应用多序列MR影像组学特征,分析放疗前后脑白质的变化,建立影像组学特征变化与辐射剂量的关系。
这项研究选择了88例接受过RT的脑肿瘤患者,和MR图像(T1,T1+C,T2FLAIR,T2,DWI,和ASL)在RT之前和之后获得。在0-5Gy的剂量梯度下,将脑白质描绘为ROI,5-10Gy,10-15Gy,15-20Gy,20-30Gy,30-40Gy,和40-50Gy。提取每个ROI的影像组学特征,比较不同剂量梯度下不同序列放疗前后影像组学特征的变化。
在每个剂量梯度,不同MR序列的统计学显著特征主要集中在三个剂量梯度上,5-10Gy,20-30Gy,和30-40Gy.T1+C序列在20-30Gy剂量梯度下保持大多数特征(66)。在20-30Gy的剂量梯度下有20个一般特征,30-40Gy,和40-50Gy,随着剂量增加,特征的变化先减少后增加。剂量梯度为5-10Gy和10-15Gy,只有T1和T2FLAIR具有一般功能,T1的变化率分别为-24.57%和-29.32%,T2FLAIR的变化率分别为-3.08%和-10.87%,分别。随着剂量的增加,变化呈上升趋势。对于在相同剂量梯度下分析的不同MR序列,所有序列都有5-10Gy,20-30Gy和30-40Gy具有一般特征,除了T2FLAIR序列,集中在FirstOrder类别功能中,T1和T1+C的特征变化比其他序列更显著。
MR影像组学特征揭示了RT前后脑白质的微观变化,尽管每个特征没有恒定的剂量效应关系。不同序列中影像组学特征的变化可以揭示脑白质对不同剂量的辐射反应。
To analyse the changes in brain white matter before and after radiotherapy (RT) by applying multisequence MR radiomics features and to establish a relationship between the changes in radiomics features and radiation dose.
Eighty-eight patients with brain tumours who had undergone RT were selected in this study, and MR images (T1, T1+C, T2FLAIR, T2, DWI, and ASL) before and after RT were obtained. The brain white matter was delineated as an ROI under dose gradients of 0-5 Gy, 5-10 Gy, 10-15 Gy, 15-20 Gy, 20-30 Gy, 30-40 Gy, and 40-50 Gy. The radiomics features of each ROI were extracted, and the changes in radiomics features before and after RT for different sequences under different dose gradients were compared.
At each dose gradient, statistically significant features of different MR sequences were mainly concentrated in three dose gradients, 5-10 Gy, 20-30 Gy, and 30-40 Gy. The T1+C sequence held the most features (66) under the 20-30 Gy dose gradient. There were 20 general features at dose gradients of 20-30 Gy, 30-40 Gy, and 40-50 Gy, and the changes in features first decreased and then increased following dose escalation. With dose gradients of 5-10 Gy and 10-15 Gy, only T1 and T2FLAIR had general features, and the rates of change were - 24.57% and - 29.32% for T1 and - 3.08% and - 10.87% for T2FLAIR, respectively. The changes showed an upward trend with increasing doses. For different MR sequences that were analysed under the same dose gradient, all sequences with 5-10 Gy, 20-30 Gy and 30-40 Gy had general features, except the T2FLAIR sequence, which was concentrated in the FirstOrder category feature, and the changes in features of T1 and T1+C were more significant than those of the other sequences.
MR radiomics features revealed microscopic changes in brain white matter before and after RT, although there was no constant dose-effect relationship for each feature. The changes in radiomics features in different sequences could reveal the radiation response of brain white matter to different doses.