的研究。
■发现了使用EA预防或治疗CIPN的七项英语试验。在3项预防研究中,1有显著的好处,1有适度的好处,在随访时,EA组疼痛加重,与假对照相比。在4项治疗研究中,2有显著的好处,1与3个对照没有差异,1例具有假对照优于verumEA。
■大多数研究都受到小样本量的限制,一些研究使用的EA方案和治疗剂量(频率和总次数)可能是次优的.研究的数量和质量不足以就有效性和安全性得出确切的结论。更多的研究必须测试最佳的EA方案和治疗剂量。说EA不推荐用于CIPN预防或治疗是不合适的,因为没有有力的证据证明这一点。一般来说,研究发现了好处,没有危害。
UNASSIGNED: Chemotherapy-induced peripheral neuropathy (CIPN) is a common side-effect of several drugs used to combat cancer. Thus, researchers have sought better treatments for and prevention of CIPN, such as electroacupuncture (
EA). Some trials show
EA worsens or prolongs CIPN pain and recommend against further studies on this. This narrative review explores EA for preventing or treating CIPN, comparing positive and negative outcomes.
UNASSIGNED: PubMed, ScienceDirect, and Google Scholar were searched for electroacupuncture, CIPN, and peripheral neuropathy. A snowballing method was used to find systematic reviews and studies in systematic reviews.
UNASSIGNED: Seven English-language trials were found on using
EA for preventing or treating CIPN. In 3 prevention studies, 1 had significant benefits, 1 had modest benefits, and 1 had worse pain in an
EA group at follow-up, compared to sham controls. In 4 treatment studies, 2 had significant benefits, 1 had no difference from 3 controls, and 1 had sham control was superior to verum EA.
UNASSIGNED: Most of the studies were limited by small sample sizes, and some studies used EA protocols and treatment doses (frequency and total number of sessions) that were potentially suboptimal. The quantity and quality of the studies are insufficient to draw firm conclusions on effectiveness and safety. More studies must test optimal
EA protocols and treatment dosages. It is inappropriate to say that EA is not recommended for CIPN prevention or treatment, because there is no robust evidence to justify this. Generally, research has found benefits and no harms.