未经评估:探讨未治疗精神病(DUP)的持续时间与长期临床结果之间的关系,慢性精神分裂症(SCZ)患者的认知和社会功能。
未经评估:本研究共纳入248名慢性SCZ患者,其中短DUP组156个,长DUP组92个。阳性和阴性症状量表(PANSS),简短阴性症状量表(BNSS),使用全球功能评估(GAF)量表和可重复的神经心理状态评估电池(RBANS)对所有受试者进行评估.
UNASSIGNED:长DUP受试者的阴性症状评分(PANSS和BNSS)明显高于短DUP受试者。短DUP组的视觉跨度和语音功能评分明显高于对照组,表明认知功能随时间下降。在社会功能方面,短DUP组得分较高,具有统计学上的显著差异。同时,我们发现DUP的长度与PANSS的阴性症状评分呈正相关,与视觉跨度得分呈负相关,和GAF分数。
UNASSIGNED:这项研究表明,在长期慢性SCZ中,DUP仍然与阴性症状和认知有显著关联。
UNASSIGNED: To explore the relationship between the Duration of Untreated Psychosis (DUP) and long-term clinical outcome, cognitive and social function in patients with chronic schizophrenia (SCZ).
UNASSIGNED: A total of 248 subjects with chronic SCZ were enrolled in this study, including 156 in the short DUP group and 92 in the long DUP group. The Positive and Negative Symptoms Scale (PANSS), the Brief Negative Symptoms Scale (BNSS), the Global Assessment of Functioning (GAF) scale and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) were used to assess all of the subjects.
UNASSIGNED: The negative symptom scores (the PANSS and BNSS) of subjects with long DUP were significantly higher than that in subjects with short DUP. The scores of visual span and speech function in the short DUP group were significantly higher, indicative of decreasing cognitive function with time. In terms of social function, the short DUP group scored higher, with a statistically significant difference. Meanwhile, we found that the length of DUP was positively correlated with the negative symptom score of the PANSS, negatively correlated with visual span scores, and GAF scores.
UNASSIGNED: This study demonstrated that the DUP remained a significant association with negative symptom and cognition in long period of chronic SCZ.