流入道的发育无疑是四腔心脏形成中最复杂的重塑事件之一。它涉及创建两个独立的心房腔,心房/房室间隔复合体的形成,腔静脉和冠状窦并入右心房,以及导致肺静脉回流到左心房的重塑事件。在这些过程中,房室间充质复合物,由主要的房室(AV)垫组成,主房间隔(pAS)上的间充质帽,和背侧间充质突起(DMP),起着至关重要的作用。
The development of the inflow tract is undoubtedly one of the most complex remodeling events in the formation of the four-chambered heart. It involves the creation of two separate atrial chambers, the formation of an atrial/atrioventricular (AV) septal complex, the incorporation of the caval veins and coronary sinus into the right atrium, and the remodeling events that result in pulmonary venous return draining into the left atrium. In these processes, the atrioventricular mesenchymal complex, consisting of the major atrioventricular (AV) cushions, the mesenchymal cap on the primary atrial septum (pAS), and the dorsal mesenchymal protrusion (DMP), plays a crucial role.