成釉细胞瘤是罕见的组织学良性，由口腔外胚层引起的局部侵袭性肿瘤，偶尔会达到巨大的大小。如今，随着常规牙科实践中全景射线照相的出现，巨大的成釉细胞瘤很少见。此外，颗粒细胞变异是成釉细胞瘤的一种少见的组织学亚型，其中肿瘤滤泡中的中央星状网状细胞被颗粒细胞取代。尽管颗粒细胞成釉细胞瘤（GCA）被认为是一种具有高复发率的破坏性肿瘤，颗粒细胞在预测其生物学行为中的意义是有争议的。然而,我们介绍了一个罕见的巨大GCA病例，其组织形态学异常，显示广泛的颅面受累和硬脑膜延伸，治疗后预后良好。
Ameloblastomas are rare histologically benign, locally aggressive tumors arising from the oral ectoderm that occasionally reach a gigantic size. Giant ameloblastomas are a rarity these days with the advent of panoramic radiography in routine dental practice. Furthermore, the granular cell variant is an uncommon histological subtype of ameloblastoma where the central stellate reticulum like cells in tumor follicles is replaced by granular cells. Although granular cell ameloblastoma (GCA) is considered to be a destructive tumor with a high recurrence rate, the significance of granular cells in predicting its biologic behavior is debatable. However, we present a rare case of giant GCA of remarkable histomorphology showing extensive craniofacial involvement and dural extension that rendered a good prognosis following treatment.
